Calcium intake and prostate cancer among African Americans: Effect modification by vitamin D receptor calcium absorption genotype

Glovioell W. Rowland, Gary G. Schwartz, Esther M. John, Sue Ann Ingles

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

High dietary intake of calcium has been classified as a probable cause of prostate cancer, although the mechanism underlying the association between dietary calcium and prostate cancer risk is unclear. The vitamin D receptor (VDR) is a key regulator of calcium absorption. In the small intestine, VDR expression is regulated by the CDX-2 transcription factor, which binds a polymorphic site in the VDR gene promoter. We examined VDR Cdx2 genotype and calcium intake, assessed by a food frequency questionnaire, in 533 African-American prostate cancer cases (256 with advanced stage at diagnosis, 277 with localized stage) and 250 African-American controls who participated in the California Collaborative Prostate Cancer Study. We examined the effects of genotype, calcium intake, and diet-gene interactions by conditional logistic regression. Compared with men in the lowest quartile of calcium intake, men in the highest quartile had an approximately twofold increased risk of localized and advanced prostate cancer (odds ratio [OR]=2.20, 95% confidence interval [CI]=1.40, 3.46), with a significant dose-response. Poor absorbers of calcium (VDR Cdx2 GG genotype) had a significantly lower risk of advanced prostate cancer (OR=0.41, 95% CI=0.19, 0.90). The gene-calcium interaction was statistically significant (p=0.03). Among men with calcium intake below the median (680 mg/day), carriers of the G allele had an approximately 50% decreased risk compared with men with the AA genotype. These findings suggest a link between prostate cancer risk and high intestinal absorption of calcium.

Original languageEnglish (US)
Pages (from-to)187-194
Number of pages8
JournalJournal of Bone and Mineral Research
Volume27
Issue number1
DOIs
StatePublished - Jan 1 2012

Fingerprint

Calcitriol Receptors
African Americans
Prostatic Neoplasms
Genotype
Calcium
Dietary Calcium
Odds Ratio
Confidence Intervals
Genes
Intestinal Absorption
Small Intestine
Transcription Factors
Logistic Models
Alleles
Diet
Food

Keywords

  • African-American
  • Calcium absorption
  • Genetic polymorphism
  • Prostate cancer
  • Vitamin D receptor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

Cite this

Calcium intake and prostate cancer among African Americans : Effect modification by vitamin D receptor calcium absorption genotype. / Rowland, Glovioell W.; Schwartz, Gary G.; John, Esther M.; Ingles, Sue Ann.

In: Journal of Bone and Mineral Research, Vol. 27, No. 1, 01.01.2012, p. 187-194.

Research output: Contribution to journalArticle

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