Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma

Ultrastructural features and differential diagnosis

Matthew D. Cykowski, John Hicks, David I. Sandberg, Adriana Olar, Julia Ann Bridge, Patricia T. Greipp, Patricia Navarro, Steven Kolodziej, Meenakshi B. Bhattacharjee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report a case of alveolar soft part sarcoma (ASPS) presenting as an isolated frontal lobe metastasis. The tumor demonstrated little or no immunoreactivity for a broad panel of antibodies yet strong, diffuse immunoreactivity with CD68. On electron microscopy, the characteristic rectangular to rhomboid crystalline inclusions of ASPS were not present. Electron-dense granules resembling peroxisomes were present, sometimes in association with elongated granular structures having a periodic, lattice-like arrangement. Metastatic ASPS was confirmed by demonstration of an ASPSCR1-TFE3 fusion and imaging studies that excluded metastatic Xp11.2 translocation renal cell carcinoma. The primary site was subsequently identified in the lower extremity.

Original languageEnglish (US)
Pages (from-to)69-77
Number of pages9
JournalUltrastructural Pathology
Volume39
Issue number1
DOIs
StatePublished - Feb 1 2015

Fingerprint

Alveolar Soft Part Sarcoma
Differential Diagnosis
Neoplasm Metastasis
Brain
Peroxisomes
Frontal Lobe
Renal Cell Carcinoma
Lower Extremity
Electron Microscopy
Electrons
Antibodies
Neoplasms

Keywords

  • Alveolar soft part sarcoma
  • Brain metastasis
  • CD68

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology

Cite this

Cykowski, M. D., Hicks, J., Sandberg, D. I., Olar, A., Bridge, J. A., Greipp, P. T., ... Bhattacharjee, M. B. (2015). Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma: Ultrastructural features and differential diagnosis. Ultrastructural Pathology, 39(1), 69-77. https://doi.org/10.3109/01913123.2014.950778

Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma : Ultrastructural features and differential diagnosis. / Cykowski, Matthew D.; Hicks, John; Sandberg, David I.; Olar, Adriana; Bridge, Julia Ann; Greipp, Patricia T.; Navarro, Patricia; Kolodziej, Steven; Bhattacharjee, Meenakshi B.

In: Ultrastructural Pathology, Vol. 39, No. 1, 01.02.2015, p. 69-77.

Research output: Contribution to journalArticle

Cykowski, MD, Hicks, J, Sandberg, DI, Olar, A, Bridge, JA, Greipp, PT, Navarro, P, Kolodziej, S & Bhattacharjee, MB 2015, 'Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma: Ultrastructural features and differential diagnosis', Ultrastructural Pathology, vol. 39, no. 1, pp. 69-77. https://doi.org/10.3109/01913123.2014.950778
Cykowski, Matthew D. ; Hicks, John ; Sandberg, David I. ; Olar, Adriana ; Bridge, Julia Ann ; Greipp, Patricia T. ; Navarro, Patricia ; Kolodziej, Steven ; Bhattacharjee, Meenakshi B. / Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma : Ultrastructural features and differential diagnosis. In: Ultrastructural Pathology. 2015 ; Vol. 39, No. 1. pp. 69-77.
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