Carotid intima media thickness decreases after pancreas transplantation

Jennifer Lynn Larsen, Tanaporn Ratanasuwan, Tab Burkman, Thomas Lynch, Judi Erickson, Christopher Colling, James Lane, Lynn R Mack, Elizabeth Lyden, Melissa Loseke, Suzanne Miller, John Leone

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Background. Pancreas transplantation (PTX) improves diabetic microvascular complications, but it is unknown whether PTX alters macrovascular disease. Carotid intima media thickness (IMT) has been shown to correlate with cardiovascular events, so this study was designed to evaluate changes in carotid IMT after PTX. Methods. Four groups were studied: PTX candidates (n = 60); successful PTX recipients (n = 89; mean time since PTX = 4.0±0.3 years); patients with type 1 diabetes but without nephropathy (n = 20); and normal controls (n = 32). Mean IMT and mean of maximum carotid IMT measurements (mean-max IMT), hemoglobin A1C, serum creatinine, body mass index (BMI), blood pressure, smoking status, use of hypolipidemic medications, and fasting lipids were determined in all groups. Results. Age, gender distribution, and BMI were not different among the groups. Duration of diabetes was also equal between pre- and post-PTX groups. Mean and mean-max IMT were greatest pre-PTX and decreased after PTX (P < 0.05) to a value that was not different from controls. Hemoglobin A1C and creatinine decreased, and high density lipoprotein (HDL) increased after PTX (P < 0.05), but there were no significant differences in other lipids, BMI, use of lipid lowering agents, blood pressure, or smoking status. Conclusions. Carotid IMT is lower after PTX, suggesting a reduction in overall cardiovascular risk independent of changes in use of hypolipidemic agents, smoking, blood pressure, BMI, or lipids, except HDL. Improved carotid IMT after successful PTX predicts a reduction in future vascular disease events and suggests that the macrovascular disease of type 1 diabetes is at least partially reversible with improved glucose control.

Original languageEnglish (US)
Pages (from-to)936-940
Number of pages5
JournalTransplantation
Volume73
Issue number6
DOIs
StatePublished - Mar 27 2002

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Pancreas Transplantation
Carotid Intima-Media Thickness
Body Mass Index
Smoking
HDL Lipoproteins
Blood Pressure
Type 1 Diabetes Mellitus
Lipids
Creatinine
Hemoglobins
Hypolipidemic Agents
Age Distribution
Diabetes Complications
Vascular Diseases
Fasting
Glucose
Serum

ASJC Scopus subject areas

  • Transplantation

Cite this

Larsen, J. L., Ratanasuwan, T., Burkman, T., Lynch, T., Erickson, J., Colling, C., ... Leone, J. (2002). Carotid intima media thickness decreases after pancreas transplantation. Transplantation, 73(6), 936-940. https://doi.org/10.1097/00007890-200203270-00019

Carotid intima media thickness decreases after pancreas transplantation. / Larsen, Jennifer Lynn; Ratanasuwan, Tanaporn; Burkman, Tab; Lynch, Thomas; Erickson, Judi; Colling, Christopher; Lane, James; Mack, Lynn R; Lyden, Elizabeth; Loseke, Melissa; Miller, Suzanne; Leone, John.

In: Transplantation, Vol. 73, No. 6, 27.03.2002, p. 936-940.

Research output: Contribution to journalArticle

Larsen, JL, Ratanasuwan, T, Burkman, T, Lynch, T, Erickson, J, Colling, C, Lane, J, Mack, LR, Lyden, E, Loseke, M, Miller, S & Leone, J 2002, 'Carotid intima media thickness decreases after pancreas transplantation', Transplantation, vol. 73, no. 6, pp. 936-940. https://doi.org/10.1097/00007890-200203270-00019
Larsen JL, Ratanasuwan T, Burkman T, Lynch T, Erickson J, Colling C et al. Carotid intima media thickness decreases after pancreas transplantation. Transplantation. 2002 Mar 27;73(6):936-940. https://doi.org/10.1097/00007890-200203270-00019
Larsen, Jennifer Lynn ; Ratanasuwan, Tanaporn ; Burkman, Tab ; Lynch, Thomas ; Erickson, Judi ; Colling, Christopher ; Lane, James ; Mack, Lynn R ; Lyden, Elizabeth ; Loseke, Melissa ; Miller, Suzanne ; Leone, John. / Carotid intima media thickness decreases after pancreas transplantation. In: Transplantation. 2002 ; Vol. 73, No. 6. pp. 936-940.
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abstract = "Background. Pancreas transplantation (PTX) improves diabetic microvascular complications, but it is unknown whether PTX alters macrovascular disease. Carotid intima media thickness (IMT) has been shown to correlate with cardiovascular events, so this study was designed to evaluate changes in carotid IMT after PTX. Methods. Four groups were studied: PTX candidates (n = 60); successful PTX recipients (n = 89; mean time since PTX = 4.0±0.3 years); patients with type 1 diabetes but without nephropathy (n = 20); and normal controls (n = 32). Mean IMT and mean of maximum carotid IMT measurements (mean-max IMT), hemoglobin A1C, serum creatinine, body mass index (BMI), blood pressure, smoking status, use of hypolipidemic medications, and fasting lipids were determined in all groups. Results. Age, gender distribution, and BMI were not different among the groups. Duration of diabetes was also equal between pre- and post-PTX groups. Mean and mean-max IMT were greatest pre-PTX and decreased after PTX (P < 0.05) to a value that was not different from controls. Hemoglobin A1C and creatinine decreased, and high density lipoprotein (HDL) increased after PTX (P < 0.05), but there were no significant differences in other lipids, BMI, use of lipid lowering agents, blood pressure, or smoking status. Conclusions. Carotid IMT is lower after PTX, suggesting a reduction in overall cardiovascular risk independent of changes in use of hypolipidemic agents, smoking, blood pressure, BMI, or lipids, except HDL. Improved carotid IMT after successful PTX predicts a reduction in future vascular disease events and suggests that the macrovascular disease of type 1 diabetes is at least partially reversible with improved glucose control.",
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AU - Ratanasuwan, Tanaporn

AU - Burkman, Tab

AU - Lynch, Thomas

AU - Erickson, Judi

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AU - Lane, James

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N2 - Background. Pancreas transplantation (PTX) improves diabetic microvascular complications, but it is unknown whether PTX alters macrovascular disease. Carotid intima media thickness (IMT) has been shown to correlate with cardiovascular events, so this study was designed to evaluate changes in carotid IMT after PTX. Methods. Four groups were studied: PTX candidates (n = 60); successful PTX recipients (n = 89; mean time since PTX = 4.0±0.3 years); patients with type 1 diabetes but without nephropathy (n = 20); and normal controls (n = 32). Mean IMT and mean of maximum carotid IMT measurements (mean-max IMT), hemoglobin A1C, serum creatinine, body mass index (BMI), blood pressure, smoking status, use of hypolipidemic medications, and fasting lipids were determined in all groups. Results. Age, gender distribution, and BMI were not different among the groups. Duration of diabetes was also equal between pre- and post-PTX groups. Mean and mean-max IMT were greatest pre-PTX and decreased after PTX (P < 0.05) to a value that was not different from controls. Hemoglobin A1C and creatinine decreased, and high density lipoprotein (HDL) increased after PTX (P < 0.05), but there were no significant differences in other lipids, BMI, use of lipid lowering agents, blood pressure, or smoking status. Conclusions. Carotid IMT is lower after PTX, suggesting a reduction in overall cardiovascular risk independent of changes in use of hypolipidemic agents, smoking, blood pressure, BMI, or lipids, except HDL. Improved carotid IMT after successful PTX predicts a reduction in future vascular disease events and suggests that the macrovascular disease of type 1 diabetes is at least partially reversible with improved glucose control.

AB - Background. Pancreas transplantation (PTX) improves diabetic microvascular complications, but it is unknown whether PTX alters macrovascular disease. Carotid intima media thickness (IMT) has been shown to correlate with cardiovascular events, so this study was designed to evaluate changes in carotid IMT after PTX. Methods. Four groups were studied: PTX candidates (n = 60); successful PTX recipients (n = 89; mean time since PTX = 4.0±0.3 years); patients with type 1 diabetes but without nephropathy (n = 20); and normal controls (n = 32). Mean IMT and mean of maximum carotid IMT measurements (mean-max IMT), hemoglobin A1C, serum creatinine, body mass index (BMI), blood pressure, smoking status, use of hypolipidemic medications, and fasting lipids were determined in all groups. Results. Age, gender distribution, and BMI were not different among the groups. Duration of diabetes was also equal between pre- and post-PTX groups. Mean and mean-max IMT were greatest pre-PTX and decreased after PTX (P < 0.05) to a value that was not different from controls. Hemoglobin A1C and creatinine decreased, and high density lipoprotein (HDL) increased after PTX (P < 0.05), but there were no significant differences in other lipids, BMI, use of lipid lowering agents, blood pressure, or smoking status. Conclusions. Carotid IMT is lower after PTX, suggesting a reduction in overall cardiovascular risk independent of changes in use of hypolipidemic agents, smoking, blood pressure, BMI, or lipids, except HDL. Improved carotid IMT after successful PTX predicts a reduction in future vascular disease events and suggests that the macrovascular disease of type 1 diabetes is at least partially reversible with improved glucose control.

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