CD4 T cell responses to influenza infection

Deborah M. Brown, Eulogia Román, Susan L. Swain

Research output: Contribution to journalReview article

117 Citations (Scopus)

Abstract

Immune responses to viral infections involve a complex orchestration between innate signals and adaptive responses of specific T and B cells. Anti-viral CD4 cells can direct CD8 responses by secreting a Type 1 panel of cytokines including IFN-γ, IL-2 and TNF-α and can drive B cell production of IgG2a to neutralize infective viral particles. This review will focus specifically on the role of CD4 cells in the immune response to influenza, an acute, localized respiratory viral infection. We suggest that CD4 cells act as direct effectors in protection against influenza, may contribute to immunopathology and generate functionally distinct memory subsets.

Original languageEnglish (US)
Pages (from-to)171-177
Number of pages7
JournalSeminars in Immunology
Volume16
Issue number3
DOIs
StatePublished - Jun 1 2004

Fingerprint

Human Influenza
Virus Diseases
T-Lymphocytes
B-Lymphocytes
Infection
Respiratory Tract Infections
Virion
Interleukin-2
Cytokines
Drive

Keywords

  • A/Puerto Rico/8/34
  • BAL
  • CD4 T cells
  • CFSE
  • Cytotoxicity
  • IFN
  • IFN-γ
  • Influenza
  • LN
  • Memory T cells
  • PR8
  • bronchoalveolar lavage
  • carboxyfluorescein diacetate succinimydyl ester
  • interferon
  • lymph node

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

CD4 T cell responses to influenza infection. / Brown, Deborah M.; Román, Eulogia; Swain, Susan L.

In: Seminars in Immunology, Vol. 16, No. 3, 01.06.2004, p. 171-177.

Research output: Contribution to journalReview article

Brown, Deborah M. ; Román, Eulogia ; Swain, Susan L. / CD4 T cell responses to influenza infection. In: Seminars in Immunology. 2004 ; Vol. 16, No. 3. pp. 171-177.
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