CD28- CD8+ T cells are significantly reduced and correlate with disease duration in juveniles with type 1 diabetes

Danielle N. Yarde, Kristina Lorenzo-Arteaga, Kevin P. Corley, Monina Cabrera, Nora E Sarvetnick

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Type 1 diabetes (T1D) is a chronic disease caused by autoimmune destruction of insulin-producing pancreatic β-cells. T1D is typically diagnosed in children, but information regarding immune cell subsets in juveniles with T1D is scarce. Therefore, we studied various lymphocytic populations found in the peripheral blood of juveniles with T1D compared to age-matched controls (ages 2-17). One population of interest is the CD28- CD8+ T cell subset, which are late-differentiated cells also described as suppressors. These cells are altered in a number of disease states and have been shown to be reduced in adults with T1D. We found that the proportion of CD28- cells within the CD8+ T cell population is significantly reduced in juvenile type 1 diabetics. Furthermore, this reduction is not correlated with age in T1D juveniles, although a significant negative correlation between proportion CD28- CD8+ T cells and age was observed in the healthy controls. Finally, correlation analysis revealed a significant and negative correlation between the proportion of CD28- CD8+ T cells and T1D disease duration. These findings show that the CD28- CD8+ T cell population is perturbed following onset of disease and may prove to be a valuable marker for monitoring the progression of T1D.

Original languageEnglish (US)
Pages (from-to)1069-1074
Number of pages6
JournalHuman Immunology
Volume75
Issue number10
DOIs
StatePublished - Oct 1 2014

Fingerprint

Type 1 Diabetes Mellitus
T-Lymphocytes
Population
T-Lymphocyte Subsets
Chronic Disease
Insulin

Keywords

  • CD28 CD8 T cells
  • Juvenile type 1 diabetes
  • T suppressor cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

CD28- CD8+ T cells are significantly reduced and correlate with disease duration in juveniles with type 1 diabetes. / Yarde, Danielle N.; Lorenzo-Arteaga, Kristina; Corley, Kevin P.; Cabrera, Monina; Sarvetnick, Nora E.

In: Human Immunology, Vol. 75, No. 10, 01.10.2014, p. 1069-1074.

Research output: Contribution to journalArticle

Yarde, Danielle N. ; Lorenzo-Arteaga, Kristina ; Corley, Kevin P. ; Cabrera, Monina ; Sarvetnick, Nora E. / CD28- CD8+ T cells are significantly reduced and correlate with disease duration in juveniles with type 1 diabetes. In: Human Immunology. 2014 ; Vol. 75, No. 10. pp. 1069-1074.
@article{390af239299d4999a50888d2df31208e,
title = "CD28- CD8+ T cells are significantly reduced and correlate with disease duration in juveniles with type 1 diabetes",
abstract = "Type 1 diabetes (T1D) is a chronic disease caused by autoimmune destruction of insulin-producing pancreatic β-cells. T1D is typically diagnosed in children, but information regarding immune cell subsets in juveniles with T1D is scarce. Therefore, we studied various lymphocytic populations found in the peripheral blood of juveniles with T1D compared to age-matched controls (ages 2-17). One population of interest is the CD28- CD8+ T cell subset, which are late-differentiated cells also described as suppressors. These cells are altered in a number of disease states and have been shown to be reduced in adults with T1D. We found that the proportion of CD28- cells within the CD8+ T cell population is significantly reduced in juvenile type 1 diabetics. Furthermore, this reduction is not correlated with age in T1D juveniles, although a significant negative correlation between proportion CD28- CD8+ T cells and age was observed in the healthy controls. Finally, correlation analysis revealed a significant and negative correlation between the proportion of CD28- CD8+ T cells and T1D disease duration. These findings show that the CD28- CD8+ T cell population is perturbed following onset of disease and may prove to be a valuable marker for monitoring the progression of T1D.",
keywords = "CD28 CD8 T cells, Juvenile type 1 diabetes, T suppressor cells",
author = "Yarde, {Danielle N.} and Kristina Lorenzo-Arteaga and Corley, {Kevin P.} and Monina Cabrera and Sarvetnick, {Nora E}",
year = "2014",
month = "10",
day = "1",
doi = "10.1016/j.humimm.2014.09.007",
language = "English (US)",
volume = "75",
pages = "1069--1074",
journal = "Human Immunology",
issn = "0198-8859",
publisher = "Elsevier Inc.",
number = "10",

}

TY - JOUR

T1 - CD28- CD8+ T cells are significantly reduced and correlate with disease duration in juveniles with type 1 diabetes

AU - Yarde, Danielle N.

AU - Lorenzo-Arteaga, Kristina

AU - Corley, Kevin P.

AU - Cabrera, Monina

AU - Sarvetnick, Nora E

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Type 1 diabetes (T1D) is a chronic disease caused by autoimmune destruction of insulin-producing pancreatic β-cells. T1D is typically diagnosed in children, but information regarding immune cell subsets in juveniles with T1D is scarce. Therefore, we studied various lymphocytic populations found in the peripheral blood of juveniles with T1D compared to age-matched controls (ages 2-17). One population of interest is the CD28- CD8+ T cell subset, which are late-differentiated cells also described as suppressors. These cells are altered in a number of disease states and have been shown to be reduced in adults with T1D. We found that the proportion of CD28- cells within the CD8+ T cell population is significantly reduced in juvenile type 1 diabetics. Furthermore, this reduction is not correlated with age in T1D juveniles, although a significant negative correlation between proportion CD28- CD8+ T cells and age was observed in the healthy controls. Finally, correlation analysis revealed a significant and negative correlation between the proportion of CD28- CD8+ T cells and T1D disease duration. These findings show that the CD28- CD8+ T cell population is perturbed following onset of disease and may prove to be a valuable marker for monitoring the progression of T1D.

AB - Type 1 diabetes (T1D) is a chronic disease caused by autoimmune destruction of insulin-producing pancreatic β-cells. T1D is typically diagnosed in children, but information regarding immune cell subsets in juveniles with T1D is scarce. Therefore, we studied various lymphocytic populations found in the peripheral blood of juveniles with T1D compared to age-matched controls (ages 2-17). One population of interest is the CD28- CD8+ T cell subset, which are late-differentiated cells also described as suppressors. These cells are altered in a number of disease states and have been shown to be reduced in adults with T1D. We found that the proportion of CD28- cells within the CD8+ T cell population is significantly reduced in juvenile type 1 diabetics. Furthermore, this reduction is not correlated with age in T1D juveniles, although a significant negative correlation between proportion CD28- CD8+ T cells and age was observed in the healthy controls. Finally, correlation analysis revealed a significant and negative correlation between the proportion of CD28- CD8+ T cells and T1D disease duration. These findings show that the CD28- CD8+ T cell population is perturbed following onset of disease and may prove to be a valuable marker for monitoring the progression of T1D.

KW - CD28 CD8 T cells

KW - Juvenile type 1 diabetes

KW - T suppressor cells

UR - http://www.scopus.com/inward/record.url?scp=84907964868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907964868&partnerID=8YFLogxK

U2 - 10.1016/j.humimm.2014.09.007

DO - 10.1016/j.humimm.2014.09.007

M3 - Article

C2 - 25241914

AN - SCOPUS:84907964868

VL - 75

SP - 1069

EP - 1074

JO - Human Immunology

JF - Human Immunology

SN - 0198-8859

IS - 10

ER -