Cardiorespiratory physiology in the safe passage study

protocol, methods and normative values in unexposed infants

PASS Network

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aim: The Safe Passage Study, conducted by the Prenatal Alcohol in SIDS and Stillbirth Network, is investigating contributions of prenatal alcohol exposure to foetal and infant demise. This current report presents physiological data from full-term infants with no prenatal exposure to alcohol or maternal smoking. Methods: Data are from 666 infants from the Northern Plains (North and South Dakota) and South Africa. A standardised protocol assessed cardiorespiratory function during baseline and head-up tilts shortly after birth and at one month of age. Results: Analyses revealed significant increases in heart rate and decreases in BP from the newborn to one-month time period as well as diminished heart rate responses to head-up tilt in one-month-old infants. Conclusion: The Safe Passage Study was successful in characterising physiology in a large number of infants at sites known to have elevated risks for SIDS. Results demonstrate that even with low prenatal adverse exposures, there are significant changes in cardiorespiratory function as infants enter the window of increased risk for SIDS.

Original languageEnglish (US)
Pages (from-to)1260-1272
Number of pages13
JournalActa Paediatrica, International Journal of Paediatrics
Volume106
Issue number8
DOIs
StatePublished - Aug 1 2017

Fingerprint

Sudden Infant Death
Alcohols
Heart Rate
Head
Fetal Death
Stillbirth
South Africa
Smoking
Mothers
Parturition
Newborn Infant

Keywords

  • Autonomic development
  • Blood pressure
  • Heart rate
  • Respiration
  • SIDS

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Cardiorespiratory physiology in the safe passage study : protocol, methods and normative values in unexposed infants. / PASS Network.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 106, No. 8, 01.08.2017, p. 1260-1272.

Research output: Contribution to journalArticle

@article{7246cabfa7fb4b64ad8e9351a566dff6,
title = "Cardiorespiratory physiology in the safe passage study: protocol, methods and normative values in unexposed infants",
abstract = "Aim: The Safe Passage Study, conducted by the Prenatal Alcohol in SIDS and Stillbirth Network, is investigating contributions of prenatal alcohol exposure to foetal and infant demise. This current report presents physiological data from full-term infants with no prenatal exposure to alcohol or maternal smoking. Methods: Data are from 666 infants from the Northern Plains (North and South Dakota) and South Africa. A standardised protocol assessed cardiorespiratory function during baseline and head-up tilts shortly after birth and at one month of age. Results: Analyses revealed significant increases in heart rate and decreases in BP from the newborn to one-month time period as well as diminished heart rate responses to head-up tilt in one-month-old infants. Conclusion: The Safe Passage Study was successful in characterising physiology in a large number of infants at sites known to have elevated risks for SIDS. Results demonstrate that even with low prenatal adverse exposures, there are significant changes in cardiorespiratory function as infants enter the window of increased risk for SIDS.",
keywords = "Autonomic development, Blood pressure, Heart rate, Respiration, SIDS",
author = "{PASS Network} and Myers, {Michael M.} and Amy Elliott and Odendaal, {Hein J.} and Larry Burd and Jyoti Angal and Coen Groenewald and Nugent, {James David} and Yang, {Joel S.} and Isler, {Joseph R.} and Dukes, {Kim A.} and Fay Robinson and Fifer, {William P.} and Sullivan, {Lisa M.} and Tara Tripp and Petersen, {Julie M.} and Young, {Rebecca A.} and Travis Baker and Derek Petersen and Gregory Toland and Kinney, {Hannah C.} and Haynes, {Robin L.} and Paterson, {David S.} and Broadbelt, {Kevin G.} and Kyriacos Markianos and Holm, {Ingrid A.} and Theonia Boyd and Drucilla Roberts and Goldstein, {Richard G.} and Hanno Stein and Claire Maggiotto and Catherine Hassett and Donald Habbe and {Eugene Hoyme}, H. and Illiam Massello and Bradley Randall and Sens, {Mary Ann} and Catherine Stoos and {Van Eerden}, Peter and Whitney Adler and Elizabeth Berg and Jessica Gromer and Bethany Norton and Liz Swenson and Deb Tobacco and Erna Carstens and Jean Coldray and Mandy Potter and Lucy Brink and Rosemary Meyer and Plessis, {Carlie du}",
year = "2017",
month = "8",
day = "1",
doi = "10.1111/apa.13873",
language = "English (US)",
volume = "106",
pages = "1260--1272",
journal = "Acta Paediatrica, International Journal of Paediatrics",
issn = "0803-5253",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Cardiorespiratory physiology in the safe passage study

T2 - protocol, methods and normative values in unexposed infants

AU - PASS Network

AU - Myers, Michael M.

AU - Elliott, Amy

AU - Odendaal, Hein J.

AU - Burd, Larry

AU - Angal, Jyoti

AU - Groenewald, Coen

AU - Nugent, James David

AU - Yang, Joel S.

AU - Isler, Joseph R.

AU - Dukes, Kim A.

AU - Robinson, Fay

AU - Fifer, William P.

AU - Sullivan, Lisa M.

AU - Tripp, Tara

AU - Petersen, Julie M.

AU - Young, Rebecca A.

AU - Baker, Travis

AU - Petersen, Derek

AU - Toland, Gregory

AU - Kinney, Hannah C.

AU - Haynes, Robin L.

AU - Paterson, David S.

AU - Broadbelt, Kevin G.

AU - Markianos, Kyriacos

AU - Holm, Ingrid A.

AU - Boyd, Theonia

AU - Roberts, Drucilla

AU - Goldstein, Richard G.

AU - Stein, Hanno

AU - Maggiotto, Claire

AU - Hassett, Catherine

AU - Habbe, Donald

AU - Eugene Hoyme, H.

AU - Massello, Illiam

AU - Randall, Bradley

AU - Sens, Mary Ann

AU - Stoos, Catherine

AU - Van Eerden, Peter

AU - Adler, Whitney

AU - Berg, Elizabeth

AU - Gromer, Jessica

AU - Norton, Bethany

AU - Swenson, Liz

AU - Tobacco, Deb

AU - Carstens, Erna

AU - Coldray, Jean

AU - Potter, Mandy

AU - Brink, Lucy

AU - Meyer, Rosemary

AU - Plessis, Carlie du

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Aim: The Safe Passage Study, conducted by the Prenatal Alcohol in SIDS and Stillbirth Network, is investigating contributions of prenatal alcohol exposure to foetal and infant demise. This current report presents physiological data from full-term infants with no prenatal exposure to alcohol or maternal smoking. Methods: Data are from 666 infants from the Northern Plains (North and South Dakota) and South Africa. A standardised protocol assessed cardiorespiratory function during baseline and head-up tilts shortly after birth and at one month of age. Results: Analyses revealed significant increases in heart rate and decreases in BP from the newborn to one-month time period as well as diminished heart rate responses to head-up tilt in one-month-old infants. Conclusion: The Safe Passage Study was successful in characterising physiology in a large number of infants at sites known to have elevated risks for SIDS. Results demonstrate that even with low prenatal adverse exposures, there are significant changes in cardiorespiratory function as infants enter the window of increased risk for SIDS.

AB - Aim: The Safe Passage Study, conducted by the Prenatal Alcohol in SIDS and Stillbirth Network, is investigating contributions of prenatal alcohol exposure to foetal and infant demise. This current report presents physiological data from full-term infants with no prenatal exposure to alcohol or maternal smoking. Methods: Data are from 666 infants from the Northern Plains (North and South Dakota) and South Africa. A standardised protocol assessed cardiorespiratory function during baseline and head-up tilts shortly after birth and at one month of age. Results: Analyses revealed significant increases in heart rate and decreases in BP from the newborn to one-month time period as well as diminished heart rate responses to head-up tilt in one-month-old infants. Conclusion: The Safe Passage Study was successful in characterising physiology in a large number of infants at sites known to have elevated risks for SIDS. Results demonstrate that even with low prenatal adverse exposures, there are significant changes in cardiorespiratory function as infants enter the window of increased risk for SIDS.

KW - Autonomic development

KW - Blood pressure

KW - Heart rate

KW - Respiration

KW - SIDS

UR - http://www.scopus.com/inward/record.url?scp=85019230004&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019230004&partnerID=8YFLogxK

U2 - 10.1111/apa.13873

DO - 10.1111/apa.13873

M3 - Article

VL - 106

SP - 1260

EP - 1272

JO - Acta Paediatrica, International Journal of Paediatrics

JF - Acta Paediatrica, International Journal of Paediatrics

SN - 0803-5253

IS - 8

ER -