CASPASE-12 and rheumatoid arthritis in African-Americans

Laura Marshall, Mohammad Obaidullah, Trista Fuchs, Naomi S. Fineberg, Garland Brinkley, Ted R Mikuls, S. Louis Bridges, Evan Hermel

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

CASPASE-12 (CASP12) has a downregulatory function during infection and thus may protect against inflammatory disease. We investigated the distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). CASP12 alleles were genotyped in 953 RA patients and 342 controls. Statistical analyses comparing genotype groups were performed using Kruskal-Wallis non-parametric ANOVA with Mann-Whitney U tests and chi-square tests. There was no significant difference in the overall distribution of CASP12 genotypes within AA with RA, but CASP12 homozygous patients had lower baseline joint-narrowing scores. CASP12 homozygosity appears to be a subtle protective factor for some aspects of RA in AA patients.

Original languageEnglish (US)
Pages (from-to)281-285
Number of pages5
JournalImmunogenetics
Volume66
Issue number4
DOIs
StatePublished - Jan 1 2014

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African Americans
Rheumatoid Arthritis
Alleles
Genotype
Chi-Square Distribution
Nonparametric Statistics
Analysis of Variance
Joints
Infection

Keywords

  • African-American
  • CASPASE-12
  • Immunogenetics
  • Inflammation
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Marshall, L., Obaidullah, M., Fuchs, T., Fineberg, N. S., Brinkley, G., Mikuls, T. R., ... Hermel, E. (2014). CASPASE-12 and rheumatoid arthritis in African-Americans. Immunogenetics, 66(4), 281-285. https://doi.org/10.1007/s00251-014-0762-9

CASPASE-12 and rheumatoid arthritis in African-Americans. / Marshall, Laura; Obaidullah, Mohammad; Fuchs, Trista; Fineberg, Naomi S.; Brinkley, Garland; Mikuls, Ted R; Bridges, S. Louis; Hermel, Evan.

In: Immunogenetics, Vol. 66, No. 4, 01.01.2014, p. 281-285.

Research output: Contribution to journalArticle

Marshall, L, Obaidullah, M, Fuchs, T, Fineberg, NS, Brinkley, G, Mikuls, TR, Bridges, SL & Hermel, E 2014, 'CASPASE-12 and rheumatoid arthritis in African-Americans', Immunogenetics, vol. 66, no. 4, pp. 281-285. https://doi.org/10.1007/s00251-014-0762-9
Marshall L, Obaidullah M, Fuchs T, Fineberg NS, Brinkley G, Mikuls TR et al. CASPASE-12 and rheumatoid arthritis in African-Americans. Immunogenetics. 2014 Jan 1;66(4):281-285. https://doi.org/10.1007/s00251-014-0762-9
Marshall, Laura ; Obaidullah, Mohammad ; Fuchs, Trista ; Fineberg, Naomi S. ; Brinkley, Garland ; Mikuls, Ted R ; Bridges, S. Louis ; Hermel, Evan. / CASPASE-12 and rheumatoid arthritis in African-Americans. In: Immunogenetics. 2014 ; Vol. 66, No. 4. pp. 281-285.
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