Cadherin switching

Margaret J. Wheelock, Yasushi Shintani, Masato Maeda, Yuri Fukumoto, Keith R Johnson

Research output: Contribution to journalComment/debate

485 Citations (Scopus)

Abstract

The cadherin molecules at adherens junctions have multiple isoforms. Cadherin isoform switching (cadherin switching) occurs during normal developmental processes to allow cell types to segregate from one another. Tumor cells often recapitulate this activity and the result is an aggressive tumor cell that gains the ability to leave the site of the tumor and metastasize. At present, we understand some of the mechanisms that promote cadherin switching and some of the pathways downstream of this process that influence cell behavior. Specific cadherin family members influence growth-factor-receptor signaling and Rho GTPases to promote cell motility and invasion. In addition, p120-catenin probably plays multiple roles in cadherin switching, regulating Rho GTPases and stabilizing cadherins.

Original languageEnglish (US)
Pages (from-to)727-735
Number of pages9
JournalJournal of cell science
Volume121
Issue number6
DOIs
StatePublished - Mar 15 2008

Fingerprint

Cadherins
rho GTP-Binding Proteins
Protein Isoforms
Adherens Junctions
Neoplasms
Aptitude
Growth Factor Receptors
Cell Movement

Keywords

  • Biology
  • Cadherin
  • Switching

ASJC Scopus subject areas

  • Cell Biology

Cite this

Wheelock, M. J., Shintani, Y., Maeda, M., Fukumoto, Y., & Johnson, K. R. (2008). Cadherin switching. Journal of cell science, 121(6), 727-735. https://doi.org/10.1242/jcs.000455

Cadherin switching. / Wheelock, Margaret J.; Shintani, Yasushi; Maeda, Masato; Fukumoto, Yuri; Johnson, Keith R.

In: Journal of cell science, Vol. 121, No. 6, 15.03.2008, p. 727-735.

Research output: Contribution to journalComment/debate

Wheelock, MJ, Shintani, Y, Maeda, M, Fukumoto, Y & Johnson, KR 2008, 'Cadherin switching', Journal of cell science, vol. 121, no. 6, pp. 727-735. https://doi.org/10.1242/jcs.000455
Wheelock MJ, Shintani Y, Maeda M, Fukumoto Y, Johnson KR. Cadherin switching. Journal of cell science. 2008 Mar 15;121(6):727-735. https://doi.org/10.1242/jcs.000455
Wheelock, Margaret J. ; Shintani, Yasushi ; Maeda, Masato ; Fukumoto, Yuri ; Johnson, Keith R. / Cadherin switching. In: Journal of cell science. 2008 ; Vol. 121, No. 6. pp. 727-735.
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