Brain Abscesses

Etiologic Categorization with in Vivo Proton MR Spectroscopy

Monika Garg, Rakesh K. Gupta, Mazhar Husain, Sanjeev Chawla, Jayant Chawla, Rajesh Kumar, Balasrinivasa R Sajja, Mithlesh K. Misra, Kashi N. Prasad

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To compare the metabolite patterns observed at in vivo proton magnetic resonance (MR) spectroscopy of brain abscesses in patients for whom bacteriologic information was obtained from cultures and to categorize the MR spectral patterns with respect to the underlying etiologic agents. MATERIALS AND METHODS: MR imaging and in vivo single-voxel proton MR spectroscopic data obtained from 75 patients with brain abscesses were retrospectively analyzed. Ex vivo spectroscopic experiments with the pus from 45 of these patients also were performed, and the data were further categorized on the basis of bacteriologic information. Quantification of various metabolites and metabolite ratios and statistical analyses of lactate and lactate/amino acid (AA) ratio levels were performed by using one-way analysis of variance. RESULTS: On the basis of in vivo proton MR spectroscopic and bacteriologic analysis findings, data were classified into three categories: Group 1 data showed resonances of lactate, AAs, and acetate, with or without succinate at proton MR spectroscopy; cultures for this group showed obligate anaerobes or a mixture of obligate and facultative anaerobes. The metabolite patterns in the group 2 and group 3 data were similar to the pattern of the group 1 data, with the exception that acetate and succinate resonances were absent. Culture was positive for either obligate aerobes or facultative anaerobes in group 2 and was sterile in group 3. At analysis of variance, in vivo data showed significant differences in lactate/AA ratios (P = .008), and ex vivo data showed significant differences in lactate levels (P = .001) among the three groups. CONCLUSION: It is possible to differentiate anaerobic from aerobic or sterile brain abscesses on the basis of metabolite patterns observed at in vivo proton MR spectroscopy. This information may be useful in facilitating prompt and appropriate treatment of patients with these abscesses.

Original languageEnglish (US)
Pages (from-to)519-527
Number of pages9
JournalRadiology
Volume230
Issue number2
DOIs
StatePublished - Feb 1 2004

Fingerprint

Brain Abscess
Lactic Acid
Magnetic Resonance Spectroscopy
Succinic Acid
Protons
Analysis of Variance
Acetates
Amino Acids
Suppuration
Abscess
Magnetic Resonance Imaging
Proton Magnetic Resonance Spectroscopy

Keywords

  • Brain, MR
  • Brain, abscess
  • Brain, infection
  • Magnetic resonance (MR), spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Garg, M., Gupta, R. K., Husain, M., Chawla, S., Chawla, J., Kumar, R., ... Prasad, K. N. (2004). Brain Abscesses: Etiologic Categorization with in Vivo Proton MR Spectroscopy. Radiology, 230(2), 519-527. https://doi.org/10.1148/radiol.2302021317

Brain Abscesses : Etiologic Categorization with in Vivo Proton MR Spectroscopy. / Garg, Monika; Gupta, Rakesh K.; Husain, Mazhar; Chawla, Sanjeev; Chawla, Jayant; Kumar, Rajesh; Sajja, Balasrinivasa R; Misra, Mithlesh K.; Prasad, Kashi N.

In: Radiology, Vol. 230, No. 2, 01.02.2004, p. 519-527.

Research output: Contribution to journalArticle

Garg, M, Gupta, RK, Husain, M, Chawla, S, Chawla, J, Kumar, R, Sajja, BR, Misra, MK & Prasad, KN 2004, 'Brain Abscesses: Etiologic Categorization with in Vivo Proton MR Spectroscopy', Radiology, vol. 230, no. 2, pp. 519-527. https://doi.org/10.1148/radiol.2302021317
Garg M, Gupta RK, Husain M, Chawla S, Chawla J, Kumar R et al. Brain Abscesses: Etiologic Categorization with in Vivo Proton MR Spectroscopy. Radiology. 2004 Feb 1;230(2):519-527. https://doi.org/10.1148/radiol.2302021317
Garg, Monika ; Gupta, Rakesh K. ; Husain, Mazhar ; Chawla, Sanjeev ; Chawla, Jayant ; Kumar, Rajesh ; Sajja, Balasrinivasa R ; Misra, Mithlesh K. ; Prasad, Kashi N. / Brain Abscesses : Etiologic Categorization with in Vivo Proton MR Spectroscopy. In: Radiology. 2004 ; Vol. 230, No. 2. pp. 519-527.
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abstract = "PURPOSE: To compare the metabolite patterns observed at in vivo proton magnetic resonance (MR) spectroscopy of brain abscesses in patients for whom bacteriologic information was obtained from cultures and to categorize the MR spectral patterns with respect to the underlying etiologic agents. MATERIALS AND METHODS: MR imaging and in vivo single-voxel proton MR spectroscopic data obtained from 75 patients with brain abscesses were retrospectively analyzed. Ex vivo spectroscopic experiments with the pus from 45 of these patients also were performed, and the data were further categorized on the basis of bacteriologic information. Quantification of various metabolites and metabolite ratios and statistical analyses of lactate and lactate/amino acid (AA) ratio levels were performed by using one-way analysis of variance. RESULTS: On the basis of in vivo proton MR spectroscopic and bacteriologic analysis findings, data were classified into three categories: Group 1 data showed resonances of lactate, AAs, and acetate, with or without succinate at proton MR spectroscopy; cultures for this group showed obligate anaerobes or a mixture of obligate and facultative anaerobes. The metabolite patterns in the group 2 and group 3 data were similar to the pattern of the group 1 data, with the exception that acetate and succinate resonances were absent. Culture was positive for either obligate aerobes or facultative anaerobes in group 2 and was sterile in group 3. At analysis of variance, in vivo data showed significant differences in lactate/AA ratios (P = .008), and ex vivo data showed significant differences in lactate levels (P = .001) among the three groups. CONCLUSION: It is possible to differentiate anaerobic from aerobic or sterile brain abscesses on the basis of metabolite patterns observed at in vivo proton MR spectroscopy. This information may be useful in facilitating prompt and appropriate treatment of patients with these abscesses.",
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AU - Chawla, Sanjeev

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AU - Kumar, Rajesh

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N2 - PURPOSE: To compare the metabolite patterns observed at in vivo proton magnetic resonance (MR) spectroscopy of brain abscesses in patients for whom bacteriologic information was obtained from cultures and to categorize the MR spectral patterns with respect to the underlying etiologic agents. MATERIALS AND METHODS: MR imaging and in vivo single-voxel proton MR spectroscopic data obtained from 75 patients with brain abscesses were retrospectively analyzed. Ex vivo spectroscopic experiments with the pus from 45 of these patients also were performed, and the data were further categorized on the basis of bacteriologic information. Quantification of various metabolites and metabolite ratios and statistical analyses of lactate and lactate/amino acid (AA) ratio levels were performed by using one-way analysis of variance. RESULTS: On the basis of in vivo proton MR spectroscopic and bacteriologic analysis findings, data were classified into three categories: Group 1 data showed resonances of lactate, AAs, and acetate, with or without succinate at proton MR spectroscopy; cultures for this group showed obligate anaerobes or a mixture of obligate and facultative anaerobes. The metabolite patterns in the group 2 and group 3 data were similar to the pattern of the group 1 data, with the exception that acetate and succinate resonances were absent. Culture was positive for either obligate aerobes or facultative anaerobes in group 2 and was sterile in group 3. At analysis of variance, in vivo data showed significant differences in lactate/AA ratios (P = .008), and ex vivo data showed significant differences in lactate levels (P = .001) among the three groups. CONCLUSION: It is possible to differentiate anaerobic from aerobic or sterile brain abscesses on the basis of metabolite patterns observed at in vivo proton MR spectroscopy. This information may be useful in facilitating prompt and appropriate treatment of patients with these abscesses.

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