BRCT domains: A little more than kin, and less than kind

Dietlind L. Gerloff, Nicholas T. Woods, April A. Farago, Alvaro N.A. Monteiro

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

BRCT domains are versatile protein modular domains found as single units or as multiple copies in more than 20 different proteins in the human genome. Interestingly, most BRCT-containing proteins function in the same biological process, the DNA damage response network, but show specificity in their molecular interactions. BRCT domains have been found to bind a wide array of ligands from proteins, phosphorylated linear motifs, and DNA. Here we discuss the biology of BRCT domains and how a domain-centric analysis can aid in the understanding of signal transduction events in the DNA damage response network.

Original languageEnglish (US)
Pages (from-to)2711-2716
Number of pages6
JournalFEBS Letters
Volume586
Issue number17
DOIs
StatePublished - Aug 14 2012

Fingerprint

DNA Damage
Biological Phenomena
Protein Array Analysis
Nucleotide Motifs
Human Genome
Signal Transduction
DNA
Proteins
Ligands
Signal transduction
Molecular interactions
Genes
Protein Domains

Keywords

  • BRCT domain
  • DNA damage response
  • Phosphopeptide binding
  • Protein domain

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

BRCT domains : A little more than kin, and less than kind. / Gerloff, Dietlind L.; Woods, Nicholas T.; Farago, April A.; Monteiro, Alvaro N.A.

In: FEBS Letters, Vol. 586, No. 17, 14.08.2012, p. 2711-2716.

Research output: Contribution to journalReview article

Gerloff, DL, Woods, NT, Farago, AA & Monteiro, ANA 2012, 'BRCT domains: A little more than kin, and less than kind', FEBS Letters, vol. 586, no. 17, pp. 2711-2716. https://doi.org/10.1016/j.febslet.2012.05.005
Gerloff, Dietlind L. ; Woods, Nicholas T. ; Farago, April A. ; Monteiro, Alvaro N.A. / BRCT domains : A little more than kin, and less than kind. In: FEBS Letters. 2012 ; Vol. 586, No. 17. pp. 2711-2716.
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