Candida albicans quorum sensing molecules stimulate mouse macrophage migration

Jessica C. Hargarten, Tyler C. Moore, Thomas M Petro, Kenneth Nickerson, Audrey L Atkin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The polymorphic commensal fungus Candida albicans causes life-threatening disease via bloodstream and intra-abdominal infections in immunocompromised and transplant patients. Although host immune evasion is a common strategy used by successful human fungal pathogens, C. albicans provokes recognition by host immune cells less capable of destroying it. To accomplish this, C. albicans white cells secrete a low-molecular-weight chemoattractive stimulant(s) of macrophages, a phagocyte that they are able to survive within and eventually escape from. C. albicans opaque cells do not secrete this chemoattractive stimulant(s). We report here a physiological mechanism that contributes to the differences in the interaction of C. albicans white and opaque cells with macrophages. E, E-Farnesol, which is secreted by white cells only, is a potent stimulator of macrophage chemokinesis, whose activity is enhanced by yeast cell wall components and aromatic alcohols. E, E-farnesol results in up to an 8.5-fold increase in macrophage migration in vitro and promotes a 3-fold increase in the peritoneal infiltration of macrophages in vivo. Therefore, modulation of farnesol secretion to stimulate host immune recognition by macrophages may help explain why this commensal is such a successful pathogen.

Original languageEnglish (US)
Pages (from-to)3857-3864
Number of pages8
JournalInfection and immunity
Volume83
Issue number10
DOIs
StatePublished - Jan 1 2015

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Quorum Sensing
Candida albicans
Farnesol
Macrophages
Intraabdominal Infections
Immune Evasion
Immunocompromised Host
Peritoneal Macrophages
Cellular Structures
Phagocytes
Cell Wall
Fungi
Yeasts
Molecular Weight
Alcohols
Transplants

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Candida albicans quorum sensing molecules stimulate mouse macrophage migration. / Hargarten, Jessica C.; Moore, Tyler C.; Petro, Thomas M; Nickerson, Kenneth; Atkin, Audrey L.

In: Infection and immunity, Vol. 83, No. 10, 01.01.2015, p. 3857-3864.

Research output: Contribution to journalArticle

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