Cations differentially affect subpopulations of l-glutamate receptors in rat synaptic plasma membranes

E. Edward Mena, Daniel T Monaghan, Scott R. Whittemore, Carl W. Cotman

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Several cations were examined for their ability to specifically affect one of the 3 l-glutamate (l-Glu) binding sites in rat forebrain synaptic plasma membranes (i.e. Na+-dependent, Cl--dependent and Cl--independent). Na+-dependent binding was potently inhibited by K+ and NH4+ ions. Other monovalent cations testedd (Cs+, Li+, triethylammonium) had no effect on this binding site. Polyvalent cations (Co2+, Ni2+, Cu2+, Zn2+, Cd2+ and Cr3+) also had little effect on the Na+-dependent l-Glu binding site. Cl--dependent l-Glu binding was potently inhibited by Na+ ions but was not affected by other monovalent ions. All of the divalent cations were potent inhibitors of both Cl--dependent and -independent binding. The results show that these binding sites of l-Glu can be distinguished by their response to cations and suggest possible novel modes of regulation in vivo.

Original languageEnglish (US)
Pages (from-to)319-322
Number of pages4
JournalBrain Research
Volume329
Issue number1-2
DOIs
StatePublished - Mar 11 1985
Externally publishedYes

Fingerprint

Synaptic Membranes
Glutamate Receptors
Cations
Glutamic Acid
Binding Sites
Cell Membrane
Ions
Monovalent Cations
Divalent Cations
Prosencephalon

Keywords

  • acidic amino acid receptors
  • ammonium ions
  • l-glutamate
  • sodium ions
  • synaptic plasma membranes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Cations differentially affect subpopulations of l-glutamate receptors in rat synaptic plasma membranes. / Mena, E. Edward; Monaghan, Daniel T; Whittemore, Scott R.; Cotman, Carl W.

In: Brain Research, Vol. 329, No. 1-2, 11.03.1985, p. 319-322.

Research output: Contribution to journalArticle

Mena, E. Edward ; Monaghan, Daniel T ; Whittemore, Scott R. ; Cotman, Carl W. / Cations differentially affect subpopulations of l-glutamate receptors in rat synaptic plasma membranes. In: Brain Research. 1985 ; Vol. 329, No. 1-2. pp. 319-322.
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