Brachytherapy: A viable alternative in the management of basal meningiomas

P. P. Kumar, A. A. Patil, L. G. Leibrock, W. K. Chu, J. Syh, G. F. McCaul, M. A. Reeves

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Thirteen patients with intracranial meningiomas of the skull base were treated with one or more high-activity iodine-125 seeds. In 11 patients, the seeds were implanted stereotactically under local anesthesia. A minimum dose of 100 to 500 Gy was delivered to the tumor at a dose rate of 5 to 25 cGy/h. Indications for this procedure included recurrence after initial surgery or as the primary modality of treatment in patients who were not candidates for surgery. All 13 patients are alive at a median follow-up of 15 months. Nine of 11 patients (82%) without calcification in their meningiomas achieved complete response. The remaining 4 patients - 2 with calcification and 2 without - achieved partial response. No early or late complications were observed. We conclude from our experience that both recurrent and primary meningiomas of the skull base can be treated effectively with permanent iodine-125 brachytherapy.

Original languageEnglish (US)
Pages (from-to)676-680
Number of pages5
JournalNeurosurgery
Volume29
Issue number5
DOIs
StatePublished - Jan 1 1991

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Keywords

  • High-activity iodine-125 seeds
  • Meningiomas
  • Stereotactic brachytherapy

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Kumar, P. P., Patil, A. A., Leibrock, L. G., Chu, W. K., Syh, J., McCaul, G. F., & Reeves, M. A. (1991). Brachytherapy: A viable alternative in the management of basal meningiomas. Neurosurgery, 29(5), 676-680. https://doi.org/10.1227/00006123-199111000-00006