Cardiac matrix

A clue for future therapy

Paras Kumar Mishra, Srikanth Givvimani, Vishalakshi Chavali, Suresh C. Tyagi

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

Cardiac muscle is unique because it contracts ceaselessly throughout the life and is highly resistant to fatigue. The marvelous nature of the cardiac muscle is attributed to its matrix that maintains structural and functional integrity and provides ambient micro-environment required for mechanical, cellular and molecular activities in the heart. Cardiac matrix dictates the endothelium myocyte (EM) coupling and contractility of cardiomyocytes. The matrix metalloproteinases (MMPs) and their tissue inhibitor of metalloproteinases (TIMPs) regulate matrix degradation that determines cardiac fibrosis and myocardial performance. We have shown that MMP-9 regulates differential expression of micro RNAs (miRNAs), calcium cycling and contractility of cardiomyocytes. The differential expression of miRNAs is associated with angiogenesis, hypertrophy and fibrosis in the heart. MMP-9, which is involved in the degradation of cardiac matrix and induction of fibrosis, is also implicated in inhibition of survival and differentiation of cardiac stem cells (CSC). Cardiac matrix is distinct because it renders mechanical properties and provides a framework essential for differentiation of cardiac progenitor cells (CPC) into specific lineage. Cardiac matrix regulates myocyte contractility by EM coupling and calcium transients and also directs miRNAs required for precise regulation of continuous and synchronized beating of cardiomyocytes that is indispensible for survival. Alteration in the matrix homeostasis due to induction of MMPs, altered expression of specific miRNAs or impaired signaling for contractility of cardiomyocytes leads to catastrophic effects. This review describes the mechanisms by which cardiac matrix regulates myocardial performance and suggests future directions for the development of treatment strategies in cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)2271-2276
Number of pages6
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1832
Issue number12
DOIs
StatePublished - Dec 1 2013

Fingerprint

MicroRNAs
Cardiac Myocytes
Muscle Cells
Fibrosis
Matrix Metalloproteinase 9
Matrix Metalloproteinases
Endothelium
Myocardium
Stem Cells
Calcium
Tissue Inhibitor of Metalloproteinases
Therapeutics
Hypertrophy
Fatigue
Homeostasis
Cardiovascular Diseases

Keywords

  • Angiogenesis
  • Heart
  • MMP
  • MiRNA
  • Stem cell
  • TIMP

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

Cite this

Cardiac matrix : A clue for future therapy. / Mishra, Paras Kumar; Givvimani, Srikanth; Chavali, Vishalakshi; Tyagi, Suresh C.

In: Biochimica et Biophysica Acta - Molecular Basis of Disease, Vol. 1832, No. 12, 01.12.2013, p. 2271-2276.

Research output: Contribution to journalReview article

Mishra, Paras Kumar ; Givvimani, Srikanth ; Chavali, Vishalakshi ; Tyagi, Suresh C. / Cardiac matrix : A clue for future therapy. In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 2013 ; Vol. 1832, No. 12. pp. 2271-2276.
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