Can increased understanding of the role of lung development and aging drive new advances in chronic obstructive pulmonary disease?

Rose A. Maciewicz, David Warburton, Stephen I. Rennard

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To advance our ability to effect earlier diagnosis, prevent, and possibly restore healthy lung function in patients with chronic obstructive pulmonary disease (COPD) may require novel thinking. Oneavenueto explore is the concept ofCOPDas a trans-generational disease. Early development and COPD may be related first by failure of normal growth development leading to an increased risk of disease, and second by recapitulation of some developmental pathways that may be key to lung repair after injury. While we should be mindful that "aging" may not be only thought of as "late" development in a COPD context, the aging process in the lung is probably fundamentally different from emphysema. However, injury of the aging lung may result in emphysema. Finally, taking a more holistic view of COPD, aging and development in extrapulmonary contexts (e.g., musculoskeletal or immune systems) may also impact on COPD initiation and progression. Addressing the impact of development and the aging process on the natural history of the disease, both in men and in women, may open up research avenues that will drive new advances in disease classification, diagnosis, prognosis, and therapy for this chronic debilitating lung disease.

Original languageEnglish (US)
Pages (from-to)614-617
Number of pages4
JournalProceedings of the American Thoracic Society
Volume6
Issue number7
DOIs
StatePublished - Dec 1 2009

Fingerprint

Chronic Obstructive Pulmonary Disease
Lung
Emphysema
Musculoskeletal System
Lung Injury
Growth and Development
Lung Diseases
Disease Progression
Early Diagnosis
Immune System
Wounds and Injuries
Research
Therapeutics

Keywords

  • Aging
  • Chronic obstructive pulmonary disease
  • Lung development
  • Respiratory disease

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Can increased understanding of the role of lung development and aging drive new advances in chronic obstructive pulmonary disease? / Maciewicz, Rose A.; Warburton, David; Rennard, Stephen I.

In: Proceedings of the American Thoracic Society, Vol. 6, No. 7, 01.12.2009, p. 614-617.

Research output: Contribution to journalArticle

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