Calcium absorption response to cholecalciferol supplementation in hemodialysis

Laura AG Armas, Mohsen Zena, Richard Lund, Robert P. Heaney

Research output: Contribution to journalArticle

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Abstract

Background and objectives Recent understanding of extrarenal production of calcitriol has led to the use of more vitaminD supplementation in CKD populations. This paper reports the effect of cholecalciferol supplementation on calcium absorption. Design, setting, participants, & measurements Paired calcium absorption tests were done before and after 12-13 weeks of 20,000 IUweekly cholecalciferol supplementation in 30 participants with stage 5 CKD on hemodialysis. The study was conducted from April to December of 2011. Calcium absorption was tested with a standardized meal containing 300 mg calcium carbonate intrinsically labeled with 45Ca; 25-hydroxyvitamin D and 1,25- dihydroxyvitamin D were measured. Results 25-Hydroxyvitamin D rose from 14.2 ng/ml (11.5-18.5) at baseline to 49.3 ng/ml (42.3-58.1) at the end of the study (P<0.001). 1,25-Dihydroxyvitamin D rose from 15.1 (10.5-18.8) pg/ml at baseline to 20.5 (17.0-24.7) pg/ml at the end of the study (P<0.001). The median baseline calcium absorption was 12% 7%-17%) and 12% (7%-16%) at the end of study. Conclusions Patients with stage 5 CKD on hemodialysis had very low calcium absorption values at baseline, and cholecalciferol supplementation that raised 25(OH)D levels to 50 ng/ml had no effect on calcium absorption.

Original languageEnglish (US)
Pages (from-to)1003-1008
Number of pages6
JournalClinical Journal of the American Society of Nephrology
Volume8
Issue number6
DOIs
Publication statusPublished - Jun 7 2013

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ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation

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