Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma: Ultrastructural features and differential diagnosis

Matthew D. Cykowski, John Hicks, David I. Sandberg, Adriana Olar, Julia A. Bridge, Patricia T. Greipp, Patricia Navarro, Steven Kolodziej, Meenakshi B. Bhattacharjee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report a case of alveolar soft part sarcoma (ASPS) presenting as an isolated frontal lobe metastasis. The tumor demonstrated little or no immunoreactivity for a broad panel of antibodies yet strong, diffuse immunoreactivity with CD68. On electron microscopy, the characteristic rectangular to rhomboid crystalline inclusions of ASPS were not present. Electron-dense granules resembling peroxisomes were present, sometimes in association with elongated granular structures having a periodic, lattice-like arrangement. Metastatic ASPS was confirmed by demonstration of an ASPSCR1-TFE3 fusion and imaging studies that excluded metastatic Xp11.2 translocation renal cell carcinoma. The primary site was subsequently identified in the lower extremity.

Original languageEnglish (US)
Pages (from-to)69-77
Number of pages9
JournalUltrastructural Pathology
Volume39
Issue number1
DOIs
StatePublished - Feb 1 2015

Fingerprint

Alveolar Soft Part Sarcoma
Differential Diagnosis
Neoplasm Metastasis
Brain
Peroxisomes
Frontal Lobe
Renal Cell Carcinoma
Lower Extremity
Electron Microscopy
Electrons
Antibodies
Neoplasms

Keywords

  • Alveolar soft part sarcoma
  • Brain metastasis
  • CD68

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Structural Biology

Cite this

Cykowski, M. D., Hicks, J., Sandberg, D. I., Olar, A., Bridge, J. A., Greipp, P. T., ... Bhattacharjee, M. B. (2015). Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma: Ultrastructural features and differential diagnosis. Ultrastructural Pathology, 39(1), 69-77. https://doi.org/10.3109/01913123.2014.950778

Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma : Ultrastructural features and differential diagnosis. / Cykowski, Matthew D.; Hicks, John; Sandberg, David I.; Olar, Adriana; Bridge, Julia A.; Greipp, Patricia T.; Navarro, Patricia; Kolodziej, Steven; Bhattacharjee, Meenakshi B.

In: Ultrastructural Pathology, Vol. 39, No. 1, 01.02.2015, p. 69-77.

Research output: Contribution to journalArticle

Cykowski, MD, Hicks, J, Sandberg, DI, Olar, A, Bridge, JA, Greipp, PT, Navarro, P, Kolodziej, S & Bhattacharjee, MB 2015, 'Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma: Ultrastructural features and differential diagnosis', Ultrastructural Pathology, vol. 39, no. 1, pp. 69-77. https://doi.org/10.3109/01913123.2014.950778
Cykowski, Matthew D. ; Hicks, John ; Sandberg, David I. ; Olar, Adriana ; Bridge, Julia A. ; Greipp, Patricia T. ; Navarro, Patricia ; Kolodziej, Steven ; Bhattacharjee, Meenakshi B. / Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma : Ultrastructural features and differential diagnosis. In: Ultrastructural Pathology. 2015 ; Vol. 39, No. 1. pp. 69-77.
@article{f5d31f5657024583acc7093c8f4cef40,
title = "Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma: Ultrastructural features and differential diagnosis",
abstract = "We report a case of alveolar soft part sarcoma (ASPS) presenting as an isolated frontal lobe metastasis. The tumor demonstrated little or no immunoreactivity for a broad panel of antibodies yet strong, diffuse immunoreactivity with CD68. On electron microscopy, the characteristic rectangular to rhomboid crystalline inclusions of ASPS were not present. Electron-dense granules resembling peroxisomes were present, sometimes in association with elongated granular structures having a periodic, lattice-like arrangement. Metastatic ASPS was confirmed by demonstration of an ASPSCR1-TFE3 fusion and imaging studies that excluded metastatic Xp11.2 translocation renal cell carcinoma. The primary site was subsequently identified in the lower extremity.",
keywords = "Alveolar soft part sarcoma, Brain metastasis, CD68",
author = "Cykowski, {Matthew D.} and John Hicks and Sandberg, {David I.} and Adriana Olar and Bridge, {Julia A.} and Greipp, {Patricia T.} and Patricia Navarro and Steven Kolodziej and Bhattacharjee, {Meenakshi B.}",
year = "2015",
month = "2",
day = "1",
doi = "10.3109/01913123.2014.950778",
language = "English (US)",
volume = "39",
pages = "69--77",
journal = "Ultrastructural Pathology",
issn = "0191-3123",
publisher = "Informa Healthcare",
number = "1",

}

TY - JOUR

T1 - Brain metastasis of crystal-deficient, CD68-positive alveolar soft part sarcoma

T2 - Ultrastructural features and differential diagnosis

AU - Cykowski, Matthew D.

AU - Hicks, John

AU - Sandberg, David I.

AU - Olar, Adriana

AU - Bridge, Julia A.

AU - Greipp, Patricia T.

AU - Navarro, Patricia

AU - Kolodziej, Steven

AU - Bhattacharjee, Meenakshi B.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - We report a case of alveolar soft part sarcoma (ASPS) presenting as an isolated frontal lobe metastasis. The tumor demonstrated little or no immunoreactivity for a broad panel of antibodies yet strong, diffuse immunoreactivity with CD68. On electron microscopy, the characteristic rectangular to rhomboid crystalline inclusions of ASPS were not present. Electron-dense granules resembling peroxisomes were present, sometimes in association with elongated granular structures having a periodic, lattice-like arrangement. Metastatic ASPS was confirmed by demonstration of an ASPSCR1-TFE3 fusion and imaging studies that excluded metastatic Xp11.2 translocation renal cell carcinoma. The primary site was subsequently identified in the lower extremity.

AB - We report a case of alveolar soft part sarcoma (ASPS) presenting as an isolated frontal lobe metastasis. The tumor demonstrated little or no immunoreactivity for a broad panel of antibodies yet strong, diffuse immunoreactivity with CD68. On electron microscopy, the characteristic rectangular to rhomboid crystalline inclusions of ASPS were not present. Electron-dense granules resembling peroxisomes were present, sometimes in association with elongated granular structures having a periodic, lattice-like arrangement. Metastatic ASPS was confirmed by demonstration of an ASPSCR1-TFE3 fusion and imaging studies that excluded metastatic Xp11.2 translocation renal cell carcinoma. The primary site was subsequently identified in the lower extremity.

KW - Alveolar soft part sarcoma

KW - Brain metastasis

KW - CD68

UR - http://www.scopus.com/inward/record.url?scp=84921735669&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84921735669&partnerID=8YFLogxK

U2 - 10.3109/01913123.2014.950778

DO - 10.3109/01913123.2014.950778

M3 - Article

C2 - 25268941

AN - SCOPUS:84921735669

VL - 39

SP - 69

EP - 77

JO - Ultrastructural Pathology

JF - Ultrastructural Pathology

SN - 0191-3123

IS - 1

ER -