Carcinogenicity of Formic Acid 2-[4-(5-Nitro-2-furyl)-2-thiazolyl]-hydrazide in Swiss Mice

S. M. Cohen, E. Ertiirk, George T. Bryan

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Abstract

Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl] hydrazide was fed to 50 female 5-week-old Swiss mice at a dose of 0.1% by weight of diet for a total of 29 weeks, with a cumulative dose of 1.2 g/mouse/29 weeks. Because of acute toxicity of the chemical and cannibalization by other mice, only 22 of 50 mice survived to the end of feeding and were evaluated. Fifty-six control mice received control diet, and 44 survived and were evaluated. Formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl] hydrazide appeared to be a strong carcinogenic (21/22) and leukemogenic (19/22) chemical in this animal species. The solid tumors induced included squamous cell and adenocarcinoma of the stomach (21/22), alveolar lung carcinomas (9/22), mammary adenocarcinomas (7/22), and single tumors of the uterus and skin. In the control mice, the following tumor incidences were found: generalized leukemias, 15/44; and lung, 1/44.

Original languageEnglish (US)
Pages (from-to)906-912
Number of pages7
JournalCancer Research
Volume30
Issue number4
Publication statusPublished - Apr 1970

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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