CD200: Association with cancer stem cell features and response to chemoradiation in head and neck squamous cell carcinoma

Yuh Seog Jung, Paola D. Vermeer, Daniel W. Vermeer, Sang Jin Lee, Ah Ra Goh, Hyun Joo Ahn, John H. Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background. The purpose of this study was to characterize the expression of CD200, a membrane protein that functions in immune evasion, to examine its correlations with cancer stem cell (CSC)-like features and analyze its response to chemotherapy and radiation in human papillomavirus (HPV)-positive (+) and negative (-) head and neck squamous cell carcinomas (HNSCCs). Methods. CD200 expression was analyzed in several HNSCC cell lines. CD200 was overexpressed in HPV(+) murine tonsil epithelial cells, its effects on Shh and Bmi-1 were examined in vitro, and tumor growth and response to chemoradiation were analyzed in vitro and in vivo. Results. CD200 was diversely expressed and consistently associated with expression of Bmi-1 and Shh. Overexpression of CD200 induced Bmi-1 and Shh. Tumors grew similarly between C57BL/6 and Rag1-/- C57BL/6 mice. CD200 expression enhanced the resistance to chemoradiation only in vivo. Conclusion. CD200 was related to CSC features and modulates response to chemoradiation in vivo. Attenuating this might be a potential therapeutic strategy.

Original languageEnglish (US)
Pages (from-to)327-335
Number of pages9
JournalHead and Neck
Volume37
Issue number3
DOIs
StatePublished - Mar 1 2015

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Neoplastic Stem Cells
Immune Evasion
Palatine Tonsil
Inbred C57BL Mouse
Neoplasms
Membrane Proteins
Epithelial Cells
Radiation
Drug Therapy
Cell Line
Growth
In Vitro Techniques
Carcinoma, squamous cell of head and neck
Therapeutics

Keywords

  • CD200
  • Human papillomavirus
  • Immune tolerance
  • Neoplastic stem cells
  • Oropharyngeal cancer

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

CD200 : Association with cancer stem cell features and response to chemoradiation in head and neck squamous cell carcinoma. / Jung, Yuh Seog; Vermeer, Paola D.; Vermeer, Daniel W.; Lee, Sang Jin; Goh, Ah Ra; Ahn, Hyun Joo; Lee, John H.

In: Head and Neck, Vol. 37, No. 3, 01.03.2015, p. 327-335.

Research output: Contribution to journalArticle

Jung, Yuh Seog ; Vermeer, Paola D. ; Vermeer, Daniel W. ; Lee, Sang Jin ; Goh, Ah Ra ; Ahn, Hyun Joo ; Lee, John H. / CD200 : Association with cancer stem cell features and response to chemoradiation in head and neck squamous cell carcinoma. In: Head and Neck. 2015 ; Vol. 37, No. 3. pp. 327-335.
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