Cardiovascular effects of injection of argipressin into lateral septal nuclei in rats

Lie Gao, Nai Chang Jiang, Qing Hua Luo, Zhu Xia Zhu

Research output: Contribution to journalArticle

Abstract

Aim: To determine whether argipressin (Arg) plays a role in central neural control of cardiovascular function by acting on the lateral septal nuclei (LSN). Methods: Measuring mean arterial blood pressure (MAP) and heart rate (HR) responses followed microinjection of Arg into the LSN of rats anesthetized with urethane. Results: Arg (100, 200, and 400 ng) injected into the LSN produced a dose-dependent hypertension and tachycardia. Maximal changes of MAP were 0.9 ± 0.6, 2.3 ± 1.3, 4.0 ± 1.4 kPa, respectively; maximal changes of HR were 12 ± 27, 50 ± 33, and 89 ± 27 bpm, respectively. Pretreatment of the LSN with a vasopressin 1 type antagonist d (CH2)5Tyr (Me) Arg abolished the MAP and HR responses produced by injection of Arg. Peripheral α-adrenergic blockade with phentolamine blocked the hypertension responses to injection of Arg into the LSN. Conclusion: Arg acts in the region of the LSN to exert a central action on the cardiovascular system that is mediated by stimulation of sympathetic outflow.

Original languageEnglish (US)
Pages (from-to)49-52
Number of pages4
JournalActa Pharmacologica Sinica
Volume17
Issue number1
StatePublished - Jan 1 1996

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Keywords

  • argipressin
  • blood pressure
  • heart rate
  • septal nuclei

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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