Carcinogenicity of Formic Acid 2-[4-(5-Nitro-2-furyl)-2-thiazolyl]-hydrazide in Swiss Mice

S. M. Cohen, E. Ertiirk, George T. Bryan

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl] hydrazide was fed to 50 female 5-week-old Swiss mice at a dose of 0.1% by weight of diet for a total of 29 weeks, with a cumulative dose of 1.2 g/mouse/29 weeks. Because of acute toxicity of the chemical and cannibalization by other mice, only 22 of 50 mice survived to the end of feeding and were evaluated. Fifty-six control mice received control diet, and 44 survived and were evaluated. Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl] hydrazide appeared to be a strong carcinogenic (21/22) and leukemogenic (19/22) chemical in this animal species. The solid tumors induced included squamous cell and adenocarcinoma of the stomach (21/22), alveolar lung carcinomas (9/22), mammary adenocarcinomas (7/22), and single tumors of the uterus and skin. In the control mice, the following tumor incidences were found: generalized leukemias, 15/44; and lung, 1/44.

Original languageEnglish (US)
Pages (from-to)906-912
Number of pages7
JournalCancer Research
Volume30
Issue number4
StatePublished - Apr 1970

Fingerprint

Adenocarcinoma
Bronchiolo-Alveolar Adenocarcinoma
Diet
Neoplasms
Lung
Uterus
nefurthiazole
Stomach
Leukemia
Breast
Epithelial Cells
Weights and Measures
Skin
Incidence

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Carcinogenicity of Formic Acid 2-[4-(5-Nitro-2-furyl)-2-thiazolyl]-hydrazide in Swiss Mice. / Cohen, S. M.; Ertiirk, E.; Bryan, George T.

In: Cancer Research, Vol. 30, No. 4, 04.1970, p. 906-912.

Research output: Contribution to journalArticle

Cohen, S. M. ; Ertiirk, E. ; Bryan, George T. / Carcinogenicity of Formic Acid 2-[4-(5-Nitro-2-furyl)-2-thiazolyl]-hydrazide in Swiss Mice. In: Cancer Research. 1970 ; Vol. 30, No. 4. pp. 906-912.
@article{dc36c336b0514f6baf44c307e7a10193,
title = "Carcinogenicity of Formic Acid 2-[4-(5-Nitro-2-furyl)-2-thiazolyl]-hydrazide in Swiss Mice",
abstract = "Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl] hydrazide was fed to 50 female 5-week-old Swiss mice at a dose of 0.1{\%} by weight of diet for a total of 29 weeks, with a cumulative dose of 1.2 g/mouse/29 weeks. Because of acute toxicity of the chemical and cannibalization by other mice, only 22 of 50 mice survived to the end of feeding and were evaluated. Fifty-six control mice received control diet, and 44 survived and were evaluated. Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl] hydrazide appeared to be a strong carcinogenic (21/22) and leukemogenic (19/22) chemical in this animal species. The solid tumors induced included squamous cell and adenocarcinoma of the stomach (21/22), alveolar lung carcinomas (9/22), mammary adenocarcinomas (7/22), and single tumors of the uterus and skin. In the control mice, the following tumor incidences were found: generalized leukemias, 15/44; and lung, 1/44.",
author = "Cohen, {S. M.} and E. Ertiirk and Bryan, {George T.}",
year = "1970",
month = "4",
language = "English (US)",
volume = "30",
pages = "906--912",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "4",

}

TY - JOUR

T1 - Carcinogenicity of Formic Acid 2-[4-(5-Nitro-2-furyl)-2-thiazolyl]-hydrazide in Swiss Mice

AU - Cohen, S. M.

AU - Ertiirk, E.

AU - Bryan, George T.

PY - 1970/4

Y1 - 1970/4

N2 - Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl] hydrazide was fed to 50 female 5-week-old Swiss mice at a dose of 0.1% by weight of diet for a total of 29 weeks, with a cumulative dose of 1.2 g/mouse/29 weeks. Because of acute toxicity of the chemical and cannibalization by other mice, only 22 of 50 mice survived to the end of feeding and were evaluated. Fifty-six control mice received control diet, and 44 survived and were evaluated. Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl] hydrazide appeared to be a strong carcinogenic (21/22) and leukemogenic (19/22) chemical in this animal species. The solid tumors induced included squamous cell and adenocarcinoma of the stomach (21/22), alveolar lung carcinomas (9/22), mammary adenocarcinomas (7/22), and single tumors of the uterus and skin. In the control mice, the following tumor incidences were found: generalized leukemias, 15/44; and lung, 1/44.

AB - Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl] hydrazide was fed to 50 female 5-week-old Swiss mice at a dose of 0.1% by weight of diet for a total of 29 weeks, with a cumulative dose of 1.2 g/mouse/29 weeks. Because of acute toxicity of the chemical and cannibalization by other mice, only 22 of 50 mice survived to the end of feeding and were evaluated. Fifty-six control mice received control diet, and 44 survived and were evaluated. Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl] hydrazide appeared to be a strong carcinogenic (21/22) and leukemogenic (19/22) chemical in this animal species. The solid tumors induced included squamous cell and adenocarcinoma of the stomach (21/22), alveolar lung carcinomas (9/22), mammary adenocarcinomas (7/22), and single tumors of the uterus and skin. In the control mice, the following tumor incidences were found: generalized leukemias, 15/44; and lung, 1/44.

UR - http://www.scopus.com/inward/record.url?scp=0014774525&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0014774525&partnerID=8YFLogxK

M3 - Article

C2 - 4324549

AN - SCOPUS:0014774525

VL - 30

SP - 906

EP - 912

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 4

ER -