Cardiac sympathetic afferent reflex responses to epicardial application of adenosine is enhanced in dogs with heart failure

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Abstract

Adenosine is an endogenous metabolite capable of stimulating cardiac sympathetic afférents. The purpose of this study was to compare cardiac sympathetic afferent reflex responses to epicardial application of adenosine. Ventricular pacing was carried out in 7 dogs until signs of HF were evident. Eight sham dogs served as controls. At the time of the acute experiment the dogs were anesthetized with chkjratose. The mean arterial pressure (MAP), heart rate (HR) and renal sympathetic nerve (RNA) responses to left ventricular application of adenosine (200 pg in 0.5 ml] were determined in the sino-aortic denervated and vagotomized state. The responses to adenosine are shown in the table below. Change in MAP(mmHg) RNA (% of CM) HR(BPM) Sham 0.8 ±1.9 7.212.1 0.6 ±0.4 HF 1.3 ±0.7 15.9±1.7' 1,4 ±0.4P<0.05, compared with sham group. These enhanced cardiac sympathetic afferent reflex responses to adenosine were more sensitive after adenosine re-uptake blocker, dipyridamole (0.6 mg/kg, iv) in the heart failure group and could be prevented by the adenosine receptor antagonist, aminophyllin (5 mgAg, iv). These data suggest that there is an enhancement of the reflex response to topical application of adenosine in dogs with HF.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - Dec 1 1996

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Adenosine
Reflex
Heart Failure
Dogs
Arterial Pressure
Heart Rate
RNA
Purinergic P1 Receptor Antagonists
Aminophylline
Dipyridamole
Metabolites
Kidney
Experiments

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

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title = "Cardiac sympathetic afferent reflex responses to epicardial application of adenosine is enhanced in dogs with heart failure",
abstract = "Adenosine is an endogenous metabolite capable of stimulating cardiac sympathetic aff{\'e}rents. The purpose of this study was to compare cardiac sympathetic afferent reflex responses to epicardial application of adenosine. Ventricular pacing was carried out in 7 dogs until signs of HF were evident. Eight sham dogs served as controls. At the time of the acute experiment the dogs were anesthetized with chkjratose. The mean arterial pressure (MAP), heart rate (HR) and renal sympathetic nerve (RNA) responses to left ventricular application of adenosine (200 pg in 0.5 ml] were determined in the sino-aortic denervated and vagotomized state. The responses to adenosine are shown in the table below. Change in MAP(mmHg) RNA ({\%} of CM) HR(BPM) Sham 0.8 ±1.9 7.212.1 0.6 ±0.4 HF 1.3 ±0.7 15.9±1.7' 1,4 ±0.4P<0.05, compared with sham group. These enhanced cardiac sympathetic afferent reflex responses to adenosine were more sensitive after adenosine re-uptake blocker, dipyridamole (0.6 mg/kg, iv) in the heart failure group and could be prevented by the adenosine receptor antagonist, aminophyllin (5 mgAg, iv). These data suggest that there is an enhancement of the reflex response to topical application of adenosine in dogs with HF.",
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AU - Zucker, Irving H

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N2 - Adenosine is an endogenous metabolite capable of stimulating cardiac sympathetic afférents. The purpose of this study was to compare cardiac sympathetic afferent reflex responses to epicardial application of adenosine. Ventricular pacing was carried out in 7 dogs until signs of HF were evident. Eight sham dogs served as controls. At the time of the acute experiment the dogs were anesthetized with chkjratose. The mean arterial pressure (MAP), heart rate (HR) and renal sympathetic nerve (RNA) responses to left ventricular application of adenosine (200 pg in 0.5 ml] were determined in the sino-aortic denervated and vagotomized state. The responses to adenosine are shown in the table below. Change in MAP(mmHg) RNA (% of CM) HR(BPM) Sham 0.8 ±1.9 7.212.1 0.6 ±0.4 HF 1.3 ±0.7 15.9±1.7' 1,4 ±0.4P<0.05, compared with sham group. These enhanced cardiac sympathetic afferent reflex responses to adenosine were more sensitive after adenosine re-uptake blocker, dipyridamole (0.6 mg/kg, iv) in the heart failure group and could be prevented by the adenosine receptor antagonist, aminophyllin (5 mgAg, iv). These data suggest that there is an enhancement of the reflex response to topical application of adenosine in dogs with HF.

AB - Adenosine is an endogenous metabolite capable of stimulating cardiac sympathetic afférents. The purpose of this study was to compare cardiac sympathetic afferent reflex responses to epicardial application of adenosine. Ventricular pacing was carried out in 7 dogs until signs of HF were evident. Eight sham dogs served as controls. At the time of the acute experiment the dogs were anesthetized with chkjratose. The mean arterial pressure (MAP), heart rate (HR) and renal sympathetic nerve (RNA) responses to left ventricular application of adenosine (200 pg in 0.5 ml] were determined in the sino-aortic denervated and vagotomized state. The responses to adenosine are shown in the table below. Change in MAP(mmHg) RNA (% of CM) HR(BPM) Sham 0.8 ±1.9 7.212.1 0.6 ±0.4 HF 1.3 ±0.7 15.9±1.7' 1,4 ±0.4P<0.05, compared with sham group. These enhanced cardiac sympathetic afferent reflex responses to adenosine were more sensitive after adenosine re-uptake blocker, dipyridamole (0.6 mg/kg, iv) in the heart failure group and could be prevented by the adenosine receptor antagonist, aminophyllin (5 mgAg, iv). These data suggest that there is an enhancement of the reflex response to topical application of adenosine in dogs with HF.

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