Can recombinant DNA technology provide useful vaccines against viruses which induce heart disease?

Nora M Chapman, Steven M Tracy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the panoply of armaments against viral infections, both drugs and vaccines have been employed. Numerous vaccines have enjoyed spectacular success in either eradicating or controlling various viral diseases, whereas there are still few, effective anti-viral drugs. Coxsackie B viruses are agents of human inflammatory heart disease and may trigger events lending to a failing heart. We believe that enteroviral heart disease could be controlled or eradicated through the use of vaccines, in much the same manner as poliovirus-induced poliomyelitis has been controlled through vaccination. We present here preliminary data which deal with an approach to the development of enterovirus vaccines and the use of a chimeric coxsackievirus us B3 (CVB3) vaccine in a murine model of CVB3-induced inflammatory heart disease.

Original languageEnglish (US)
Pages (from-to)144-146
Number of pages3
JournalEuropean Heart Journal
Volume16
Issue numberSUPPL. O
StatePublished - Dec 1 1995

Fingerprint

Recombinant DNA
Heart Diseases
Vaccines
Enterovirus
Viruses
Technology
Virus Diseases
Human Enterovirus B
Poliovirus
Poliomyelitis
Pharmaceutical Preparations
Vaccination

Keywords

  • Coxsackievirus B3
  • Enterovirus
  • Vaccines

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Can recombinant DNA technology provide useful vaccines against viruses which induce heart disease? / Chapman, Nora M; Tracy, Steven M.

In: European Heart Journal, Vol. 16, No. SUPPL. O, 01.12.1995, p. 144-146.

Research output: Contribution to journalArticle

Chapman, Nora M ; Tracy, Steven M. / Can recombinant DNA technology provide useful vaccines against viruses which induce heart disease?. In: European Heart Journal. 1995 ; Vol. 16, No. SUPPL. O. pp. 144-146.
@article{2f967d591b29470bb12b18ef1375c56c,
title = "Can recombinant DNA technology provide useful vaccines against viruses which induce heart disease?",
abstract = "In the panoply of armaments against viral infections, both drugs and vaccines have been employed. Numerous vaccines have enjoyed spectacular success in either eradicating or controlling various viral diseases, whereas there are still few, effective anti-viral drugs. Coxsackie B viruses are agents of human inflammatory heart disease and may trigger events lending to a failing heart. We believe that enteroviral heart disease could be controlled or eradicated through the use of vaccines, in much the same manner as poliovirus-induced poliomyelitis has been controlled through vaccination. We present here preliminary data which deal with an approach to the development of enterovirus vaccines and the use of a chimeric coxsackievirus us B3 (CVB3) vaccine in a murine model of CVB3-induced inflammatory heart disease.",
keywords = "Coxsackievirus B3, Enterovirus, Vaccines",
author = "Chapman, {Nora M} and Tracy, {Steven M}",
year = "1995",
month = "12",
day = "1",
language = "English (US)",
volume = "16",
pages = "144--146",
journal = "European Heart Journal",
issn = "0195-668X",
publisher = "Oxford University Press",
number = "SUPPL. O",

}

TY - JOUR

T1 - Can recombinant DNA technology provide useful vaccines against viruses which induce heart disease?

AU - Chapman, Nora M

AU - Tracy, Steven M

PY - 1995/12/1

Y1 - 1995/12/1

N2 - In the panoply of armaments against viral infections, both drugs and vaccines have been employed. Numerous vaccines have enjoyed spectacular success in either eradicating or controlling various viral diseases, whereas there are still few, effective anti-viral drugs. Coxsackie B viruses are agents of human inflammatory heart disease and may trigger events lending to a failing heart. We believe that enteroviral heart disease could be controlled or eradicated through the use of vaccines, in much the same manner as poliovirus-induced poliomyelitis has been controlled through vaccination. We present here preliminary data which deal with an approach to the development of enterovirus vaccines and the use of a chimeric coxsackievirus us B3 (CVB3) vaccine in a murine model of CVB3-induced inflammatory heart disease.

AB - In the panoply of armaments against viral infections, both drugs and vaccines have been employed. Numerous vaccines have enjoyed spectacular success in either eradicating or controlling various viral diseases, whereas there are still few, effective anti-viral drugs. Coxsackie B viruses are agents of human inflammatory heart disease and may trigger events lending to a failing heart. We believe that enteroviral heart disease could be controlled or eradicated through the use of vaccines, in much the same manner as poliovirus-induced poliomyelitis has been controlled through vaccination. We present here preliminary data which deal with an approach to the development of enterovirus vaccines and the use of a chimeric coxsackievirus us B3 (CVB3) vaccine in a murine model of CVB3-induced inflammatory heart disease.

KW - Coxsackievirus B3

KW - Enterovirus

KW - Vaccines

UR - http://www.scopus.com/inward/record.url?scp=0029554569&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029554569&partnerID=8YFLogxK

M3 - Article

VL - 16

SP - 144

EP - 146

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - SUPPL. O

ER -