Cancer stem cells and colorectal cancer

An overview

Punita Dhawan, Rizwan Ahmad, Anand S. Srivastava, Amar Bahadur Singh

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

Normal tissue homeostasis involves a careful balance between the normal cell loss and renewal. Stem and progenitor cells help maintain this precise and fine balance through their ability of self-renewal in a tightly regulated manner. In this regard, the gastrointestinal epithelium is unique in that cell proliferation, differentiation, and apoptosis occur in an orderly fashion along the crypt-villus axis. The colonic crypt is primarily a proliferative compartment, is monoclonal and is maintained by stem cells. The concept of tissue stem cells capable of giving rise to all differentiated cells within a given tissue has led to the concept of a cellular hierarchy in tissues and in tumors including colorectal cancer (CRC). Thus, only a few cells may be necessary and sufficient for tissue repair or tumor regeneration. However, such a proposition also raises questions regarding the precise methods and markers to identify such population and to define the circumstantial evidences and place for the origin and establishment of the early mutant stem-cell population. Thus, it is imperative that we understand what cancer stem cells (CSC) are and their potential association with cancer in a tissue specific manner. In this review, we have summarized the current knowledge of stem cell organization and CSC within the colonic epithelium and discussed the potential role of CSC in the development and/or progression of CRC and as targets for therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)1592-1598
Number of pages7
JournalCurrent Topics in Medicinal Chemistry
Volume11
Issue number13
DOIs
StatePublished - Jul 1 2011

Fingerprint

Neoplastic Stem Cells
Colorectal Neoplasms
Stem Cells
Epithelium
Neoplasms
Population
Regeneration
Cell Differentiation
Homeostasis
Cell Proliferation
Apoptosis

Keywords

  • Cancer stem cell
  • Colon cancer
  • Colonic crypt
  • Pluripotent
  • Wnt signaling

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Cancer stem cells and colorectal cancer : An overview. / Dhawan, Punita; Ahmad, Rizwan; Srivastava, Anand S.; Singh, Amar Bahadur.

In: Current Topics in Medicinal Chemistry, Vol. 11, No. 13, 01.07.2011, p. 1592-1598.

Research output: Contribution to journalReview article

Dhawan, Punita ; Ahmad, Rizwan ; Srivastava, Anand S. ; Singh, Amar Bahadur. / Cancer stem cells and colorectal cancer : An overview. In: Current Topics in Medicinal Chemistry. 2011 ; Vol. 11, No. 13. pp. 1592-1598.
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