Cardiovascular magnetic resonance feature-tracking assessment of myocardial mechanics: Intervendor agreement and considerations regarding reproducibility

A. Schuster, V. C. Stahnke, C. Unterberg-Buchwald, J. T. Kowallick, P. Lamata, M. Steinmetz, Shelby Kutty, M. Fasshauer, W. Staab, J. M. Sohns, B. Bigalke, C. Ritter, G. Hasenfuß, P. Beerbaum, J. Lotz

Research output: Contribution to journalArticle

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Abstract

Aim To assess intervendor agreement of cardiovascular magnetic resonance feature tracking (CMR-FT) and to study the impact of repeated measures on reproducibility. Materials and methods Ten healthy volunteers underwent cine imaging in short-axis orientation at rest and with dobutamine stimulation (10 and 20 μg/kg/min). All images were analysed three times using two types of software (TomTec, Unterschleissheim, Germany and Circle, cvi42, Calgary, Canada) to assess global left ventricular circumferential (Ecc) and radial (Err) strains and torsion. Differences in intra- and interobserver variability within and between software types were assessed based on single and averaged measurements (two and three repetitions with subsequent averaging of results, respectively) as determined by Bland-Altman analysis, intraclass correlation coefficients (ICC), and coefficient of variation (CoV). Results Myocardial strains and torsion significantly increased on dobutamine stimulation with both types of software (p<0.05). Resting Ecc and torsion as well as Ecc values during dobutamine stimulation were lower measured with Circle (p<0.05). Intra- and interobserver variability between software types was lowest for Ecc (ICC 0.81 [0.63-0.91], 0.87 [0.72-0.94] and CoV 12.47% and 14.3%, respectively) irrespective of the number of analysis repetitions. Err and torsion showed higher variability that markedly improved for torsion with repeated analyses and to a lesser extent for Err. On an intravendor level TomTec showed better reproducibility for Ecc and torsion and Circle for Err. Conclusions CMR-FT strain and torsion measurements are subject to considerable intervendor variability, which can be reduced using three analysis repetitions. For both vendors, Ecc qualifies as the most robust parameter with the best agreement, albeit lower Ecc values obtained using Circle, and warrants further investigation of incremental clinical merit.

Original languageEnglish (US)
Pages (from-to)989-998
Number of pages10
JournalClinical Radiology
Volume70
Issue number9
DOIs
StatePublished - Sep 1 2015

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Mechanics
Dobutamine
Magnetic Resonance Spectroscopy
Software
Observer Variation
Canada
Germany
Healthy Volunteers

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Cardiovascular magnetic resonance feature-tracking assessment of myocardial mechanics : Intervendor agreement and considerations regarding reproducibility. / Schuster, A.; Stahnke, V. C.; Unterberg-Buchwald, C.; Kowallick, J. T.; Lamata, P.; Steinmetz, M.; Kutty, Shelby; Fasshauer, M.; Staab, W.; Sohns, J. M.; Bigalke, B.; Ritter, C.; Hasenfuß, G.; Beerbaum, P.; Lotz, J.

In: Clinical Radiology, Vol. 70, No. 9, 01.09.2015, p. 989-998.

Research output: Contribution to journalArticle

Schuster, A, Stahnke, VC, Unterberg-Buchwald, C, Kowallick, JT, Lamata, P, Steinmetz, M, Kutty, S, Fasshauer, M, Staab, W, Sohns, JM, Bigalke, B, Ritter, C, Hasenfuß, G, Beerbaum, P & Lotz, J 2015, 'Cardiovascular magnetic resonance feature-tracking assessment of myocardial mechanics: Intervendor agreement and considerations regarding reproducibility', Clinical Radiology, vol. 70, no. 9, pp. 989-998. https://doi.org/10.1016/j.crad.2015.05.006
Schuster, A. ; Stahnke, V. C. ; Unterberg-Buchwald, C. ; Kowallick, J. T. ; Lamata, P. ; Steinmetz, M. ; Kutty, Shelby ; Fasshauer, M. ; Staab, W. ; Sohns, J. M. ; Bigalke, B. ; Ritter, C. ; Hasenfuß, G. ; Beerbaum, P. ; Lotz, J. / Cardiovascular magnetic resonance feature-tracking assessment of myocardial mechanics : Intervendor agreement and considerations regarding reproducibility. In: Clinical Radiology. 2015 ; Vol. 70, No. 9. pp. 989-998.
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T1 - Cardiovascular magnetic resonance feature-tracking assessment of myocardial mechanics

T2 - Intervendor agreement and considerations regarding reproducibility

AU - Schuster, A.

AU - Stahnke, V. C.

AU - Unterberg-Buchwald, C.

AU - Kowallick, J. T.

AU - Lamata, P.

AU - Steinmetz, M.

AU - Kutty, Shelby

AU - Fasshauer, M.

AU - Staab, W.

AU - Sohns, J. M.

AU - Bigalke, B.

AU - Ritter, C.

AU - Hasenfuß, G.

AU - Beerbaum, P.

AU - Lotz, J.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Aim To assess intervendor agreement of cardiovascular magnetic resonance feature tracking (CMR-FT) and to study the impact of repeated measures on reproducibility. Materials and methods Ten healthy volunteers underwent cine imaging in short-axis orientation at rest and with dobutamine stimulation (10 and 20 μg/kg/min). All images were analysed three times using two types of software (TomTec, Unterschleissheim, Germany and Circle, cvi42, Calgary, Canada) to assess global left ventricular circumferential (Ecc) and radial (Err) strains and torsion. Differences in intra- and interobserver variability within and between software types were assessed based on single and averaged measurements (two and three repetitions with subsequent averaging of results, respectively) as determined by Bland-Altman analysis, intraclass correlation coefficients (ICC), and coefficient of variation (CoV). Results Myocardial strains and torsion significantly increased on dobutamine stimulation with both types of software (p<0.05). Resting Ecc and torsion as well as Ecc values during dobutamine stimulation were lower measured with Circle (p<0.05). Intra- and interobserver variability between software types was lowest for Ecc (ICC 0.81 [0.63-0.91], 0.87 [0.72-0.94] and CoV 12.47% and 14.3%, respectively) irrespective of the number of analysis repetitions. Err and torsion showed higher variability that markedly improved for torsion with repeated analyses and to a lesser extent for Err. On an intravendor level TomTec showed better reproducibility for Ecc and torsion and Circle for Err. Conclusions CMR-FT strain and torsion measurements are subject to considerable intervendor variability, which can be reduced using three analysis repetitions. For both vendors, Ecc qualifies as the most robust parameter with the best agreement, albeit lower Ecc values obtained using Circle, and warrants further investigation of incremental clinical merit.

AB - Aim To assess intervendor agreement of cardiovascular magnetic resonance feature tracking (CMR-FT) and to study the impact of repeated measures on reproducibility. Materials and methods Ten healthy volunteers underwent cine imaging in short-axis orientation at rest and with dobutamine stimulation (10 and 20 μg/kg/min). All images were analysed three times using two types of software (TomTec, Unterschleissheim, Germany and Circle, cvi42, Calgary, Canada) to assess global left ventricular circumferential (Ecc) and radial (Err) strains and torsion. Differences in intra- and interobserver variability within and between software types were assessed based on single and averaged measurements (two and three repetitions with subsequent averaging of results, respectively) as determined by Bland-Altman analysis, intraclass correlation coefficients (ICC), and coefficient of variation (CoV). Results Myocardial strains and torsion significantly increased on dobutamine stimulation with both types of software (p<0.05). Resting Ecc and torsion as well as Ecc values during dobutamine stimulation were lower measured with Circle (p<0.05). Intra- and interobserver variability between software types was lowest for Ecc (ICC 0.81 [0.63-0.91], 0.87 [0.72-0.94] and CoV 12.47% and 14.3%, respectively) irrespective of the number of analysis repetitions. Err and torsion showed higher variability that markedly improved for torsion with repeated analyses and to a lesser extent for Err. On an intravendor level TomTec showed better reproducibility for Ecc and torsion and Circle for Err. Conclusions CMR-FT strain and torsion measurements are subject to considerable intervendor variability, which can be reduced using three analysis repetitions. For both vendors, Ecc qualifies as the most robust parameter with the best agreement, albeit lower Ecc values obtained using Circle, and warrants further investigation of incremental clinical merit.

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