Breast carcinoma in bronchoalveolar lavage. A cytologic and immunocytochemical study

Stanley J Radio, S. I. Rennard, A. Kessinger, W. P. Vaughan, James Linder

Research output: Contribution to journalArticle

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Abstract

To evaluate the effectiveness of bronchoalveolar lavage in detecting pulmonary metastases of breast cancer, we examined lavage fluid from 20 patients with routine cytologic preparations and immunoperoxidase stains with monoclonal antibody B72.3. Bronchoscopy was performed for infection surveillance prior to autologous bone marrow transplantation (nine patients), or to assess abnormal chest roentgenogram (11 patients). Metastatic adenocarcinoma was identified on Papanicolaou-stained-membrane filters in seven patients (35%), corroborated by transbronchial biopsy in four patients. No patients with chest roentgenogram suggestive of metastatic cancer or transbronchial biopsy positive for metastatic cancer had a negative lavage. Monoclonal antibody B72.3 uniformly marked malignant cell aggregates and many single cells that were inapparent in routinely stained material. Because bronchoalveolar lavage may detect metastatic adenocarcinoma with sensitivity comparable to transbronchial biopsy but with less morbidity, it is useful in the evaluation of pulmonary infiltrates in patients with primary breast carcinoma. Staining with monoclonal antibody B72.3 can be readily performed on lavage specimens and may serve as an adjunct in diagnosing malignancy.

Original languageEnglish (US)
Pages (from-to)333-336
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume113
Issue number4
StatePublished - Jan 1 1989

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Bronchoalveolar Lavage
Breast Neoplasms
Therapeutic Irrigation
Monoclonal Antibodies
Biopsy
Adenocarcinoma
Thorax
Neoplasms
Lung
Autologous Transplantation
Bronchoscopy
Bone Marrow Transplantation
Coloring Agents
Staining and Labeling
Neoplasm Metastasis
Morbidity
Membranes
Infection
B72.3 antibody

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Breast carcinoma in bronchoalveolar lavage. A cytologic and immunocytochemical study. / Radio, Stanley J; Rennard, S. I.; Kessinger, A.; Vaughan, W. P.; Linder, James.

In: Archives of Pathology and Laboratory Medicine, Vol. 113, No. 4, 01.01.1989, p. 333-336.

Research output: Contribution to journalArticle

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