Caveolin-1 is dispensable for early lymphoid development, but plays a role in the maintenance of the mature splenic microenvironment

Tyler A. Herek, Jacob E. Robinson, Tayla B. Heavican, Catalina Amador, Javeed Iqbal, Christine E Cutucache

Research output: Contribution to journalArticle

Abstract

Objective: Caveolin-1 (CAV1) is known for its role as both a tumor suppressor and an oncogene, harboring a highly context-dependent role within a myriad of malignancies and cell types. In an immunological context, dysregulation of CAV1 expression has been shown to alter immunological signaling functions and suggests a pivotal role for CAV1 in the facilitation of proper immune responses. Nonetheless, it is still unknown how Cav1-deficiency and heterozygosity would impact the development and composition of lymphoid organs in mice. Herein, we investigated the impacts of Cav1-dysregulation on the lymphoid organs in young (12 weeks) and aged (36 weeks) Cav1 +/+, Cav1 +/-, and Cav1 -/- mice. Results: We observed that only Cav1-deficiency is associated with persistent splenomegaly at all timepoints. Furthermore, no differences in overall body weight were detected (and without sexual dimorphisms). Both aged Cav1 +/- and Cav1 -/- mice present with decreased CD19+CD22+ B cells and secondary-follicle atrophy, specifically in the spleen, compared with wild-type controls and irrespective of splenomegaly status. Consequently, the demonstrated effects on B cell homeostasis and secondary follicle characteristics prompted our investigation into follicle-derived human B-cell lymphomas. Our investigation points toward CAV1 as a dysregulated protein in follicle-derived B-cell malignancies without harboring a differential expression between more aggressive and indolent hematological malignancies.

Original languageEnglish (US)
Article number470
JournalBMC Research Notes
Volume11
Issue number1
DOIs
StatePublished - Jul 13 2018

Fingerprint

Caveolin 1
Cells
Maintenance
B-Lymphocytes
Splenomegaly
Neoplasms
B-Cell Lymphoma
Hematologic Neoplasms
Oncogenes
Sex Characteristics
Atrophy
Tumors
Homeostasis
Spleen
Body Weight
Chemical analysis
Proteins

Keywords

  • B cell
  • Caveolin-1
  • Immunophenotype
  • Spleen

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Caveolin-1 is dispensable for early lymphoid development, but plays a role in the maintenance of the mature splenic microenvironment. / Herek, Tyler A.; Robinson, Jacob E.; Heavican, Tayla B.; Amador, Catalina; Iqbal, Javeed; Cutucache, Christine E.

In: BMC Research Notes, Vol. 11, No. 1, 470, 13.07.2018.

Research output: Contribution to journalArticle

@article{04db83e959b24eaf8388a168a735dc69,
title = "Caveolin-1 is dispensable for early lymphoid development, but plays a role in the maintenance of the mature splenic microenvironment",
abstract = "Objective: Caveolin-1 (CAV1) is known for its role as both a tumor suppressor and an oncogene, harboring a highly context-dependent role within a myriad of malignancies and cell types. In an immunological context, dysregulation of CAV1 expression has been shown to alter immunological signaling functions and suggests a pivotal role for CAV1 in the facilitation of proper immune responses. Nonetheless, it is still unknown how Cav1-deficiency and heterozygosity would impact the development and composition of lymphoid organs in mice. Herein, we investigated the impacts of Cav1-dysregulation on the lymphoid organs in young (12 weeks) and aged (36 weeks) Cav1 +/+, Cav1 +/-, and Cav1 -/- mice. Results: We observed that only Cav1-deficiency is associated with persistent splenomegaly at all timepoints. Furthermore, no differences in overall body weight were detected (and without sexual dimorphisms). Both aged Cav1 +/- and Cav1 -/- mice present with decreased CD19+CD22+ B cells and secondary-follicle atrophy, specifically in the spleen, compared with wild-type controls and irrespective of splenomegaly status. Consequently, the demonstrated effects on B cell homeostasis and secondary follicle characteristics prompted our investigation into follicle-derived human B-cell lymphomas. Our investigation points toward CAV1 as a dysregulated protein in follicle-derived B-cell malignancies without harboring a differential expression between more aggressive and indolent hematological malignancies.",
keywords = "B cell, Caveolin-1, Immunophenotype, Spleen",
author = "Herek, {Tyler A.} and Robinson, {Jacob E.} and Heavican, {Tayla B.} and Catalina Amador and Javeed Iqbal and Cutucache, {Christine E}",
year = "2018",
month = "7",
day = "13",
doi = "10.1186/s13104-018-3583-3",
language = "English (US)",
volume = "11",
journal = "BMC Research Notes",
issn = "1756-0500",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Caveolin-1 is dispensable for early lymphoid development, but plays a role in the maintenance of the mature splenic microenvironment

AU - Herek, Tyler A.

AU - Robinson, Jacob E.

AU - Heavican, Tayla B.

AU - Amador, Catalina

AU - Iqbal, Javeed

AU - Cutucache, Christine E

PY - 2018/7/13

Y1 - 2018/7/13

N2 - Objective: Caveolin-1 (CAV1) is known for its role as both a tumor suppressor and an oncogene, harboring a highly context-dependent role within a myriad of malignancies and cell types. In an immunological context, dysregulation of CAV1 expression has been shown to alter immunological signaling functions and suggests a pivotal role for CAV1 in the facilitation of proper immune responses. Nonetheless, it is still unknown how Cav1-deficiency and heterozygosity would impact the development and composition of lymphoid organs in mice. Herein, we investigated the impacts of Cav1-dysregulation on the lymphoid organs in young (12 weeks) and aged (36 weeks) Cav1 +/+, Cav1 +/-, and Cav1 -/- mice. Results: We observed that only Cav1-deficiency is associated with persistent splenomegaly at all timepoints. Furthermore, no differences in overall body weight were detected (and without sexual dimorphisms). Both aged Cav1 +/- and Cav1 -/- mice present with decreased CD19+CD22+ B cells and secondary-follicle atrophy, specifically in the spleen, compared with wild-type controls and irrespective of splenomegaly status. Consequently, the demonstrated effects on B cell homeostasis and secondary follicle characteristics prompted our investigation into follicle-derived human B-cell lymphomas. Our investigation points toward CAV1 as a dysregulated protein in follicle-derived B-cell malignancies without harboring a differential expression between more aggressive and indolent hematological malignancies.

AB - Objective: Caveolin-1 (CAV1) is known for its role as both a tumor suppressor and an oncogene, harboring a highly context-dependent role within a myriad of malignancies and cell types. In an immunological context, dysregulation of CAV1 expression has been shown to alter immunological signaling functions and suggests a pivotal role for CAV1 in the facilitation of proper immune responses. Nonetheless, it is still unknown how Cav1-deficiency and heterozygosity would impact the development and composition of lymphoid organs in mice. Herein, we investigated the impacts of Cav1-dysregulation on the lymphoid organs in young (12 weeks) and aged (36 weeks) Cav1 +/+, Cav1 +/-, and Cav1 -/- mice. Results: We observed that only Cav1-deficiency is associated with persistent splenomegaly at all timepoints. Furthermore, no differences in overall body weight were detected (and without sexual dimorphisms). Both aged Cav1 +/- and Cav1 -/- mice present with decreased CD19+CD22+ B cells and secondary-follicle atrophy, specifically in the spleen, compared with wild-type controls and irrespective of splenomegaly status. Consequently, the demonstrated effects on B cell homeostasis and secondary follicle characteristics prompted our investigation into follicle-derived human B-cell lymphomas. Our investigation points toward CAV1 as a dysregulated protein in follicle-derived B-cell malignancies without harboring a differential expression between more aggressive and indolent hematological malignancies.

KW - B cell

KW - Caveolin-1

KW - Immunophenotype

KW - Spleen

UR - http://www.scopus.com/inward/record.url?scp=85049936022&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049936022&partnerID=8YFLogxK

U2 - 10.1186/s13104-018-3583-3

DO - 10.1186/s13104-018-3583-3

M3 - Article

VL - 11

JO - BMC Research Notes

JF - BMC Research Notes

SN - 1756-0500

IS - 1

M1 - 470

ER -