Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells

Mengqing Xiang, Lijuan Zhou, Y. W. Peng, Roger L. Eddy, Thomas B. Shows, Jeremy Nathans

Research output: Contribution to journalArticle

175 Citations (Scopus)

Abstract

A search for POU domain transcription factors in human retina cDNA has led to the identification of Brn-3b, a class IV POU domain protein. Immunohistochemical experiments show that chicken, mouse, rabbit, monkey, and human retinas contain Brn-3b exclusively within a subpopulation of ganglion cells. In the adult mouse brain, Brn-3b is found only within cells in the deep layers of the superior colliculus, in the dorsal periaquaductal gray, and in a small cluster of cells in the brain stem near the area postrema. During the immediate postnatal period, cells containing Brn-3b are distributed in a number of regions within the brain stem and cerebellum. These data suggest that Brn-3b plays a role in determining and/or maintaining the identities of a small number of neurons, including a subset of visual system neurons.

Original languageEnglish (US)
Pages (from-to)689-701
Number of pages13
JournalNeuron
Volume11
Issue number4
DOIs
StatePublished - Oct 1993

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Retinal Ganglion Cells
POU Domain Factors
Genes
Brain Stem
Retina
Area Postrema
Neurons
Superior Colliculi
Ganglia
Cerebellum
Haplorhini
Chickens
Complementary DNA
Rabbits
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Xiang, M., Zhou, L., Peng, Y. W., Eddy, R. L., Shows, T. B., & Nathans, J. (1993). Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. Neuron, 11(4), 689-701. https://doi.org/10.1016/0896-6273(93)90079-7

Brn-3b : a POU domain gene expressed in a subset of retinal ganglion cells. / Xiang, Mengqing; Zhou, Lijuan; Peng, Y. W.; Eddy, Roger L.; Shows, Thomas B.; Nathans, Jeremy.

In: Neuron, Vol. 11, No. 4, 10.1993, p. 689-701.

Research output: Contribution to journalArticle

Xiang, M, Zhou, L, Peng, YW, Eddy, RL, Shows, TB & Nathans, J 1993, 'Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells', Neuron, vol. 11, no. 4, pp. 689-701. https://doi.org/10.1016/0896-6273(93)90079-7
Xiang M, Zhou L, Peng YW, Eddy RL, Shows TB, Nathans J. Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells. Neuron. 1993 Oct;11(4):689-701. https://doi.org/10.1016/0896-6273(93)90079-7
Xiang, Mengqing ; Zhou, Lijuan ; Peng, Y. W. ; Eddy, Roger L. ; Shows, Thomas B. ; Nathans, Jeremy. / Brn-3b : a POU domain gene expressed in a subset of retinal ganglion cells. In: Neuron. 1993 ; Vol. 11, No. 4. pp. 689-701.
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