Carcinogenicity of analgesics: Long‐term treatment of sprague‐dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen)

Sonny L. Johansson

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Six groups of male Sprague‐Dawley rats were treated with phenacetin, phenazone or caffeine in the diet or with combinations of these chemicals. Another group received paracetamol in the diet and a further group received only the control diet. The rats were treated for up to 117 weeks. Renal pelvic tumors were only seen in rats treated with phenacetin or phenazone alone or in combination with caffeine, phenazone having slightly greater activity toward the urinary tract than phenacetin. Phenacetin, however, had a greater overall carcinogenic effect, inducing 31 malignant tumors. The urinary tract and the kidneys had the highest incidence of tumor followed by squamous‐cell carcinomas of the head and neck. Half of the rats treated with phenacetin, phenazone and caffeine in combination developed hepatomas. The explanation may be that the addition of phenazone and caffeine altered the metabolism of phenacetin, increasing the production of N‐hydroxy‐phenacetin, a known liver carcinogen. The justification of using phenacetin as a human analgesic must be seriously questioned, and further studies with phenazone are required.

Original languageEnglish (US)
Pages (from-to)521-529
Number of pages9
JournalInternational Journal of Cancer
Volume27
Issue number4
DOIs
StatePublished - Apr 15 1981

Fingerprint

Phenacetin
Antipyrine
Acetaminophen
Caffeine
Analgesics
Diet
Urinary Tract
Kidney
Neoplasms
Carcinogens
Hepatocellular Carcinoma
Neck
Head
Carcinoma
Liver
Incidence

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Carcinogenicity of analgesics : Long‐term treatment of sprague‐dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen). / Johansson, Sonny L.

In: International Journal of Cancer, Vol. 27, No. 4, 15.04.1981, p. 521-529.

Research output: Contribution to journalArticle

@article{0b11c53ac20544b08ce7fc5cb9daf5b4,
title = "Carcinogenicity of analgesics: Long‐term treatment of sprague‐dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen)",
abstract = "Six groups of male Sprague‐Dawley rats were treated with phenacetin, phenazone or caffeine in the diet or with combinations of these chemicals. Another group received paracetamol in the diet and a further group received only the control diet. The rats were treated for up to 117 weeks. Renal pelvic tumors were only seen in rats treated with phenacetin or phenazone alone or in combination with caffeine, phenazone having slightly greater activity toward the urinary tract than phenacetin. Phenacetin, however, had a greater overall carcinogenic effect, inducing 31 malignant tumors. The urinary tract and the kidneys had the highest incidence of tumor followed by squamous‐cell carcinomas of the head and neck. Half of the rats treated with phenacetin, phenazone and caffeine in combination developed hepatomas. The explanation may be that the addition of phenazone and caffeine altered the metabolism of phenacetin, increasing the production of N‐hydroxy‐phenacetin, a known liver carcinogen. The justification of using phenacetin as a human analgesic must be seriously questioned, and further studies with phenazone are required.",
author = "Johansson, {Sonny L.}",
year = "1981",
month = "4",
day = "15",
doi = "10.1002/ijc.2910270416",
language = "English (US)",
volume = "27",
pages = "521--529",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Carcinogenicity of analgesics

T2 - Long‐term treatment of sprague‐dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen)

AU - Johansson, Sonny L.

PY - 1981/4/15

Y1 - 1981/4/15

N2 - Six groups of male Sprague‐Dawley rats were treated with phenacetin, phenazone or caffeine in the diet or with combinations of these chemicals. Another group received paracetamol in the diet and a further group received only the control diet. The rats were treated for up to 117 weeks. Renal pelvic tumors were only seen in rats treated with phenacetin or phenazone alone or in combination with caffeine, phenazone having slightly greater activity toward the urinary tract than phenacetin. Phenacetin, however, had a greater overall carcinogenic effect, inducing 31 malignant tumors. The urinary tract and the kidneys had the highest incidence of tumor followed by squamous‐cell carcinomas of the head and neck. Half of the rats treated with phenacetin, phenazone and caffeine in combination developed hepatomas. The explanation may be that the addition of phenazone and caffeine altered the metabolism of phenacetin, increasing the production of N‐hydroxy‐phenacetin, a known liver carcinogen. The justification of using phenacetin as a human analgesic must be seriously questioned, and further studies with phenazone are required.

AB - Six groups of male Sprague‐Dawley rats were treated with phenacetin, phenazone or caffeine in the diet or with combinations of these chemicals. Another group received paracetamol in the diet and a further group received only the control diet. The rats were treated for up to 117 weeks. Renal pelvic tumors were only seen in rats treated with phenacetin or phenazone alone or in combination with caffeine, phenazone having slightly greater activity toward the urinary tract than phenacetin. Phenacetin, however, had a greater overall carcinogenic effect, inducing 31 malignant tumors. The urinary tract and the kidneys had the highest incidence of tumor followed by squamous‐cell carcinomas of the head and neck. Half of the rats treated with phenacetin, phenazone and caffeine in combination developed hepatomas. The explanation may be that the addition of phenazone and caffeine altered the metabolism of phenacetin, increasing the production of N‐hydroxy‐phenacetin, a known liver carcinogen. The justification of using phenacetin as a human analgesic must be seriously questioned, and further studies with phenazone are required.

UR - http://www.scopus.com/inward/record.url?scp=0019422232&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019422232&partnerID=8YFLogxK

U2 - 10.1002/ijc.2910270416

DO - 10.1002/ijc.2910270416

M3 - Article

C2 - 7275356

AN - SCOPUS:0019422232

VL - 27

SP - 521

EP - 529

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 4

ER -