Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma

Roger Paul, Charles M. Ewing, John C. Robinson, Fray F. Marshall, Keith R Johnson, Margaret J. Wheelock, William B. Isaacs

Research output: Contribution to journalArticle

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Abstract

Cadherins are a family of calcium-dependent, cell-cell adhesion molecules that play an important morphoregulatory role in a wide variety of tissues. Alterations in cadherin function have been implicated in tumor progression in a number of adenocarcinomas. Despite the increasing number of new cadherins identified, little is known about cadherins in normal renal tissue and renal carcinomas. A novel cadherin transcript, cadherin-6, was recently described to be present in renal cancer cell lines and fetal kidney, but no data on protein expression nor tissue localization has been reported. In this study, we demonstrate that the expression of cadherin-6 is restricted to the proximal tubule epithelium. This finding is critical because these cells give rise to the majority of neoplasms of this organ. Furthermore we demonstrate typical cadherin features of cadherin-6, including cytoplasmic binding to α- and β-catenin. We present data of cadherin-6 expression in a series of 32 primary renal cell cancers. Cadherin-6 expression tended to vary with histology in these samples. Whereas the majority of renal cell cancers with histology-associated poor prognosis (i.e., high grade clear cell carcinomas and sarcomatoid renal tumors) show aberrant expression of cadherin-6, in tumors with a favorable prognosis (i.e., low grade clear cell carcinomas and papillary cancers), normal cadherin-6 expression was predominant. Overall, these findings demonstrate specific expression of cadherin-6 in the proximal renal tubules in normal human kidney and suggest that alterations of cadherin-6 expression are associated with progression or renal cell carcinoma.

Original languageEnglish (US)
Pages (from-to)2741-2748
Number of pages8
JournalCancer Research
Volume57
Issue number13
StatePublished - Jul 1 1997

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Proximal Kidney Tubule
Cell Adhesion Molecules
Renal Cell Carcinoma
Cadherins
Kidney
Neoplasms
Histology
K cadherin
Catenins
Kidney Neoplasms
Papillary Carcinoma
Adenocarcinoma
Epithelium
Calcium
Carcinoma
Cell Line

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Paul, R., Ewing, C. M., Robinson, J. C., Marshall, F. F., Johnson, K. R., Wheelock, M. J., & Isaacs, W. B. (1997). Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma. Cancer Research, 57(13), 2741-2748.

Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma. / Paul, Roger; Ewing, Charles M.; Robinson, John C.; Marshall, Fray F.; Johnson, Keith R; Wheelock, Margaret J.; Isaacs, William B.

In: Cancer Research, Vol. 57, No. 13, 01.07.1997, p. 2741-2748.

Research output: Contribution to journalArticle

Paul, R, Ewing, CM, Robinson, JC, Marshall, FF, Johnson, KR, Wheelock, MJ & Isaacs, WB 1997, 'Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma', Cancer Research, vol. 57, no. 13, pp. 2741-2748.
Paul R, Ewing CM, Robinson JC, Marshall FF, Johnson KR, Wheelock MJ et al. Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma. Cancer Research. 1997 Jul 1;57(13):2741-2748.
Paul, Roger ; Ewing, Charles M. ; Robinson, John C. ; Marshall, Fray F. ; Johnson, Keith R ; Wheelock, Margaret J. ; Isaacs, William B. / Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma. In: Cancer Research. 1997 ; Vol. 57, No. 13. pp. 2741-2748.
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