Cardiopulmonary vagal affarents in the monkey: A survey of receptor activity

Irving H Zucker, J. P. Gilmore

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These consisted of 347 pulmonary stretch receptors (one of which increased its discharge during expiration), 42 aortic baroreceptors, 4 ventricular pressure receptors, 1 epicardial ventricular receptor, 7 type A atrial receptors and 24 type B atrial receptors. The response of each cardiovascular receptor was tested by altering the stimulus for their discharge. Aortic and ventricular baroreceptors increased their discharge in response to an increase in blood pressure induced by intravenous norepinephrine. Type A atrial receptors did not increase their discharge in response to an increase in atrial pressure during intravenous administration of isotonic saline, while type B atrial receptors did. The discharge of the latter became continuous following the intravenous administration of veratridine sulphate (20 μg). It is concluded that the basic types of cardiopulmonary afferents exist in the non-human primate and that they respond similarly to those which have been demonstrated in lower species.

Original languageEnglish (US)
Pages (from-to)392-401
Number of pages10
JournalBasic research in cardiology
Volume72
Issue number4
DOIs
StatePublished - Jul 1 1977

Fingerprint

Pressoreceptors
Intravenous Administration
Haplorhini
Pulmonary Stretch Receptors
Veratridine
Atrial Pressure
Ventricular Pressure
Macaca mulatta
Primates
Action Potentials
Sulfates
Norepinephrine
Thorax
Blood Pressure
Surveys and Questionnaires

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Cardiopulmonary vagal affarents in the monkey : A survey of receptor activity. / Zucker, Irving H; Gilmore, J. P.

In: Basic research in cardiology, Vol. 72, No. 4, 01.07.1977, p. 392-401.

Research output: Contribution to journalArticle

@article{fb69967107db4cc9b70851ae709b08e1,
title = "Cardiopulmonary vagal affarents in the monkey: A survey of receptor activity",
abstract = "A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These consisted of 347 pulmonary stretch receptors (one of which increased its discharge during expiration), 42 aortic baroreceptors, 4 ventricular pressure receptors, 1 epicardial ventricular receptor, 7 type A atrial receptors and 24 type B atrial receptors. The response of each cardiovascular receptor was tested by altering the stimulus for their discharge. Aortic and ventricular baroreceptors increased their discharge in response to an increase in blood pressure induced by intravenous norepinephrine. Type A atrial receptors did not increase their discharge in response to an increase in atrial pressure during intravenous administration of isotonic saline, while type B atrial receptors did. The discharge of the latter became continuous following the intravenous administration of veratridine sulphate (20 μg). It is concluded that the basic types of cardiopulmonary afferents exist in the non-human primate and that they respond similarly to those which have been demonstrated in lower species.",
author = "Zucker, {Irving H} and Gilmore, {J. P.}",
year = "1977",
month = "7",
day = "1",
doi = "10.1007/BF02023598",
language = "English (US)",
volume = "72",
pages = "392--401",
journal = "Basic Research in Cardiology",
issn = "0300-8428",
publisher = "D. Steinkopff-Verlag",
number = "4",

}

TY - JOUR

T1 - Cardiopulmonary vagal affarents in the monkey

T2 - A survey of receptor activity

AU - Zucker, Irving H

AU - Gilmore, J. P.

PY - 1977/7/1

Y1 - 1977/7/1

N2 - A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These consisted of 347 pulmonary stretch receptors (one of which increased its discharge during expiration), 42 aortic baroreceptors, 4 ventricular pressure receptors, 1 epicardial ventricular receptor, 7 type A atrial receptors and 24 type B atrial receptors. The response of each cardiovascular receptor was tested by altering the stimulus for their discharge. Aortic and ventricular baroreceptors increased their discharge in response to an increase in blood pressure induced by intravenous norepinephrine. Type A atrial receptors did not increase their discharge in response to an increase in atrial pressure during intravenous administration of isotonic saline, while type B atrial receptors did. The discharge of the latter became continuous following the intravenous administration of veratridine sulphate (20 μg). It is concluded that the basic types of cardiopulmonary afferents exist in the non-human primate and that they respond similarly to those which have been demonstrated in lower species.

AB - A survey was made of vagal afferents whose endings originated in cardiopulmonary areas of the Rhesus monkey. Recordings of action potentials from single fiber preparations of the left cervical vagus were made in both open and closed chest monkeys. A total of 425 receptors were identified in sixteen animals. These consisted of 347 pulmonary stretch receptors (one of which increased its discharge during expiration), 42 aortic baroreceptors, 4 ventricular pressure receptors, 1 epicardial ventricular receptor, 7 type A atrial receptors and 24 type B atrial receptors. The response of each cardiovascular receptor was tested by altering the stimulus for their discharge. Aortic and ventricular baroreceptors increased their discharge in response to an increase in blood pressure induced by intravenous norepinephrine. Type A atrial receptors did not increase their discharge in response to an increase in atrial pressure during intravenous administration of isotonic saline, while type B atrial receptors did. The discharge of the latter became continuous following the intravenous administration of veratridine sulphate (20 μg). It is concluded that the basic types of cardiopulmonary afferents exist in the non-human primate and that they respond similarly to those which have been demonstrated in lower species.

UR - http://www.scopus.com/inward/record.url?scp=0017647737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017647737&partnerID=8YFLogxK

U2 - 10.1007/BF02023598

DO - 10.1007/BF02023598

M3 - Article

C2 - 409390

AN - SCOPUS:0017647737

VL - 72

SP - 392

EP - 401

JO - Basic Research in Cardiology

JF - Basic Research in Cardiology

SN - 0300-8428

IS - 4

ER -