Breakthroughs in the search for dyslexia candidate genes

Lauren M. McGrath, Shelley D Smith, Bruce F. Pennington

Research output: Contribution to journalReview article

60 Citations (Scopus)

Abstract

Four genes have recently been proposed as candidates for dyslexia: dyslexia susceptibility 1 candidate 1 (DYX1C1), roundabout Drosophila homolog 1 (ROBO1), doublecortin domain-containing protein 2 (DCDC2) and KIAA0319. Each gene is implicated in global brain-development processes such as neural migration and axonal guidance, with the exception of DYX1C1, the function of which is still unknown. The most immediate clinical prospect of the discovery of these genes is the possibility of early identification of dyslexia via genetic screening. However, research efforts have yet to identify a functional mutation in any of these genes. When causal variants are identified, they will need to be considered within a multifactorial framework, which is likely to involve gene-gene and gene-environment interactions, to make accurate predictions of diagnostic status.

Original languageEnglish (US)
Pages (from-to)333-341
Number of pages9
JournalTrends in Molecular Medicine
Volume12
Issue number7
DOIs
StatePublished - Jul 1 2006

Fingerprint

Dyslexia
Genes
Gene-Environment Interaction
Genetic Testing
Genetic Association Studies
Drosophila
Mutation
Brain
Research

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

Cite this

Breakthroughs in the search for dyslexia candidate genes. / McGrath, Lauren M.; Smith, Shelley D; Pennington, Bruce F.

In: Trends in Molecular Medicine, Vol. 12, No. 7, 01.07.2006, p. 333-341.

Research output: Contribution to journalReview article

McGrath, Lauren M. ; Smith, Shelley D ; Pennington, Bruce F. / Breakthroughs in the search for dyslexia candidate genes. In: Trends in Molecular Medicine. 2006 ; Vol. 12, No. 7. pp. 333-341.
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