CD4+ T-cell memory

Generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza

Susan L. Swain, Javed N. Agrewala, Deborah M Brown, Dawn M. Jelley-Gibbs, Susanne Golech, Gail Huston, Stephen C. Jones, Cris Kamperschroer, Won Ha Lee, K. Kai McKinstry, Eulogia Román, Tara Strutt, Nan Ping Weng

Research output: Contribution to journalReview article

139 Citations (Scopus)

Abstract

We have outlined the carefully orchestrated process of CD4+ T-cell differentiation from naïve to effector and from effector to memory cells with a focus on how these processes can be studied in vivo in responses to pathogen infection. We emphasize that the regulatory factors that determine the quality and quantity of the effector and memory cells generated include (i) the antigen dose during the initial T-cell interaction with antigen-presenting cells; (ii) the dose and duration of repeated interactions; and (iii) the milieu of inflammatory and growth cytokines that responding CD4+ T cells encounter. We suggest that heterogeneity in these regulatory factors leads to the generation of a spectrum of effectors with different functional attributes. Furthermore, we suggest that it is the presence of effectors at different stages along a pathway of progressive linear differentiation that leads to a related spectrum of memory cells. Our studies particularly highlight the multifaceted roles of CD4+ effector and memory T cells in protective responses to influenza infection and support the concept that efficient priming of CD4 + T cells that react to shared influenza proteins could contribute greatly to vaccine strategies for influenza.

Original languageEnglish (US)
Pages (from-to)8-22
Number of pages15
JournalImmunological Reviews
Volume211
DOIs
StatePublished - Jun 1 2006

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Human Influenza
Immunity
T-Lymphocytes
Influenza Vaccines
Antigen-Presenting Cells
Infection
Cell Communication
Cell Differentiation
Cytokines
Antigens
Growth
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

CD4+ T-cell memory : Generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza. / Swain, Susan L.; Agrewala, Javed N.; Brown, Deborah M; Jelley-Gibbs, Dawn M.; Golech, Susanne; Huston, Gail; Jones, Stephen C.; Kamperschroer, Cris; Lee, Won Ha; McKinstry, K. Kai; Román, Eulogia; Strutt, Tara; Weng, Nan Ping.

In: Immunological Reviews, Vol. 211, 01.06.2006, p. 8-22.

Research output: Contribution to journalReview article

Swain, SL, Agrewala, JN, Brown, DM, Jelley-Gibbs, DM, Golech, S, Huston, G, Jones, SC, Kamperschroer, C, Lee, WH, McKinstry, KK, Román, E, Strutt, T & Weng, NP 2006, 'CD4+ T-cell memory: Generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza', Immunological Reviews, vol. 211, pp. 8-22. https://doi.org/10.1111/j.0105-2896.2006.00388.x
Swain, Susan L. ; Agrewala, Javed N. ; Brown, Deborah M ; Jelley-Gibbs, Dawn M. ; Golech, Susanne ; Huston, Gail ; Jones, Stephen C. ; Kamperschroer, Cris ; Lee, Won Ha ; McKinstry, K. Kai ; Román, Eulogia ; Strutt, Tara ; Weng, Nan Ping. / CD4+ T-cell memory : Generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza. In: Immunological Reviews. 2006 ; Vol. 211. pp. 8-22.
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