Cardiac sympathetic afferent stimulation augments the arterial chemoreceptor reflex in anesthetized rats

Lie Gao, Yan Xia Pan, Wei Zhong Wang, Yulong Li, Harold D Schultz, Irving H Zucker, Wei Wang

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Chronic heart failure (CHF) is well known to be associated with both an enhanced chemoreceptor reflex and an augmented cardiac "sympathetic afferent reflex" (CSAR). The augmentation of the CSAR may play an important role in the enhanced chemoreceptor reflex in the CHF state because the same central areas are involved in the sympathetic outputs of both reflexes. We determined whether chemical and electrical stimulation of the CSAR augments chemoreceptor reflex function in normal rats. Under anesthesia, renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) were recorded. The chemoreceptor reflex was tested by unilateral intra-carotid artery bolus injection of potassium cyanide (KCN) and nicotine. We found that 1) left ventricular epicardial application of capsaicin increased the pressor responses and the RSNA responses to chemoreflex activation induced by both KCN and nicotine; 2) when the central end of the left cardiac sympathetic nerve was electrically stimulated, both the pressor and the RSNA responses to chemoreflex activation induced by KCN were increased; 3) pretreatment with intracerebroventricular injection of losartan (500 nmol) completely prevented the enhanced chemoreceptor reflex induced by electrical stimulation of the cardiac sympathetic nerve; and 4) bilateral microinjection of losartan (250 pmol) into the nucleus tractus solitarii (NTS) completely abolished the enhanced chemoreceptor reflex by epicardial application of capsaicin. These results suggest that both the chemical and electrical stimulation of the CSAR augments chemoreceptor reflex and that central ANG II, specially located in the NTS, plays a major role in these reflex interactions.

Original languageEnglish (US)
Pages (from-to)37-43
Number of pages7
JournalJournal of Applied Physiology
Volume102
Issue number1
DOIs
StatePublished - Jan 1 2007

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Reflex
Chemical Stimulation
Electric Stimulation
Solitary Nucleus
Losartan
Capsaicin
Nicotine
Kidney
Heart Failure
Potassium Cyanide
Injections
Microinjections
Carotid Arteries
Arterial Pressure
Anesthesia

Keywords

  • AT receptor
  • Cardiac sympathetic afferent reflex
  • Mean arterial pressure
  • Renal sympathetic nerve activity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Cardiac sympathetic afferent stimulation augments the arterial chemoreceptor reflex in anesthetized rats. / Gao, Lie; Pan, Yan Xia; Wang, Wei Zhong; Li, Yulong; Schultz, Harold D; Zucker, Irving H; Wang, Wei.

In: Journal of Applied Physiology, Vol. 102, No. 1, 01.01.2007, p. 37-43.

Research output: Contribution to journalArticle

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