Breaking the species barrier

Use of SCID mouse-human chimeras for the study of human infectious diseases

Paul H Davis, Samuel L. Stanley

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Mouse-human chimeras have become a novel way to model the interactions between microbial pathogens and human cells, tissues or organs. Diseases studied with human xenografts in severe combined immunodeficient (SCID) mice include Pseudomonas aeruginosa infection in cystic fibrosis, group A streptococci and impetigo, bacillary and amoebic dysentery, and AIDS. In many cases, disease in the human xenograft appears to accurately reproduce the disease in humans, providing a powerful model for identifying virulence factors, host responses to infection and the effects of specific interventions on disease. In this review, we summarize recent studies that have used mouse-human chimeras to understand the pathophysiology of specific bacterial and protozoan infections.

Original languageEnglish (US)
Pages (from-to)849-860
Number of pages12
JournalCellular Microbiology
Volume5
Issue number12
DOIs
StatePublished - Dec 1 2003

Fingerprint

SCID Mice
Communicable Diseases
Heterografts
Virulence Factors
Pathogens
Microbial Interactions
Protozoan Infections
Impetigo
Amoebic Dysentery
Bacillary Dysentery
Pseudomonas Infections
Cells
Tissue
Streptococcus
Bacterial Infections
Cystic Fibrosis
Pseudomonas aeruginosa
Acquired Immunodeficiency Syndrome
Infection

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Virology

Cite this

Breaking the species barrier : Use of SCID mouse-human chimeras for the study of human infectious diseases. / Davis, Paul H; Stanley, Samuel L.

In: Cellular Microbiology, Vol. 5, No. 12, 01.12.2003, p. 849-860.

Research output: Contribution to journalReview article

@article{5f4794e06c024851a01ccccb2394d117,
title = "Breaking the species barrier: Use of SCID mouse-human chimeras for the study of human infectious diseases",
abstract = "Mouse-human chimeras have become a novel way to model the interactions between microbial pathogens and human cells, tissues or organs. Diseases studied with human xenografts in severe combined immunodeficient (SCID) mice include Pseudomonas aeruginosa infection in cystic fibrosis, group A streptococci and impetigo, bacillary and amoebic dysentery, and AIDS. In many cases, disease in the human xenograft appears to accurately reproduce the disease in humans, providing a powerful model for identifying virulence factors, host responses to infection and the effects of specific interventions on disease. In this review, we summarize recent studies that have used mouse-human chimeras to understand the pathophysiology of specific bacterial and protozoan infections.",
author = "Davis, {Paul H} and Stanley, {Samuel L.}",
year = "2003",
month = "12",
day = "1",
doi = "10.1046/j.1462-5822.2003.00321.x",
language = "English (US)",
volume = "5",
pages = "849--860",
journal = "Cellular Microbiology",
issn = "1462-5814",
publisher = "Wiley-Blackwell",
number = "12",

}

TY - JOUR

T1 - Breaking the species barrier

T2 - Use of SCID mouse-human chimeras for the study of human infectious diseases

AU - Davis, Paul H

AU - Stanley, Samuel L.

PY - 2003/12/1

Y1 - 2003/12/1

N2 - Mouse-human chimeras have become a novel way to model the interactions between microbial pathogens and human cells, tissues or organs. Diseases studied with human xenografts in severe combined immunodeficient (SCID) mice include Pseudomonas aeruginosa infection in cystic fibrosis, group A streptococci and impetigo, bacillary and amoebic dysentery, and AIDS. In many cases, disease in the human xenograft appears to accurately reproduce the disease in humans, providing a powerful model for identifying virulence factors, host responses to infection and the effects of specific interventions on disease. In this review, we summarize recent studies that have used mouse-human chimeras to understand the pathophysiology of specific bacterial and protozoan infections.

AB - Mouse-human chimeras have become a novel way to model the interactions between microbial pathogens and human cells, tissues or organs. Diseases studied with human xenografts in severe combined immunodeficient (SCID) mice include Pseudomonas aeruginosa infection in cystic fibrosis, group A streptococci and impetigo, bacillary and amoebic dysentery, and AIDS. In many cases, disease in the human xenograft appears to accurately reproduce the disease in humans, providing a powerful model for identifying virulence factors, host responses to infection and the effects of specific interventions on disease. In this review, we summarize recent studies that have used mouse-human chimeras to understand the pathophysiology of specific bacterial and protozoan infections.

UR - http://www.scopus.com/inward/record.url?scp=0345602112&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0345602112&partnerID=8YFLogxK

U2 - 10.1046/j.1462-5822.2003.00321.x

DO - 10.1046/j.1462-5822.2003.00321.x

M3 - Review article

VL - 5

SP - 849

EP - 860

JO - Cellular Microbiology

JF - Cellular Microbiology

SN - 1462-5814

IS - 12

ER -