CD43 expression is associated with inferior survival in the non-germinal centre B-cell subgroup of diffuse large B-cell lymphoma

Zdravko Mitrovic, Javeed Iqbal, Kai Fu, Lynette M Smith, Martin Bast, Timothy Charles Greiner, Patricia Aoun, James Olen Armitage, Julie Marie Vose, Dennis D. Weisenburger, Wing C. Chan

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We evaluated the prognostic significance of CD43 (SPN), a membrane glycoprotein, in 140 patients with diffuse large B-cell lymphoma (DLBCL) by tissue microarray (TMA) immunostaining, and gene expression profiling (GEP) in 43 patients. CD43 protein was expressed in 19% of the cases and was strongly related to the non-germinal centre B-cell (non-GCB) subgroup by both TMA and GEP. Patients with CD43(+) DLBCL had an inferior 3-year overall survival (OS) compared to those with CD43(-) DLBCL (50% vs. 76%, P = 0·01). Within the non-GCB subgroup, patients with CD43(+) DLBCL had a particularly poor 3-year OS (32% vs. 71%, P < 0·001). Gene set enrichment analysis within the activated B-cell subgroup revealed significant enrichment in the stromal-1 signature in CD43(-) cases. We conclude that CD43 is an adverse prognostic marker in DLBCL, and is preferentially expressed in the non-GCB subgroup. The dismal outcome of CD43(+) cases in the non-GCB subgroup may be explained, at least in part, by a less favourable microenvironment.

Original languageEnglish (US)
Pages (from-to)87-92
Number of pages6
JournalBritish Journal of Haematology
Volume162
Issue number1
DOIs
StatePublished - Jul 1 2013

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Lymphoma, Large B-Cell, Diffuse
B-Lymphocytes
Survival
Gene Expression Profiling
Membrane Glycoproteins
Genes
Proteins

Keywords

  • CD43 (SPN)
  • Cell of origin
  • Diffuse large B-cell lymphoma
  • Microenvironment
  • Prognostic marker

ASJC Scopus subject areas

  • Hematology

Cite this

CD43 expression is associated with inferior survival in the non-germinal centre B-cell subgroup of diffuse large B-cell lymphoma. / Mitrovic, Zdravko; Iqbal, Javeed; Fu, Kai; Smith, Lynette M; Bast, Martin; Greiner, Timothy Charles; Aoun, Patricia; Armitage, James Olen; Vose, Julie Marie; Weisenburger, Dennis D.; Chan, Wing C.

In: British Journal of Haematology, Vol. 162, No. 1, 01.07.2013, p. 87-92.

Research output: Contribution to journalArticle

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AU - Iqbal, Javeed

AU - Fu, Kai

AU - Smith, Lynette M

AU - Bast, Martin

AU - Greiner, Timothy Charles

AU - Aoun, Patricia

AU - Armitage, James Olen

AU - Vose, Julie Marie

AU - Weisenburger, Dennis D.

AU - Chan, Wing C.

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