Cathepsin K inhibitor-polymer conjugates: Potential drugs for the treatment of osteoporosis and rheumatoid arthritis

D. Wang, W. Li, M. Pechar, P. Kopečková, D. Brömme, J. Kopeček

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The role of the newly discovered cysteine protease, cathepsin K, in osteoporosis and rheumatoid arthritis is reviewed. The current development of cathepsin K inhibitors and their targeted delivery using synthetic polymer carriers are discussed. Future challenges and possible strategies to improve these delivery systems are addressed.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalInternational Journal of Pharmaceutics
Volume277
Issue number1-2
DOIs
StatePublished - Jun 11 2004

Fingerprint

Cathepsin K
Osteoporosis
Rheumatoid Arthritis
Polymers
Endopeptidase K
Cysteine Proteases
Pharmaceutical Preparations

Keywords

  • Antiresorptive
  • Cathepsin K
  • Inhibitor-polymer conjugates
  • Resorption lacuna
  • Semitelechelic HPMA polymer
  • mPEG

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Cathepsin K inhibitor-polymer conjugates : Potential drugs for the treatment of osteoporosis and rheumatoid arthritis. / Wang, D.; Li, W.; Pechar, M.; Kopečková, P.; Brömme, D.; Kopeček, J.

In: International Journal of Pharmaceutics, Vol. 277, No. 1-2, 11.06.2004, p. 73-79.

Research output: Contribution to journalArticle

Wang, D. ; Li, W. ; Pechar, M. ; Kopečková, P. ; Brömme, D. ; Kopeček, J. / Cathepsin K inhibitor-polymer conjugates : Potential drugs for the treatment of osteoporosis and rheumatoid arthritis. In: International Journal of Pharmaceutics. 2004 ; Vol. 277, No. 1-2. pp. 73-79.
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