Bronchoalveolar lavage in the cytologic diagnosis of carcinoma of the lung

James Linder, Stanley J Radio, R. A. Robbins, M. Ghafouri, S. I. Rennard

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

To assess the utility of bronchoalveolar lavage as a technique for diagnosing lung cancer, 850 lavages from 421 patients were reviewed. Biopsy-proven lung carcinoma was present in 35 cases. Of these, 24 (68.6%) had cells diagnostic of malignancy on cytologic preparations of the bronchoalveolar lavage fluid. Agreement between cancer subtypes determined by lavage and by tissue biopsy was 79.1%; variation usually occurred between large cell undifferentiated carcinoma and adenocarcinoma, not with small cell anaplastic carcinoma. The subtype of tumors was most accurately determined by examination of Papanicolaou-stained slides. Reactive bronchial epithelium often mimicked carcinoma, but could be correctly identified by its characteristic cytomorphology. No false-positive diagnoses of lung cancer occurred in 386 patients. The sensitivity of bronchoalveolar lavage for the diagnosis of lung carcinoma is similar to that of transbronchial biopsy and Wang needle biopsy. Because bronchoalveolar lavage may detect opportunistic infections, interstitial lung diseases and malignant cells with a low morbidity, it is a useful tool to assess patients with pulmonary infiltrates.

Original languageEnglish (US)
Pages (from-to)796-801
Number of pages6
JournalActa Cytologica
Volume31
Issue number6
StatePublished - Dec 1 1987

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Bronchoalveolar Lavage
Carcinoma
Lung
Therapeutic Irrigation
Biopsy
Lung Neoplasms
Large Cell Carcinoma
Neoplasms
Small Cell Carcinoma
Interstitial Lung Diseases
Opportunistic Infections
Bronchoalveolar Lavage Fluid
Needle Biopsy
Adenocarcinoma
Epithelium
Morbidity

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Linder, J., Radio, S. J., Robbins, R. A., Ghafouri, M., & Rennard, S. I. (1987). Bronchoalveolar lavage in the cytologic diagnosis of carcinoma of the lung. Acta Cytologica, 31(6), 796-801.

Bronchoalveolar lavage in the cytologic diagnosis of carcinoma of the lung. / Linder, James; Radio, Stanley J; Robbins, R. A.; Ghafouri, M.; Rennard, S. I.

In: Acta Cytologica, Vol. 31, No. 6, 01.12.1987, p. 796-801.

Research output: Contribution to journalArticle

Linder, J, Radio, SJ, Robbins, RA, Ghafouri, M & Rennard, SI 1987, 'Bronchoalveolar lavage in the cytologic diagnosis of carcinoma of the lung', Acta Cytologica, vol. 31, no. 6, pp. 796-801.
Linder, James ; Radio, Stanley J ; Robbins, R. A. ; Ghafouri, M. ; Rennard, S. I. / Bronchoalveolar lavage in the cytologic diagnosis of carcinoma of the lung. In: Acta Cytologica. 1987 ; Vol. 31, No. 6. pp. 796-801.
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