CCL2 affects β-amyloidosis and progressive neurocognitive dysfunction in a mouse model of Alzheimer's disease

Tomomi Kiyota, Howard Eliot Gendelman, Robert A. Weir, E. Elizabeth Higgins, Gang Zhang, Mohit Jain

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Neuroinflammation affects the pathobiology of Alzheimer's disease (AD). Notably, β-amyloid (Aβ) deposition induces microglial activation and the subsequent production of proinflammatory neurotoxic factors. In maintaining brain homeostasis, microglial plasticity also enables phenotypic transition between toxic and trophic activation states. One important control for such cell activation is through the CC-chemokine ligand 2 (CCL2) and its receptor, the CC-chemokine receptor 2. Both affect microglia and peripheral macrophage immune responses and for the latter, cell ingress across the blood-brain barrier. However, how CCL2-CC-chemokine receptor 2 signaling contributes to AD pathogenesis is not well understood. To this end, we now report that CCL2 deficiency influences behavioral abnormalities and disease progression in Aβ precursor protein/presenilin-1 double-transgenic mice. Here, increased cortical and hippocampal Aβ deposition is coincident with the formulation of Aβ oligomers. Deficits in peripheral Aβ clearance and in scavenger, neuroprogenitor, and microglial cell functions are linked to deficient Aβ uptake. All serve to accelerate memory dysfunction. Taken together, these data support a role of CCL2 in innate immune functions relevant to AD pathogenesis.

Original languageEnglish (US)
Pages (from-to)1060-1068
Number of pages9
JournalNeurobiology of Aging
Volume34
Issue number4
DOIs
StatePublished - Apr 1 2013

Fingerprint

CC Chemokines
Amyloidosis
Alzheimer Disease
CCR2 Receptors
Ligands
Presenilin-1
Protein Precursors
Poisons
Microglia
Blood-Brain Barrier
Amyloid
Transgenic Mice
Disease Progression
Homeostasis
Macrophages
Brain

Keywords

  • Chemokine
  • Memory function
  • Microglia
  • Neurogenesis
  • Phagocytosis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

CCL2 affects β-amyloidosis and progressive neurocognitive dysfunction in a mouse model of Alzheimer's disease. / Kiyota, Tomomi; Gendelman, Howard Eliot; Weir, Robert A.; Higgins, E. Elizabeth; Zhang, Gang; Jain, Mohit.

In: Neurobiology of Aging, Vol. 34, No. 4, 01.04.2013, p. 1060-1068.

Research output: Contribution to journalArticle

Kiyota, Tomomi ; Gendelman, Howard Eliot ; Weir, Robert A. ; Higgins, E. Elizabeth ; Zhang, Gang ; Jain, Mohit. / CCL2 affects β-amyloidosis and progressive neurocognitive dysfunction in a mouse model of Alzheimer's disease. In: Neurobiology of Aging. 2013 ; Vol. 34, No. 4. pp. 1060-1068.
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