CD 4+ T cells in the pathobiology of neurodegenerative disorders

Xiuyan Huang, Ashley D. Reynolds, R Lee Mosley, Howard Eliot Gendelman

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

CD4+ T cells orchestrate innate and adaptive immunity. In the central nervous system they modulate immune responses including cell trafficking and glial neuroregulatory functions through an array of soluble molecules cell-cell interactions affecting tissue homeostasis. During disease their roles evolve to an auto-aggressive or, alternatively, protective phenotype. How such a balance is struck in the setting of neurodegenerative disorders may reflect a dichotomy between regulatory T cell, anti-inflammatory and neuroprotective activities versus effector T cell inflammation and neurodegeneration. Interestingly, such roles may show commonalities amongst neurodegenerative diseases. Herein we focus on strategies to modulate such CD4+ T cell responses for therapeutic gain.

Original languageEnglish (US)
Pages (from-to)3-15
Number of pages13
JournalJournal of Neuroimmunology
Volume211
Issue number1-2
DOIs
StatePublished - Jun 25 2009

Fingerprint

Neurodegenerative Diseases
T-Lymphocytes
Adaptive Immunity
Regulatory T-Lymphocytes
Innate Immunity
Cell Communication
Neuroglia
Homeostasis
Anti-Inflammatory Agents
Central Nervous System
Inflammation
Phenotype
Therapeutics

Keywords

  • AD, Alzheimer's disease
  • BBB, blood brain barrier.
  • HAND, HIV-1 associated neurocognitive disorders
  • MP, mononuclear phagocytes
  • PD, Parkinson's disease
  • Teff, effector T cells
  • Treg, regulatory T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

CD 4+ T cells in the pathobiology of neurodegenerative disorders. / Huang, Xiuyan; Reynolds, Ashley D.; Mosley, R Lee; Gendelman, Howard Eliot.

In: Journal of Neuroimmunology, Vol. 211, No. 1-2, 25.06.2009, p. 3-15.

Research output: Contribution to journalReview article

@article{61c9982c664747c19780a17ff21f325c,
title = "CD 4+ T cells in the pathobiology of neurodegenerative disorders",
abstract = "CD4+ T cells orchestrate innate and adaptive immunity. In the central nervous system they modulate immune responses including cell trafficking and glial neuroregulatory functions through an array of soluble molecules cell-cell interactions affecting tissue homeostasis. During disease their roles evolve to an auto-aggressive or, alternatively, protective phenotype. How such a balance is struck in the setting of neurodegenerative disorders may reflect a dichotomy between regulatory T cell, anti-inflammatory and neuroprotective activities versus effector T cell inflammation and neurodegeneration. Interestingly, such roles may show commonalities amongst neurodegenerative diseases. Herein we focus on strategies to modulate such CD4+ T cell responses for therapeutic gain.",
keywords = "AD, Alzheimer's disease, BBB, blood brain barrier., HAND, HIV-1 associated neurocognitive disorders, MP, mononuclear phagocytes, PD, Parkinson's disease, Teff, effector T cells, Treg, regulatory T cells",
author = "Xiuyan Huang and Reynolds, {Ashley D.} and Mosley, {R Lee} and Gendelman, {Howard Eliot}",
year = "2009",
month = "6",
day = "25",
doi = "10.1016/j.jneuroim.2009.04.006",
language = "English (US)",
volume = "211",
pages = "3--15",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - CD 4+ T cells in the pathobiology of neurodegenerative disorders

AU - Huang, Xiuyan

AU - Reynolds, Ashley D.

AU - Mosley, R Lee

AU - Gendelman, Howard Eliot

PY - 2009/6/25

Y1 - 2009/6/25

N2 - CD4+ T cells orchestrate innate and adaptive immunity. In the central nervous system they modulate immune responses including cell trafficking and glial neuroregulatory functions through an array of soluble molecules cell-cell interactions affecting tissue homeostasis. During disease their roles evolve to an auto-aggressive or, alternatively, protective phenotype. How such a balance is struck in the setting of neurodegenerative disorders may reflect a dichotomy between regulatory T cell, anti-inflammatory and neuroprotective activities versus effector T cell inflammation and neurodegeneration. Interestingly, such roles may show commonalities amongst neurodegenerative diseases. Herein we focus on strategies to modulate such CD4+ T cell responses for therapeutic gain.

AB - CD4+ T cells orchestrate innate and adaptive immunity. In the central nervous system they modulate immune responses including cell trafficking and glial neuroregulatory functions through an array of soluble molecules cell-cell interactions affecting tissue homeostasis. During disease their roles evolve to an auto-aggressive or, alternatively, protective phenotype. How such a balance is struck in the setting of neurodegenerative disorders may reflect a dichotomy between regulatory T cell, anti-inflammatory and neuroprotective activities versus effector T cell inflammation and neurodegeneration. Interestingly, such roles may show commonalities amongst neurodegenerative diseases. Herein we focus on strategies to modulate such CD4+ T cell responses for therapeutic gain.

KW - AD, Alzheimer's disease

KW - BBB, blood brain barrier.

KW - HAND, HIV-1 associated neurocognitive disorders

KW - MP, mononuclear phagocytes

KW - PD, Parkinson's disease

KW - Teff, effector T cells

KW - Treg, regulatory T cells

UR - http://www.scopus.com/inward/record.url?scp=67349106416&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349106416&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2009.04.006

DO - 10.1016/j.jneuroim.2009.04.006

M3 - Review article

VL - 211

SP - 3

EP - 15

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -