Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome

Robert Tanner Hagelstrom, James Ford, Gwendolyn M. Reiser, Marilu Nelson, Diane L. Pickering, Pamela A. Althof, Warren G. Sanger, Peter F. Coccia

Research output: Contribution to journalArticle

1 Scopus citations


Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2); however, no such association has been reported in patients with Cowden syndrome (involving the phosphatase and tensin homolog [PTEN] gene). We describe a patient with Cowden syndrome who was initially diagnosed with B-cell lymphoblastic lymphoma at the age of 7 years, then MBC at the age of 31 years, and never received radiation therapy.

Original languageEnglish (US)
Pages (from-to)544-546
Number of pages3
JournalPediatric Blood and Cancer
Issue number3
Publication statusPublished - Mar 1 2016



  • B-cell lymphoblastic lymphoma
  • Cowden syndrome
  • Male breast cancer
  • PTEN

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Hagelstrom, R. T., Ford, J., Reiser, G. M., Nelson, M., Pickering, D. L., Althof, P. A., ... Coccia, P. F. (2016). Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome. Pediatric Blood and Cancer, 63(3), 544-546.