Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome

Robert Tanner Hagelstrom, James Ford, Gwendolyn M. Reiser, Marilu Nelson, Diane L. Pickering, Pamela A. Althof, Warren G. Sanger, Peter F. Coccia

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Male breast cancer (MBC) is unusual, especially in young adults. Most cases of MBC as a secondary malignancy relate to the previous treatment with ionizing radiation. MBC can be associated with mutations in hereditary cancer predisposition syndrome genes (i.e., BRCA2); however, no such association has been reported in patients with Cowden syndrome (involving the phosphatase and tensin homolog [PTEN] gene). We describe a patient with Cowden syndrome who was initially diagnosed with B-cell lymphoblastic lymphoma at the age of 7 years, then MBC at the age of 31 years, and never received radiation therapy.

Original languageEnglish (US)
Pages (from-to)544-546
Number of pages3
JournalPediatric Blood and Cancer
Volume63
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Multiple Hamartoma Syndrome
Male Breast Neoplasms
Non-Hodgkin's Lymphoma
Breast Neoplasms
Hereditary Neoplastic Syndromes
BRCA2 Gene
B-Cell Lymphoma
Ionizing Radiation
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Phosphoric Monoester Hydrolases
Young Adult
Radiotherapy
Mutation
Genes
Neoplasms

Keywords

  • B-cell lymphoblastic lymphoma
  • Cowden syndrome
  • Male breast cancer
  • PTEN

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Hagelstrom, R. T., Ford, J., Reiser, G. M., Nelson, M., Pickering, D. L., Althof, P. A., ... Coccia, P. F. (2016). Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome. Pediatric Blood and Cancer, 63(3), 544-546. https://doi.org/10.1002/pbc.25796

Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome. / Hagelstrom, Robert Tanner; Ford, James; Reiser, Gwendolyn M.; Nelson, Marilu; Pickering, Diane L.; Althof, Pamela A.; Sanger, Warren G.; Coccia, Peter F.

In: Pediatric Blood and Cancer, Vol. 63, No. 3, 01.03.2016, p. 544-546.

Research output: Contribution to journalArticle

Hagelstrom, RT, Ford, J, Reiser, GM, Nelson, M, Pickering, DL, Althof, PA, Sanger, WG & Coccia, PF 2016, 'Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome', Pediatric Blood and Cancer, vol. 63, no. 3, pp. 544-546. https://doi.org/10.1002/pbc.25796
Hagelstrom RT, Ford J, Reiser GM, Nelson M, Pickering DL, Althof PA et al. Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome. Pediatric Blood and Cancer. 2016 Mar 1;63(3):544-546. https://doi.org/10.1002/pbc.25796
Hagelstrom, Robert Tanner ; Ford, James ; Reiser, Gwendolyn M. ; Nelson, Marilu ; Pickering, Diane L. ; Althof, Pamela A. ; Sanger, Warren G. ; Coccia, Peter F. / Breast Cancer and Non-Hodgkin Lymphoma in a Young Male with Cowden Syndrome. In: Pediatric Blood and Cancer. 2016 ; Vol. 63, No. 3. pp. 544-546.
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