Carotid sinus baroreceptors modulate tracheal smooth muscle tension in dogs

H. D. Schultz, T. E. Pisarri, H. M. Coleridge, J. C.G. Coleridge

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Arterial baroreceptors are known to influence airway smooth muscle tone. Thus, increasing carotid sinus pressure from 20 to 200 mm Hg causes reflex tracheal dilation. However, the effects of changing sinus pressure around a normal arterial pressure set- point of 100 mm Hg have not been examined. In anesthetized, artificially ventilated dogs, the authors distended the vascularly isolated carotid sinuses with a pulsatile pressure and recorded isometric tension in an upper tracheal segment. The aortic nerves were cut. Increasing mean carotid sinus pressure in steps between 100 and 200 mm Hg decreased tracheal tension, heart rate, and arterial blood pressure; decreasing sinus pressure between 100 and 25 mm Hg had the opposite effect. Changing carotid sinus pressure still evoked tracheal responses when systemic arterial pressure was held constant. Increasing and decreasing carotid sinus pulse pressure around a constant mean pressure evoked similar changes in tracheal tension. All reflex effects were abolished by cutting or cooling (0°C) the carotid sinus nerves; tracheal responses were abolished by cutting the laryngeal nerves or administering atropine. When carotid sinus pressure was held at 100 mm Hg, cooling the sinus nerves increased tracheal tension. Changes in tracheal tension evoked by the carotid baroreflex were of comparable magnitude to those triggered by stimulating pulmonary stretch receptors, laryngeal receptors, and pulmonary C-fibers. The authors' results indicate that carotid sinus baroreceptors exert a tonic influence on the upper airways by a vagal cholinergic pathway, increasing and decreasing tracheal smooth muscle tension as blood pressure varies around the normal set-point.

Original languageEnglish (US)
Pages (from-to)337-345
Number of pages9
JournalCirculation Research
Volume60
Issue number3
DOIs
StatePublished - Jan 1 1987

Fingerprint

Carotid Sinus
Muscle Tonus
Pressoreceptors
Smooth Muscle
Dogs
Pressure
Arterial Pressure
Reflex
Pulmonary Stretch Receptors
Laryngeal Nerves
Blood Pressure
Unmyelinated Nerve Fibers
Baroreflex
Atropine
Cholinergic Agents
Dilatation
Heart Rate
Lung

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Carotid sinus baroreceptors modulate tracheal smooth muscle tension in dogs. / Schultz, H. D.; Pisarri, T. E.; Coleridge, H. M.; Coleridge, J. C.G.

In: Circulation Research, Vol. 60, No. 3, 01.01.1987, p. 337-345.

Research output: Contribution to journalArticle

Schultz, H. D. ; Pisarri, T. E. ; Coleridge, H. M. ; Coleridge, J. C.G. / Carotid sinus baroreceptors modulate tracheal smooth muscle tension in dogs. In: Circulation Research. 1987 ; Vol. 60, No. 3. pp. 337-345.
@article{f2097d6a8c3747d586608fa12713711b,
title = "Carotid sinus baroreceptors modulate tracheal smooth muscle tension in dogs",
abstract = "Arterial baroreceptors are known to influence airway smooth muscle tone. Thus, increasing carotid sinus pressure from 20 to 200 mm Hg causes reflex tracheal dilation. However, the effects of changing sinus pressure around a normal arterial pressure set- point of 100 mm Hg have not been examined. In anesthetized, artificially ventilated dogs, the authors distended the vascularly isolated carotid sinuses with a pulsatile pressure and recorded isometric tension in an upper tracheal segment. The aortic nerves were cut. Increasing mean carotid sinus pressure in steps between 100 and 200 mm Hg decreased tracheal tension, heart rate, and arterial blood pressure; decreasing sinus pressure between 100 and 25 mm Hg had the opposite effect. Changing carotid sinus pressure still evoked tracheal responses when systemic arterial pressure was held constant. Increasing and decreasing carotid sinus pulse pressure around a constant mean pressure evoked similar changes in tracheal tension. All reflex effects were abolished by cutting or cooling (0°C) the carotid sinus nerves; tracheal responses were abolished by cutting the laryngeal nerves or administering atropine. When carotid sinus pressure was held at 100 mm Hg, cooling the sinus nerves increased tracheal tension. Changes in tracheal tension evoked by the carotid baroreflex were of comparable magnitude to those triggered by stimulating pulmonary stretch receptors, laryngeal receptors, and pulmonary C-fibers. The authors' results indicate that carotid sinus baroreceptors exert a tonic influence on the upper airways by a vagal cholinergic pathway, increasing and decreasing tracheal smooth muscle tension as blood pressure varies around the normal set-point.",
author = "Schultz, {H. D.} and Pisarri, {T. E.} and Coleridge, {H. M.} and Coleridge, {J. C.G.}",
year = "1987",
month = "1",
day = "1",
doi = "10.1161/01.RES.60.3.337",
language = "English (US)",
volume = "60",
pages = "337--345",
journal = "Circulation Research",
issn = "0009-7330",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Carotid sinus baroreceptors modulate tracheal smooth muscle tension in dogs

AU - Schultz, H. D.

AU - Pisarri, T. E.

AU - Coleridge, H. M.

AU - Coleridge, J. C.G.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Arterial baroreceptors are known to influence airway smooth muscle tone. Thus, increasing carotid sinus pressure from 20 to 200 mm Hg causes reflex tracheal dilation. However, the effects of changing sinus pressure around a normal arterial pressure set- point of 100 mm Hg have not been examined. In anesthetized, artificially ventilated dogs, the authors distended the vascularly isolated carotid sinuses with a pulsatile pressure and recorded isometric tension in an upper tracheal segment. The aortic nerves were cut. Increasing mean carotid sinus pressure in steps between 100 and 200 mm Hg decreased tracheal tension, heart rate, and arterial blood pressure; decreasing sinus pressure between 100 and 25 mm Hg had the opposite effect. Changing carotid sinus pressure still evoked tracheal responses when systemic arterial pressure was held constant. Increasing and decreasing carotid sinus pulse pressure around a constant mean pressure evoked similar changes in tracheal tension. All reflex effects were abolished by cutting or cooling (0°C) the carotid sinus nerves; tracheal responses were abolished by cutting the laryngeal nerves or administering atropine. When carotid sinus pressure was held at 100 mm Hg, cooling the sinus nerves increased tracheal tension. Changes in tracheal tension evoked by the carotid baroreflex were of comparable magnitude to those triggered by stimulating pulmonary stretch receptors, laryngeal receptors, and pulmonary C-fibers. The authors' results indicate that carotid sinus baroreceptors exert a tonic influence on the upper airways by a vagal cholinergic pathway, increasing and decreasing tracheal smooth muscle tension as blood pressure varies around the normal set-point.

AB - Arterial baroreceptors are known to influence airway smooth muscle tone. Thus, increasing carotid sinus pressure from 20 to 200 mm Hg causes reflex tracheal dilation. However, the effects of changing sinus pressure around a normal arterial pressure set- point of 100 mm Hg have not been examined. In anesthetized, artificially ventilated dogs, the authors distended the vascularly isolated carotid sinuses with a pulsatile pressure and recorded isometric tension in an upper tracheal segment. The aortic nerves were cut. Increasing mean carotid sinus pressure in steps between 100 and 200 mm Hg decreased tracheal tension, heart rate, and arterial blood pressure; decreasing sinus pressure between 100 and 25 mm Hg had the opposite effect. Changing carotid sinus pressure still evoked tracheal responses when systemic arterial pressure was held constant. Increasing and decreasing carotid sinus pulse pressure around a constant mean pressure evoked similar changes in tracheal tension. All reflex effects were abolished by cutting or cooling (0°C) the carotid sinus nerves; tracheal responses were abolished by cutting the laryngeal nerves or administering atropine. When carotid sinus pressure was held at 100 mm Hg, cooling the sinus nerves increased tracheal tension. Changes in tracheal tension evoked by the carotid baroreflex were of comparable magnitude to those triggered by stimulating pulmonary stretch receptors, laryngeal receptors, and pulmonary C-fibers. The authors' results indicate that carotid sinus baroreceptors exert a tonic influence on the upper airways by a vagal cholinergic pathway, increasing and decreasing tracheal smooth muscle tension as blood pressure varies around the normal set-point.

UR - http://www.scopus.com/inward/record.url?scp=0023202679&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023202679&partnerID=8YFLogxK

U2 - 10.1161/01.RES.60.3.337

DO - 10.1161/01.RES.60.3.337

M3 - Article

C2 - 3581443

AN - SCOPUS:0023202679

VL - 60

SP - 337

EP - 345

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 3

ER -