"Cassette" in situ enzymatic screening identifies complementary chiral scaffolds for hydrolytic kinetic resolution across a range of epoxides

Sangeeta Dey, Douglas R. Powell, Chunhua Hu, David B Berkowitz

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

(Figure Presented) Put the cassette in: An in situ enzymatic screen can give real-time estimates of the sense and magnitude of enantioselectivity across more than one substrate. Screening identified CoIII-salen catalysts with β-pinene- and α-naphthylalanine-derived chiral scaffolds with broad, yet complementary, substrate specificities. ADH = alcohol dehydrogenase, HL = horse liver, LK = Lactobacillus kefir, salen = (salicylidene) ethylenediamine.

Original languageEnglish (US)
Pages (from-to)7010-7014
Number of pages5
JournalAngewandte Chemie - International Edition
Volume46
Issue number37
DOIs
StatePublished - Oct 3 2007

Fingerprint

ethylenediamine
Epoxy Compounds
Scaffolds
Screening
Kinetics
Alcohol Dehydrogenase
Enantioselectivity
Substrates
Liver
Alcohols
Catalysts
disalicylaldehyde ethylenediamine
Oxidoreductases

Keywords

  • Asymmetric catalysis
  • Cobalt
  • Combinatorial chemistry
  • Enantioselectivity
  • UV/Vis spectroscopy

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

"Cassette" in situ enzymatic screening identifies complementary chiral scaffolds for hydrolytic kinetic resolution across a range of epoxides. / Dey, Sangeeta; Powell, Douglas R.; Hu, Chunhua; Berkowitz, David B.

In: Angewandte Chemie - International Edition, Vol. 46, No. 37, 03.10.2007, p. 7010-7014.

Research output: Contribution to journalArticle

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