Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human LDH-a, skeletal muscle isoenzyme

Steven S.L. Li, Yu Ching E. Pan, Farida S. Sharief, Mary Jo Evans, Ming Fong Lin, Gail M. Clinton, J. John Holbrook

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Abstract

Cancer-associated lactate dehydrogenase is a tyrosylphosphorylated form of human skeletal muscle isoenzyme, since the partial amino acid sequences of human liver LDH-K/A protein were found to be identical with the known primary structure of human LDH-A isoenzyme and the LDH-A isoenzymes from human placenta and bovine muscle were shown to be tyrosylphosphorylated. This tyrosylphosphorylated LDH-K/A protein was also found to be complexed with 21 kD, 30 kD, and 56 kD proteins.

Original languageEnglish (US)
Pages (from-to)93-101
Number of pages9
JournalCancer Investigation
Volume6
Issue number1
DOIs
Publication statusPublished - Jan 1 1988

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ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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