Carcinogenicity of 5 nitrofurans and related compounds with amino heterocyclic substituents

Samuel Monroe Cohen, E. Erturk, A. M. von Esch, A. Corvetti, G. Bryan

Research output: Contribution to journalArticle

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Abstract

Carcinogenicity of eight 5 nitrofurans with heterocyclic substituents at the 2 position of the furan ring was investigated by feeding the chemicals to Sprague Dawley female rats. N [5 (5 nitro 2 furyl) 1,3,4 thiadiazol 2 yl]acetamide induced in 30 rats the highest incidence of tumors with the greatest number of tissues involved: forestomach squamous cell tumors (22), kidney pelvis transitional cell carcinomas (15), pulmonary alveolar cell carcinomas (16), hemangioendothelialsarcomas (20) of the intestine, mesentery, liver, lung, and pancreas, and a few tumors of other tissues. 2 Amino 5 (5 nitro 2 furyl) 1,3,4 thiadiazole, 2 amino 5 (5 nitro 2 furyl) 1,3,4 oxadiazole, and trans 2 [(dimethylamino)methylimino] 5 [2 (5 nitro 2 furyl)vinyl] 1,3,4 oxadiazole produced high incidences of mammary tumors. The other four 5 nitrofurans tested: N [4 (5 nitro 2 furyl) 2 thiazolyl]acetamide; 2,2,2 trifluoro N [4 (5 nitro 2 furyl) 2 thiazolyl]acetamide; 5 (5 nitro 2 furyl) 1,3,4 oxadiazol 2 ol; and N {[3 (5 nitro 2 furyl) 1,2,4 oxadiazol 5 yl]methyl}acetamide were associated with tumor incidences of 40 to 60%. Two other chemicals were also tested: 2 Amino 5 nitrothiazole caused a low incidence of breast and kidney pelvis tumors, and 2 amino 4 (p nitrophenyl)thiazole induced a high incidence of breast and salivary gland adenocarcinomas and lymphomas.

Original languageEnglish (US)
Pages (from-to)841-850
Number of pages10
JournalJournal of the National Cancer Institute
Volume54
Issue number4
StatePublished - Dec 1 1975

Fingerprint

Nitrofurans
Incidence
Kidney Pelvis
2-amino-1,3,4-thiadiazole
Neoplasms
Breast
Bronchiolo-Alveolar Adenocarcinoma
Thiazoles
Lung
Mesentery
Transitional Cell Carcinoma
Salivary Glands
Intestines
Sprague Dawley Rats
Pancreas
Lymphoma
Adenocarcinoma
Epithelial Cells
Breast Neoplasms
Liver

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Carcinogenicity of 5 nitrofurans and related compounds with amino heterocyclic substituents. / Cohen, Samuel Monroe; Erturk, E.; von Esch, A. M.; Corvetti, A.; Bryan, G.

In: Journal of the National Cancer Institute, Vol. 54, No. 4, 01.12.1975, p. 841-850.

Research output: Contribution to journalArticle

Cohen, Samuel Monroe ; Erturk, E. ; von Esch, A. M. ; Corvetti, A. ; Bryan, G. / Carcinogenicity of 5 nitrofurans and related compounds with amino heterocyclic substituents. In: Journal of the National Cancer Institute. 1975 ; Vol. 54, No. 4. pp. 841-850.
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abstract = "Carcinogenicity of eight 5 nitrofurans with heterocyclic substituents at the 2 position of the furan ring was investigated by feeding the chemicals to Sprague Dawley female rats. N [5 (5 nitro 2 furyl) 1,3,4 thiadiazol 2 yl]acetamide induced in 30 rats the highest incidence of tumors with the greatest number of tissues involved: forestomach squamous cell tumors (22), kidney pelvis transitional cell carcinomas (15), pulmonary alveolar cell carcinomas (16), hemangioendothelialsarcomas (20) of the intestine, mesentery, liver, lung, and pancreas, and a few tumors of other tissues. 2 Amino 5 (5 nitro 2 furyl) 1,3,4 thiadiazole, 2 amino 5 (5 nitro 2 furyl) 1,3,4 oxadiazole, and trans 2 [(dimethylamino)methylimino] 5 [2 (5 nitro 2 furyl)vinyl] 1,3,4 oxadiazole produced high incidences of mammary tumors. The other four 5 nitrofurans tested: N [4 (5 nitro 2 furyl) 2 thiazolyl]acetamide; 2,2,2 trifluoro N [4 (5 nitro 2 furyl) 2 thiazolyl]acetamide; 5 (5 nitro 2 furyl) 1,3,4 oxadiazol 2 ol; and N {[3 (5 nitro 2 furyl) 1,2,4 oxadiazol 5 yl]methyl}acetamide were associated with tumor incidences of 40 to 60{\%}. Two other chemicals were also tested: 2 Amino 5 nitrothiazole caused a low incidence of breast and kidney pelvis tumors, and 2 amino 4 (p nitrophenyl)thiazole induced a high incidence of breast and salivary gland adenocarcinomas and lymphomas.",
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N2 - Carcinogenicity of eight 5 nitrofurans with heterocyclic substituents at the 2 position of the furan ring was investigated by feeding the chemicals to Sprague Dawley female rats. N [5 (5 nitro 2 furyl) 1,3,4 thiadiazol 2 yl]acetamide induced in 30 rats the highest incidence of tumors with the greatest number of tissues involved: forestomach squamous cell tumors (22), kidney pelvis transitional cell carcinomas (15), pulmonary alveolar cell carcinomas (16), hemangioendothelialsarcomas (20) of the intestine, mesentery, liver, lung, and pancreas, and a few tumors of other tissues. 2 Amino 5 (5 nitro 2 furyl) 1,3,4 thiadiazole, 2 amino 5 (5 nitro 2 furyl) 1,3,4 oxadiazole, and trans 2 [(dimethylamino)methylimino] 5 [2 (5 nitro 2 furyl)vinyl] 1,3,4 oxadiazole produced high incidences of mammary tumors. The other four 5 nitrofurans tested: N [4 (5 nitro 2 furyl) 2 thiazolyl]acetamide; 2,2,2 trifluoro N [4 (5 nitro 2 furyl) 2 thiazolyl]acetamide; 5 (5 nitro 2 furyl) 1,3,4 oxadiazol 2 ol; and N {[3 (5 nitro 2 furyl) 1,2,4 oxadiazol 5 yl]methyl}acetamide were associated with tumor incidences of 40 to 60%. Two other chemicals were also tested: 2 Amino 5 nitrothiazole caused a low incidence of breast and kidney pelvis tumors, and 2 amino 4 (p nitrophenyl)thiazole induced a high incidence of breast and salivary gland adenocarcinomas and lymphomas.

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