Carcinogenicity of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2) fed to female Sprague-Dawley rats

S. M. Cohen, M. Ichikawa, G. T. Bryan

Research output: Contribution to journalArticle

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Abstract

The carcinogenicity of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2) was investigated by administering it orally to Sprague-Dawley female weanling rats in a grain diet as a dose of 0.2% for 46 weeks, followed by 20 weeks of unmedicated control diet. The total mean cumulative dose of AF-2 was 10.1 g (41.6 mmol) per rat during the 46 weeks of the experiment. Weight gain of rats fed AF-2 was comparable to that of unmedicated control rats. Survival of rats fed AF-2 was 52±12 (SD) weeks compared to 65±5 weeks for the unmedicated controls (P<0.001). Twenty-four of 29 rats fed AF-2 developed multiple breast tumors, 15 of which were adenocarcinomas. Two of 29 unmedicated controls rats had single fibroadenomas of the breast.

Original languageEnglish (US)
Pages (from-to)473-476
Number of pages4
JournalGann, The Japanese Journal of Cancer Research
Volume68
Issue number4
StatePublished - Dec 1 1977

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Furylfuramide
Acrylamide
Sprague Dawley Rats
Diet
Fibroadenoma
Weight Gain
Adenocarcinoma
Breast
Breast Neoplasms

ASJC Scopus subject areas

  • Cancer Research

Cite this

Carcinogenicity of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2) fed to female Sprague-Dawley rats. / Cohen, S. M.; Ichikawa, M.; Bryan, G. T.

In: Gann, The Japanese Journal of Cancer Research, Vol. 68, No. 4, 01.12.1977, p. 473-476.

Research output: Contribution to journalArticle

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abstract = "The carcinogenicity of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2) was investigated by administering it orally to Sprague-Dawley female weanling rats in a grain diet as a dose of 0.2{\%} for 46 weeks, followed by 20 weeks of unmedicated control diet. The total mean cumulative dose of AF-2 was 10.1 g (41.6 mmol) per rat during the 46 weeks of the experiment. Weight gain of rats fed AF-2 was comparable to that of unmedicated control rats. Survival of rats fed AF-2 was 52±12 (SD) weeks compared to 65±5 weeks for the unmedicated controls (P<0.001). Twenty-four of 29 rats fed AF-2 developed multiple breast tumors, 15 of which were adenocarcinomas. Two of 29 unmedicated controls rats had single fibroadenomas of the breast.",
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