Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human LDH-a, skeletal muscle isoenzyme

Steven S.L. Li, Yu Ching E. Pan, Farida S. Sharief, Mary Jo Evans, Ming-Fong Lin, Gail M. Clinton, J. John Holbrook

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human skeletal muscle isoenzyme, since the partial amino acid sequences of human liver LDH-K/A protein were found to be identical with the known primary structure of human LDH-A isoenzyme and the LDH-A isoenzymes from human placenta and bovine muscle were shown to be tyrosylphosphorylated. This tyrosylphosphorylated LDH-K/A protein was also found to be complexed with 21 kD, 30 kD, and 56 kD proteins.

Original languageEnglish (US)
Pages (from-to)93-101
Number of pages9
JournalCancer Investigation
Volume6
Issue number1
DOIs
StatePublished - Jan 1 1988

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L-Lactate Dehydrogenase
Isoenzymes
Skeletal Muscle
Neoplasms
Proteins
Placenta
Amino Acid Sequence
Muscles
Liver
lactate dehydrogenase 5
lactate dehydrogenase-K

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human LDH-a, skeletal muscle isoenzyme. / Li, Steven S.L.; Pan, Yu Ching E.; Sharief, Farida S.; Jo Evans, Mary; Lin, Ming-Fong; Clinton, Gail M.; Holbrook, J. John.

In: Cancer Investigation, Vol. 6, No. 1, 01.01.1988, p. 93-101.

Research output: Contribution to journalArticle

Li, Steven S.L. ; Pan, Yu Ching E. ; Sharief, Farida S. ; Jo Evans, Mary ; Lin, Ming-Fong ; Clinton, Gail M. ; Holbrook, J. John. / Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human LDH-a, skeletal muscle isoenzyme. In: Cancer Investigation. 1988 ; Vol. 6, No. 1. pp. 93-101.
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