Catalytic cobalt-mediated reductive carbocyclizations

James M Takacs, Steven J. Mehrman

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The cobalt-catalyzed cyclization of certain acyclic enediene substrates proceeds stereoselectively to afford substituted divinyl cyclopentanes and cyclohexanes in good yield. A variation, involving a substrate wherein a suitably disposed alkyne separates the reacting alkene and 1,3-diene partners, affords a novel cascade cyclization product.

Original languageEnglish (US)
Pages (from-to)2749-2752
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number16
DOIs
StatePublished - Apr 15 1996

Fingerprint

Cyclization
Cobalt
Cyclohexanes
Cyclopentanes
Alkynes
Alkenes
Substrates
1,3-butadiene

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Catalytic cobalt-mediated reductive carbocyclizations. / Takacs, James M; Mehrman, Steven J.

In: Tetrahedron Letters, Vol. 37, No. 16, 15.04.1996, p. 2749-2752.

Research output: Contribution to journalArticle

Takacs, James M ; Mehrman, Steven J. / Catalytic cobalt-mediated reductive carbocyclizations. In: Tetrahedron Letters. 1996 ; Vol. 37, No. 16. pp. 2749-2752.
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