24 Citations (Scopus)

Abstract

This is a double-blind placebo-controlled study of sustained-release bupropion as a smoking cessation aid in alcoholics undergoing treatment for their alcoholism. Participants (N = 58) were enrolled within 1 week of entry into alcohol treatment from community and Veterans Affairs Substance Use Disorder programs. All participants received nicotine patch and were invited to attend a smoking cessation lecture and group. Cigarette smoking and alcohol outcomes were measured at 6 months. Bupropion when added to nicotine patch did not improve smoking outcomes. One third of participants on bupropion reported discontinuing the drug during weeks 1-4. Participants reported cigarette outcomes with nicotine patch that are similar to those seen in the general population. All study participants significantly reduced cigarette use. Comorbid affective disorder or antipersonality disorder did not affect outcomes. Alcohol outcomes were improved in those who discontinued cigarettes.

Original languageEnglish (US)
Pages (from-to)381-391
Number of pages11
JournalAlcohol
Volume41
Issue number5
DOIs
StatePublished - Aug 1 2007

Fingerprint

Tobacco Use Cessation Products
Bupropion
Smoking Cessation
Alcoholics
alcoholism
Tobacco Products
nicotine
smoking
Alcohols
Smoking
alcohol
Veterans
Mood Disorders
Alcoholism
Substance-Related Disorders
Placebos
Therapeutics
Pharmaceutical Preparations
Population
drug

Keywords

  • Alcoholism
  • Bupropion
  • Nicotine dependence
  • Nicotine replacement
  • Smoking cessation

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

Cite this

Bupropion and nicotine patch as smoking cessation aids in alcoholics. / Grant, Kathleen M; Kelley, Stephanie Sinclair; Smith, Lynette M; Agrawal, Sangeeta; Meyer, James R.; Romberger, Debra.

In: Alcohol, Vol. 41, No. 5, 01.08.2007, p. 381-391.

Research output: Contribution to journalArticle

Grant, Kathleen M ; Kelley, Stephanie Sinclair ; Smith, Lynette M ; Agrawal, Sangeeta ; Meyer, James R. ; Romberger, Debra. / Bupropion and nicotine patch as smoking cessation aids in alcoholics. In: Alcohol. 2007 ; Vol. 41, No. 5. pp. 381-391.
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