Cardiac wound healing post-myocardial infarction

A novel method to target extracellular matrix remodeling in the left ventricle

Rogelio Zamilpa, Jianhua Zhang, Ying Ann Chiao, Lisandra E. De Castro Brás, Ganesh V. Halade, Yonggang Ma, Sander O. Hacker, Merry L Lindsey

Research output: Chapter in Book/Report/Conference proceedingChapter

11 Citations (Scopus)

Abstract

Myocardial infarction (MI) is a leading cause of death worldwide. Permanent ligation of the left anterior descending coronary artery (LAD) is a commonly used surgical model to study post-MI effects in mice. LAD occlusion induces a robust wound healing response that includes extracellular matrix (ECM) remodeling. This chapter provides a detailed guide on the surgical procedure to permanently ligate the LAD. Additionally, we describe a prototype method to enrich cardiac tissue for ECM, which allows one to focus on ECM remodeling in the left ventricle following surgically induced MI in mice.

Original languageEnglish (US)
Title of host publicationWound Regeneration and Repair
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages313-324
Number of pages12
ISBN (Print)9781627035040
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1037
ISSN (Print)1064-3745

Fingerprint

Ventricular Remodeling
Wound Healing
Extracellular Matrix
Myocardial Infarction
Anatomic Models
Ligation
Cause of Death
Coronary Vessels

Keywords

  • Cardiac wound healing
  • Decellularization
  • Extracellular matrix
  • Inflammation
  • Matrix metalloproteinases
  • Mice
  • Myocardial infarction

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Zamilpa, R., Zhang, J., Chiao, Y. A., De Castro Brás, L. E., Halade, G. V., Ma, Y., ... Lindsey, M. L. (2013). Cardiac wound healing post-myocardial infarction: A novel method to target extracellular matrix remodeling in the left ventricle. In Wound Regeneration and Repair: Methods and Protocols (pp. 313-324). (Methods in Molecular Biology; Vol. 1037). Humana Press Inc.. https://doi.org/10.1007/978-1-62703-505-7_18

Cardiac wound healing post-myocardial infarction : A novel method to target extracellular matrix remodeling in the left ventricle. / Zamilpa, Rogelio; Zhang, Jianhua; Chiao, Ying Ann; De Castro Brás, Lisandra E.; Halade, Ganesh V.; Ma, Yonggang; Hacker, Sander O.; Lindsey, Merry L.

Wound Regeneration and Repair: Methods and Protocols. Humana Press Inc., 2013. p. 313-324 (Methods in Molecular Biology; Vol. 1037).

Research output: Chapter in Book/Report/Conference proceedingChapter

Zamilpa, R, Zhang, J, Chiao, YA, De Castro Brás, LE, Halade, GV, Ma, Y, Hacker, SO & Lindsey, ML 2013, Cardiac wound healing post-myocardial infarction: A novel method to target extracellular matrix remodeling in the left ventricle. in Wound Regeneration and Repair: Methods and Protocols. Methods in Molecular Biology, vol. 1037, Humana Press Inc., pp. 313-324. https://doi.org/10.1007/978-1-62703-505-7_18
Zamilpa R, Zhang J, Chiao YA, De Castro Brás LE, Halade GV, Ma Y et al. Cardiac wound healing post-myocardial infarction: A novel method to target extracellular matrix remodeling in the left ventricle. In Wound Regeneration and Repair: Methods and Protocols. Humana Press Inc. 2013. p. 313-324. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-62703-505-7_18
Zamilpa, Rogelio ; Zhang, Jianhua ; Chiao, Ying Ann ; De Castro Brás, Lisandra E. ; Halade, Ganesh V. ; Ma, Yonggang ; Hacker, Sander O. ; Lindsey, Merry L. / Cardiac wound healing post-myocardial infarction : A novel method to target extracellular matrix remodeling in the left ventricle. Wound Regeneration and Repair: Methods and Protocols. Humana Press Inc., 2013. pp. 313-324 (Methods in Molecular Biology).
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