Broadband neurophysiological abnormalities in the medial prefrontal region of the default-mode network in adults with ADHD

Tony W Wilson, John D. Franzen, Elizabeth C Heinrichs-Graham, Matthew L White, Nichole L. Knott, Martin W. Wetzel

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Previous investigations of the default-mode network (DMN) in persons with attention-deficit/hyperactivity disorder (ADHD) have shown reduced functional connectivity between the anterior and posterior aspects. This finding was originally demonstrated in adults with ADHD, then in youth with ADHD, and has been tentatively linked to ultra low frequency oscillations within the DMN. The current study evaluates the specificity of DMN abnormalities to neuronal oscillations in the ultra low frequency range, and examines the regional specificity of these DMN aberrations in medicated and unmedicated adults with, and those without ADHD. An individually matched sample of adults with and without ADHD completed 6-minute sessions of resting-state magnetoencephalography (MEG). Participants with ADHD were known responders to stimulant medications and completed two sessions (predrug/postdrug). MEG data were coregistered to the participant's MRI, corrected for head motion, fitted to a regional-level source model, and subjected to spectral analyses to extract neuronal population activity in regions of the DMN. The unmedicated adults with ADHD exhibited broadband deficits in medial prefrontal cortices (MPFC), but not other DMN regions compared to adults without ADHD. Unmedicated patients also showed abnormal cross-frequency coupling in the gamma range between the MPFC and posterior cingulate areas, and disturbed balance within the DMN as activity in posterior regions was stronger than frontal regions at beta and lower frequencies, which dissipated at higher γ-frequencies. Administration of pharmacotherapy significantly increased prefrontal alpha activity (8-14 Hz) in adults with ADHD, and decreased the cross-frequency gamma coupling. These results indicate that neurophysiological aberrations in the DMN of patients with ADHD are not limited to ultra slow oscillations, and that they may be primarily attributable to abnormal broadband activity in the MPFC. Hum Brain Mapp, 2013.

Original languageEnglish (US)
Pages (from-to)566-574
Number of pages9
JournalHuman Brain Mapping
Volume34
Issue number3
DOIs
StatePublished - Mar 1 2013

Fingerprint

Attention Deficit Disorder with Hyperactivity
Prefrontal Cortex
Magnetoencephalography
Gyrus Cinguli
Head
Drug Therapy
Brain

Keywords

  • ADD
  • Attention
  • Delta
  • Gamma
  • MEG
  • Magnetoencephalography
  • Stimulant
  • Theta

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Broadband neurophysiological abnormalities in the medial prefrontal region of the default-mode network in adults with ADHD. / Wilson, Tony W; Franzen, John D.; Heinrichs-Graham, Elizabeth C; White, Matthew L; Knott, Nichole L.; Wetzel, Martin W.

In: Human Brain Mapping, Vol. 34, No. 3, 01.03.2013, p. 566-574.

Research output: Contribution to journalArticle

@article{3674249f84e546ebbaccfe0e3523b589,
title = "Broadband neurophysiological abnormalities in the medial prefrontal region of the default-mode network in adults with ADHD",
abstract = "Previous investigations of the default-mode network (DMN) in persons with attention-deficit/hyperactivity disorder (ADHD) have shown reduced functional connectivity between the anterior and posterior aspects. This finding was originally demonstrated in adults with ADHD, then in youth with ADHD, and has been tentatively linked to ultra low frequency oscillations within the DMN. The current study evaluates the specificity of DMN abnormalities to neuronal oscillations in the ultra low frequency range, and examines the regional specificity of these DMN aberrations in medicated and unmedicated adults with, and those without ADHD. An individually matched sample of adults with and without ADHD completed 6-minute sessions of resting-state magnetoencephalography (MEG). Participants with ADHD were known responders to stimulant medications and completed two sessions (predrug/postdrug). MEG data were coregistered to the participant's MRI, corrected for head motion, fitted to a regional-level source model, and subjected to spectral analyses to extract neuronal population activity in regions of the DMN. The unmedicated adults with ADHD exhibited broadband deficits in medial prefrontal cortices (MPFC), but not other DMN regions compared to adults without ADHD. Unmedicated patients also showed abnormal cross-frequency coupling in the gamma range between the MPFC and posterior cingulate areas, and disturbed balance within the DMN as activity in posterior regions was stronger than frontal regions at beta and lower frequencies, which dissipated at higher γ-frequencies. Administration of pharmacotherapy significantly increased prefrontal alpha activity (8-14 Hz) in adults with ADHD, and decreased the cross-frequency gamma coupling. These results indicate that neurophysiological aberrations in the DMN of patients with ADHD are not limited to ultra slow oscillations, and that they may be primarily attributable to abnormal broadband activity in the MPFC. Hum Brain Mapp, 2013.",
keywords = "ADD, Attention, Delta, Gamma, MEG, Magnetoencephalography, Stimulant, Theta",
author = "Wilson, {Tony W} and Franzen, {John D.} and Heinrichs-Graham, {Elizabeth C} and White, {Matthew L} and Knott, {Nichole L.} and Wetzel, {Martin W.}",
year = "2013",
month = "3",
day = "1",
doi = "10.1002/hbm.21459",
language = "English (US)",
volume = "34",
pages = "566--574",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "3",

}

TY - JOUR

T1 - Broadband neurophysiological abnormalities in the medial prefrontal region of the default-mode network in adults with ADHD

AU - Wilson, Tony W

AU - Franzen, John D.

AU - Heinrichs-Graham, Elizabeth C

AU - White, Matthew L

AU - Knott, Nichole L.

AU - Wetzel, Martin W.

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Previous investigations of the default-mode network (DMN) in persons with attention-deficit/hyperactivity disorder (ADHD) have shown reduced functional connectivity between the anterior and posterior aspects. This finding was originally demonstrated in adults with ADHD, then in youth with ADHD, and has been tentatively linked to ultra low frequency oscillations within the DMN. The current study evaluates the specificity of DMN abnormalities to neuronal oscillations in the ultra low frequency range, and examines the regional specificity of these DMN aberrations in medicated and unmedicated adults with, and those without ADHD. An individually matched sample of adults with and without ADHD completed 6-minute sessions of resting-state magnetoencephalography (MEG). Participants with ADHD were known responders to stimulant medications and completed two sessions (predrug/postdrug). MEG data were coregistered to the participant's MRI, corrected for head motion, fitted to a regional-level source model, and subjected to spectral analyses to extract neuronal population activity in regions of the DMN. The unmedicated adults with ADHD exhibited broadband deficits in medial prefrontal cortices (MPFC), but not other DMN regions compared to adults without ADHD. Unmedicated patients also showed abnormal cross-frequency coupling in the gamma range between the MPFC and posterior cingulate areas, and disturbed balance within the DMN as activity in posterior regions was stronger than frontal regions at beta and lower frequencies, which dissipated at higher γ-frequencies. Administration of pharmacotherapy significantly increased prefrontal alpha activity (8-14 Hz) in adults with ADHD, and decreased the cross-frequency gamma coupling. These results indicate that neurophysiological aberrations in the DMN of patients with ADHD are not limited to ultra slow oscillations, and that they may be primarily attributable to abnormal broadband activity in the MPFC. Hum Brain Mapp, 2013.

AB - Previous investigations of the default-mode network (DMN) in persons with attention-deficit/hyperactivity disorder (ADHD) have shown reduced functional connectivity between the anterior and posterior aspects. This finding was originally demonstrated in adults with ADHD, then in youth with ADHD, and has been tentatively linked to ultra low frequency oscillations within the DMN. The current study evaluates the specificity of DMN abnormalities to neuronal oscillations in the ultra low frequency range, and examines the regional specificity of these DMN aberrations in medicated and unmedicated adults with, and those without ADHD. An individually matched sample of adults with and without ADHD completed 6-minute sessions of resting-state magnetoencephalography (MEG). Participants with ADHD were known responders to stimulant medications and completed two sessions (predrug/postdrug). MEG data were coregistered to the participant's MRI, corrected for head motion, fitted to a regional-level source model, and subjected to spectral analyses to extract neuronal population activity in regions of the DMN. The unmedicated adults with ADHD exhibited broadband deficits in medial prefrontal cortices (MPFC), but not other DMN regions compared to adults without ADHD. Unmedicated patients also showed abnormal cross-frequency coupling in the gamma range between the MPFC and posterior cingulate areas, and disturbed balance within the DMN as activity in posterior regions was stronger than frontal regions at beta and lower frequencies, which dissipated at higher γ-frequencies. Administration of pharmacotherapy significantly increased prefrontal alpha activity (8-14 Hz) in adults with ADHD, and decreased the cross-frequency gamma coupling. These results indicate that neurophysiological aberrations in the DMN of patients with ADHD are not limited to ultra slow oscillations, and that they may be primarily attributable to abnormal broadband activity in the MPFC. Hum Brain Mapp, 2013.

KW - ADD

KW - Attention

KW - Delta

KW - Gamma

KW - MEG

KW - Magnetoencephalography

KW - Stimulant

KW - Theta

UR - http://www.scopus.com/inward/record.url?scp=84873427631&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84873427631&partnerID=8YFLogxK

U2 - 10.1002/hbm.21459

DO - 10.1002/hbm.21459

M3 - Article

VL - 34

SP - 566

EP - 574

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 3

ER -