Cardiovascular effects and underlying mechanisms of adenosine and its analogues

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Abstract

The present work was aimed to define the cardiovascular effects and underlying mechanisms of adenosine and its analogues. The results showed that (1) adenosine and 2-chloroadenosine could induce an initial increase in MAP mediated by the adenosine A2 receptors in carotid body chemoreceptor, and a subsequent decrease in MAP, being attributed to the adenosine A1 receptors in heart and A2 receptors in blood vessels; (2) N6-cyclopentyladenosine (CPA, a selective adenosine A1 receptor agonist) inhibited the electrophysiological activity of pacemaker cells in sinoatrial node; (3) CPA markedly attenuated the development of early afterdepolarization, delayed afterdepolarization and triggered activity induced by isoproterenol; (4) endogenous adenosine might play an important role in the generation of anoxic bradycardia; (5) activation of adenosine receptors along with an increase in adenosine receptor density during the course of ischemic preconditioning might provide the protective effect on the ischemic heart injury; (6) the cardiovascular effects of adenosine and its analogues were mainly mediated by activation of ATP sensitive K+ channels coupled to adenosine receptors.

Original languageEnglish (US)
Pages (from-to)238-240
Number of pages3
JournalSheng li ke xue jin zhan [Progress in physiology]
Volume27
Issue number3
StatePublished - Jan 1 1996

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Adenosine
Purinergic P1 Receptors
Adenosine A2 Receptors
Adenosine A1 Receptor Agonists
2-Chloroadenosine
Heart Injuries
Adenosine A1 Receptors
Carotid Body
Ischemic Preconditioning
Sinoatrial Node
Bradycardia
Isoproterenol
varespladib methyl
Blood Vessels
Adenosine Triphosphate

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cardiovascular effects and underlying mechanisms of adenosine and its analogues. / Li, Yulong.

In: Sheng li ke xue jin zhan [Progress in physiology], Vol. 27, No. 3, 01.01.1996, p. 238-240.

Research output: Contribution to journalArticle

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