43 Citations (Scopus)

Abstract

To obtain some initial evidence on the mechanism(s) of activation of PAH in rat mammary gland, we studied the carcinogenicity of a series of PAH directly applied to this tissue. A series of PAH which are or are not expected to be activated by one-electron oxidation because of their low or high ionization potential (IP), respectively, were tested. The compounds were dispersed as fine powders on an exposed mammary gland of female Sprague-Dawley rats. 5-Methylchrysene, dibenz[a,h]anthracene and benz[a]anthracene, which have relatively high IP, were inactive. In contrast, three PAH with relatively low IP, 7,12-dimethylbenz[a]anthracene, benzo[a]pyrene (BP), and 3-methylcholanthrene (MC), were potent carcinogens. 6-MethylBP, with low IP, and 7-methylbenz[a]anthracene, with borderline IP, elicited only mesenchymal tumors, whereas BP 7,8-dihydrodiol and cyclopenta[cd]pyrene were inactive. A series of MC derivatives substituted at C-1 or C-2 was tested. Substituents at C-1, the position of activation in the one-electron oxidation pathway, generally suppressed carcinogenic activity. Substitution at C-2 did not eliminate carcinogenic activity, w9th the exception of MC-2-one. These results provide initial information suggesting that one-electron oxidation may be a mechanism of activation for PAH in the mammary gland.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalJournal of Cancer Research and Clinical Oncology
Volume114
Issue number1
DOIs
StatePublished - Feb 1 1988

Fingerprint

Aromatic Hydrocarbons
Methylcholanthrene
Human Mammary Glands
Electrons
Benzo(a)pyrene
Carcinogens
Powders
Sprague Dawley Rats
Neoplasms

Keywords

  • Carcinogenicity
  • Polycyclic aromatic hydrocarbons
  • Rat mammary gland

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Carcinogenicity of aromatic hydrocarbons directly applied to rat mammary gland. / Cavalieri, Ercole; Rogan, Eleanor G; Sinha, Dilip.

In: Journal of Cancer Research and Clinical Oncology, Vol. 114, No. 1, 01.02.1988, p. 3-9.

Research output: Contribution to journalArticle

@article{d0dad7ef449344ac9898dbb72a6393d3,
title = "Carcinogenicity of aromatic hydrocarbons directly applied to rat mammary gland",
abstract = "To obtain some initial evidence on the mechanism(s) of activation of PAH in rat mammary gland, we studied the carcinogenicity of a series of PAH directly applied to this tissue. A series of PAH which are or are not expected to be activated by one-electron oxidation because of their low or high ionization potential (IP), respectively, were tested. The compounds were dispersed as fine powders on an exposed mammary gland of female Sprague-Dawley rats. 5-Methylchrysene, dibenz[a,h]anthracene and benz[a]anthracene, which have relatively high IP, were inactive. In contrast, three PAH with relatively low IP, 7,12-dimethylbenz[a]anthracene, benzo[a]pyrene (BP), and 3-methylcholanthrene (MC), were potent carcinogens. 6-MethylBP, with low IP, and 7-methylbenz[a]anthracene, with borderline IP, elicited only mesenchymal tumors, whereas BP 7,8-dihydrodiol and cyclopenta[cd]pyrene were inactive. A series of MC derivatives substituted at C-1 or C-2 was tested. Substituents at C-1, the position of activation in the one-electron oxidation pathway, generally suppressed carcinogenic activity. Substitution at C-2 did not eliminate carcinogenic activity, w9th the exception of MC-2-one. These results provide initial information suggesting that one-electron oxidation may be a mechanism of activation for PAH in the mammary gland.",
keywords = "Carcinogenicity, Polycyclic aromatic hydrocarbons, Rat mammary gland",
author = "Ercole Cavalieri and Rogan, {Eleanor G} and Dilip Sinha",
year = "1988",
month = "2",
day = "1",
doi = "10.1007/BF00390478",
language = "English (US)",
volume = "114",
pages = "3--9",
journal = "Zeitschrift fur Krebsforschung und Klinische Onkologie",
issn = "0171-5216",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Carcinogenicity of aromatic hydrocarbons directly applied to rat mammary gland

AU - Cavalieri, Ercole

AU - Rogan, Eleanor G

AU - Sinha, Dilip

PY - 1988/2/1

Y1 - 1988/2/1

N2 - To obtain some initial evidence on the mechanism(s) of activation of PAH in rat mammary gland, we studied the carcinogenicity of a series of PAH directly applied to this tissue. A series of PAH which are or are not expected to be activated by one-electron oxidation because of their low or high ionization potential (IP), respectively, were tested. The compounds were dispersed as fine powders on an exposed mammary gland of female Sprague-Dawley rats. 5-Methylchrysene, dibenz[a,h]anthracene and benz[a]anthracene, which have relatively high IP, were inactive. In contrast, three PAH with relatively low IP, 7,12-dimethylbenz[a]anthracene, benzo[a]pyrene (BP), and 3-methylcholanthrene (MC), were potent carcinogens. 6-MethylBP, with low IP, and 7-methylbenz[a]anthracene, with borderline IP, elicited only mesenchymal tumors, whereas BP 7,8-dihydrodiol and cyclopenta[cd]pyrene were inactive. A series of MC derivatives substituted at C-1 or C-2 was tested. Substituents at C-1, the position of activation in the one-electron oxidation pathway, generally suppressed carcinogenic activity. Substitution at C-2 did not eliminate carcinogenic activity, w9th the exception of MC-2-one. These results provide initial information suggesting that one-electron oxidation may be a mechanism of activation for PAH in the mammary gland.

AB - To obtain some initial evidence on the mechanism(s) of activation of PAH in rat mammary gland, we studied the carcinogenicity of a series of PAH directly applied to this tissue. A series of PAH which are or are not expected to be activated by one-electron oxidation because of their low or high ionization potential (IP), respectively, were tested. The compounds were dispersed as fine powders on an exposed mammary gland of female Sprague-Dawley rats. 5-Methylchrysene, dibenz[a,h]anthracene and benz[a]anthracene, which have relatively high IP, were inactive. In contrast, three PAH with relatively low IP, 7,12-dimethylbenz[a]anthracene, benzo[a]pyrene (BP), and 3-methylcholanthrene (MC), were potent carcinogens. 6-MethylBP, with low IP, and 7-methylbenz[a]anthracene, with borderline IP, elicited only mesenchymal tumors, whereas BP 7,8-dihydrodiol and cyclopenta[cd]pyrene were inactive. A series of MC derivatives substituted at C-1 or C-2 was tested. Substituents at C-1, the position of activation in the one-electron oxidation pathway, generally suppressed carcinogenic activity. Substitution at C-2 did not eliminate carcinogenic activity, w9th the exception of MC-2-one. These results provide initial information suggesting that one-electron oxidation may be a mechanism of activation for PAH in the mammary gland.

KW - Carcinogenicity

KW - Polycyclic aromatic hydrocarbons

KW - Rat mammary gland

UR - http://www.scopus.com/inward/record.url?scp=0023868484&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023868484&partnerID=8YFLogxK

U2 - 10.1007/BF00390478

DO - 10.1007/BF00390478

M3 - Article

C2 - 3350839

AN - SCOPUS:0023868484

VL - 114

SP - 3

EP - 9

JO - Zeitschrift fur Krebsforschung und Klinische Onkologie

JF - Zeitschrift fur Krebsforschung und Klinische Onkologie

SN - 0171-5216

IS - 1

ER -