BRCT domains: A little more than kin, and less than kind

Dietlind L. Gerloff, Nicholas T. Woods, April A. Farago, Alvaro N.A. Monteiro

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

BRCT domains are versatile protein modular domains found as single units or as multiple copies in more than 20 different proteins in the human genome. Interestingly, most BRCT-containing proteins function in the same biological process, the DNA damage response network, but show specificity in their molecular interactions. BRCT domains have been found to bind a wide array of ligands from proteins, phosphorylated linear motifs, and DNA. Here we discuss the biology of BRCT domains and how a domain-centric analysis can aid in the understanding of signal transduction events in the DNA damage response network.

Original languageEnglish (US)
Pages (from-to)2711-2716
Number of pages6
JournalFEBS Letters
Volume586
Issue number17
DOIs
StatePublished - Aug 14 2012

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Keywords

  • BRCT domain
  • DNA damage response
  • Phosphopeptide binding
  • Protein domain

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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